Expression of SARS-CoV-2 Spike Protein Receptor Binding Domain on Recombinant B. subtilis on Spore Surface: A Potential COVID-19 Oral Vaccine Candidate

Review Immunology

Deciphering Vaccines for COVID-19: where do we stand today?

Tushar Baviskar et al.

Summary: COVID-19, caused by SARS-CoV-2, has impacted over 200 nations globally. Efforts are being made worldwide to develop vaccines to combat the rapid transmission of this virus.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2021)

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Editorial Material Medicine, General & Internal

The European Medicines Agency's EU conditional marketing authorisations for COVID-19 vaccines

Marco Cavaleri et al.

LANCET (2021)

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Article Multidisciplinary Sciences

Vaccinology in the post-COVID-19 era

Rino Rappuoli et al.

Summary: The COVID-19 pandemic highlights the importance of vaccines, with advancements in technology allowing for unprecedented speed in vaccine development. New vaccine technologies accelerated by the urgency of COVID-19 may also hold the key to addressing other health priorities in the post-pandemic world.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Physiology

Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure syndromes

Sundareswaran Loganathan et al.

Summary: COVID-19 mainly affects the lungs, progressing to pneumonia and acute respiratory distress syndrome (ARDS) through the ACE2 receptor, spreading to various organs. Cytokine storm aggravates inflammation, leading to multiple organ dysfunction. This study provides insights for clinicians and scientists to combat COVID-19.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2021)

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Review Virology

Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design

Xuhua Xia

Summary: This article delves into the structure and function of the spike protein in SARS-CoV-2, aiming to enhance the mechanistic understanding of how it mediates cell entry and transmission, as well as discussing important issues related to vaccine development and the emergence of viral variants.

VIRUSES-BASEL (2021)

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Article Virology

Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

Jingyou Yu et al.

JOURNAL OF VIROLOGY (2021)

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Review Medicine, General & Internal

Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation, and deployment

Olivier J. Wouters et al.

Summary: The COVID-19 pandemic may not end globally until vaccines that protect against severe disease and drive herd immunity are widely distributed. While vaccines have been authorized for human use in many countries, achieving global control of COVID-19 requires not only licensed vaccines but also mass production, affordable pricing, global allocation, and wide local deployment.

LANCET (2021)

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Editorial Material Infectious Diseases

Adjuvantation helps to optimise COVID-19 vaccine candidate

Jing-Xin Li et al.

LANCET INFECTIOUS DISEASES (2021)

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Review Medicine, Research & Experimental

DNA vaccines against COVID-19: Perspectives and challenges

Marcelle Moura Silveira et al.

Summary: The urgent need for COVID-19 vaccines has led to a focus on DNA vaccines as a promising alternative due to their ability to elicit strong immune responses and production advantages. This review summarizes the current research and advancements of DNA vaccines against COVID-19, with a particular emphasis on progress in clinical trials.

LIFE SCIENCES (2021)

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Editorial Material Multidisciplinary Sciences

Market design to accelerate COVID-19 vaccine supply

Juan Camilo Castillo et al.

SCIENCE (2021)

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Article Nutrition & Dietetics

Safety Assessment of Bacillus subtilis MB40 for Use in Foods and Dietary Supplements

Jessica L. Spears et al.

Summary: The safety and tolerability of the unique strain Bacillus subtilis MB40 was assessed through in silico, in vitro, and in vivo studies. The study confirmed the absence of undesirable genetic elements encoding toxins and antibiotic resistance, and found that MB40 was well tolerated in both rats and healthy human volunteers. Based on the research, it was concluded that Bacillus subtilis MB40 does not pose any human health concerns under the tested conditions.

NUTRIENTS (2021)

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Review Immunology

SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates

Nikolaos C. Kyriakidis et al.

