期刊
BIOMOLECULES
卷 11, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/biom11111604
关键词
hypoxia; cancer; tirapazamine; hyperthermia; carbogen breathing; tumour metabolism
资金
- MRCQQR programme grant [MC_UU_00001/11]
Tumour hypoxia is closely related to patient survival and treatment outcomes, with various approaches being explored for targeting hypoxia in tumors.
Tumour hypoxia is significantly correlated with patient survival and treatment outcomes. At the molecular level, hypoxia is a major driving factor for tumour progression and aggressiveness. Despite the accumulative scientific and clinical efforts to target hypoxia, there is still a need to find specific treatments for tumour hypoxia. In this review, we discuss a variety of approaches to alter the low oxygen tumour microenvironment or hypoxia pathways including carbogen breathing, hyperthermia, hypoxia-activated prodrugs, tumour metabolism and hypoxia-inducible factor (HIF) inhibitors. The recent advances in technology and biological understanding reveal the importance of revisiting old therapeutic regimens and repurposing their uses clinically.
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