DNA Nanodevice-Based Drug Delivery Systems

DNA, a natural biological material, has become an ideal choice for biomedical applications, mainly owing to its good biocompatibility, ease of synthesis, modifiability, and especially programmability. In recent years, with the deepening of the understanding of the physical and chemical properties of DNA and the continuous advancement of DNA synthesis and modification technology, the biomedical applications based on DNA materials have been upgraded to version 2.0: through elaborate design and fabrication of smart-responsive DNA nanodevices, they can respond to external or internal physical or chemical stimuli so as to smartly perform certain specific functions. For tumor treatment, this advancement provides a new way to solve the problems of precise targeting, controllable release, and controllable elimination of drugs to a certain extent. Here, we review the progress of related fields over the past decade, and provide prospects for possible future development directions.

Automated summary

DNA, as a natural biological material, is increasingly being utilized for biomedical applications due to its biocompatibility, ease of synthesis, modifiability, and programmability. Advancements in DNA synthesis and modification technology have led to the development of smart-responsive DNA nanodevices that can intelligently respond to external stimuli, providing new solutions for targeted drug delivery and tumor treatment. Looking ahead, there are promising prospects for further advancements in this field.