Summary: The new SARS-CoV-2 virus is rapidly spreading worldwide, causing the COVID-19 pandemic with more than 1.866 million deaths. Over 64 vaccine candidates are being developed globally, aiming to induce antibodies to prevent viral entry. Thirteen vaccine candidates are currently in Phase 3 clinical trials, showing promising progress towards approval for large-scale immunizations.

NPJ VACCINES (2021)

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Article Microbiology

Shelf Life and Simulated Gastrointestinal Tract Survival of Selected Commercial Probiotics During a Simulated Round-Trip Journey to Mars

Patricia Fajardo-Cavazos et al.

Summary: The study found that probiotics, particularly those consisting of bacterial spores such as Bacillus subtilis, could be a viable option for improving gastrointestinal health during long-duration human space travel.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Microbiology

Bacillus subtilis biofilm formation and social interactions

Sofia Arnaouteli et al.

Summary: This Review provides an overview of biofilm composition and formation in Bacillus subtilis, highlighting the molecular details of the biofilm matrix, regulatory pathways, and beneficial outcomes associated with biofilms. The research on biofilms is informing microbial evolution and ecology, aiding in the development of beneficial applications and advancing our understanding of concepts of microbial evolution and community behavior.

NATURE REVIEWS MICROBIOLOGY (2021)

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Review Chemistry, Multidisciplinary

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development

Yingzhu Li et al.

Summary: The report examines a significant number of vaccine candidates for the COVID-19 pandemic that emerged last year, discussing their technological advantages and disadvantages, the use of adjuvants and delivery systems, and providing insights into their future direction.

ACS CENTRAL SCIENCE (2021)

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Editorial Material Immunology

Access to and equitable distribution of COVID-19 vaccine in low-income countries

Krishna Prasad Acharya et al.

NPJ VACCINES (2021)

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Review Chemistry, Medicinal

COVID-19 Vaccines: A Review of the Safety and Efficacy of Current Clinical Trials

Zhi-Peng Yan et al.

Summary: Various strategies, including vaccine development, have been designed to contain the COVID-19 pandemic. This study reviews the most recent data of 12 vaccines to evaluate their efficacy, safety profile, and usage in various populations, highlighting the importance of comparing protective efficacy and risks of vaccination for global control through herd immunity.

PHARMACEUTICALS (2021)

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Review Medicine, Research & Experimental

The multifunctionality of expression systems in Bacillus subtilis: Emerging devices for the production of recombinant proteins

Caio Coutinho de Souza et al.

Summary: Bacillus subtilis is a successful host for producing recombinant proteins due to its GRAS status and remarkable ability to absorb exogenous DNA. Various genetic engineering strategies have been developed to enhance production efficiency and reduce costs. This expression system is widely used in academic research and industry.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

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Review Immunology

COVID-19 vaccines and thrombosis with thrombocytopenia syndrome

Chih-Cheng Lai et al.

Summary: TTS mimics autoimmune heparin-induced thrombocytopenia and should be treated with non-heparin anticoagulants if the platelet count is above a certain level. Education on TTS symptoms is crucial for patients receiving COVID-19 vaccines.

EXPERT REVIEW OF VACCINES (2021)

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Letter Health Care Sciences & Services

Emergency use authorization (EUA), conditional marketing authorization (CMA), and the precautionary principle at the time of COVID-19 pandemic

Luca Roncati et al.

JOURNAL OF PUBLIC HEALTH POLICY (2021)

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Article Infectious Diseases

Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial

Shipo Wu et al.

Summary: The study evaluated the safety and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine in adults without COVID-19 from China. It found that the aerosol vaccine was well tolerated, and two doses elicited neutralising antibody responses similar to one dose of intramuscular injection. An aerosolised booster vaccination at 28 days after the first intramuscular injection induced strong IgG and neutralising antibody responses. The efficacy and cost-effectiveness of aerosol vaccination should be evaluated in future studies.

LANCET INFECTIOUS DISEASES (2021)

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Review Biochemistry & Molecular Biology

Review of Covid-19 vaccine clinical trials ? A puzzle with missing pieces

Hang Fai Kwok

Summary: A year after the initial outbreak of Covid-19 pandemic, several Phase III clinical trials investigating vaccine safety and efficacy have been published. Vaccine candidates developed by different research groups with various technologies, but many questions remain, especially for specific subgroups.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Immunology

Viral targets for vaccines against COVID-19

Lianpan Dai et al.

Summary: The urgent need for vaccines to control the COVID-19 pandemic has led to the rapid development of multiple vaccine candidates, with some showing positive results in late-stage clinical trials. This article discusses the viral elements used in these candidates, the reasons why they are good targets for the immune system, and their implications for protective immunity. Dai and Gao highlight the importance of selecting the right viral targets in vaccine development to ensure an effective immune response and the overall safety and efficacy of the vaccine.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Fisheries

The effects of dietary Bacillus subtilis on immune response, hematological parameters, growth performance, and resistance of juvenile olive flounder (Paralichthys olivaceus) against Streptococcus iniae

Chorong Lee et al.

JOURNAL OF THE WORLD AQUACULTURE SOCIETY (2020)

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Article Multidisciplinary Sciences

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan et al.

SCIENCE (2020)

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Article Veterinary Sciences

Dietary Supplementation With Bacillus subtilis Direct-Fed Microbials Alters Chicken Intestinal Metabolite Levels

Inkyung Park et al.

FRONTIERS IN VETERINARY SCIENCE (2020)

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Review Oncology

COVID-19 Outbreak: An Overview

Marco Ciotti et al.

CHEMOTHERAPY (2020)

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Review Chemistry, Multidisciplinary

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Yuan Huang et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Review Immunology

COVID-19 pathophysiology: A review

Koichi Yuki et al.

CLINICAL IMMUNOLOGY (2020)

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Article Veterinary Sciences

Bacillus subtilis spore vaccines displaying protective antigen induce functional antibodies and protective potency

Yeonsu Oh et al.

BMC VETERINARY RESEARCH (2020)

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Editorial Material Medicine, Research & Experimental

SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines

Giovanni Salvatori et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Multidisciplinary Sciences

A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Jingyun Yang et al.

NATURE (2020)

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Review Pediatrics

Vaccines for COVID-19: The current state of play

Archana Koirala et al.

PAEDIATRIC RESPIRATORY REVIEWS (2020)

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Review Immunology

COVID-19 Vaccines: Should We Fear ADE?

Scott B. Halstead et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Review Biotechnology & Applied Microbiology

Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine

Yuan Su et al.

MICROBIAL CELL FACTORIES (2020)

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Editorial Material Public, Environmental & Occupational Health

Preparing for COVID-19 vaccine safety surveillance: A United States perspective

Kevin Haynes

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2020)

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Review Biotechnology & Applied Microbiology

Role of antibody-dependent enhancement (ADE) in the virulence of SARS-CoV-2 and its mitigation strategies for the development of vaccines and immunotherapies to counter COVID-19

Kumaragurubaran Karthik et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

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Article Immunology

Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico Analysis

Hamza Arshad Dar et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2020)

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Review Veterinary Sciences

Application of Bacillus subtilis as a live vaccine vector: A review

Penghao Lv et al.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2020)

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Article Biotechnology & Applied Microbiology

Advances on systems metabolic engineering of Bacillus subtilis as a chassis cell

Mengjie Xiang et al.

SYNTHETIC AND SYSTEMS BIOTECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

Zezhong Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Agriculture, Dairy & Animal Science

Evaluation of the Effect of Bacillus Subtilis and Pediococcus Acidilactici Mix on Serum Biochemistry, Growth Promotation of Body and Visceral Organs in Lohmann Brown Chicks

W. Yu et al.

BRAZILIAN JOURNAL OF POULTRY SCIENCE (2020)

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Article Veterinary Sciences

Bacillus subtilis spores as adjuvants against avian influenza H9N2 induce antigen-specific antibody and T cell responses in White Leghorn chickens

Ji Eun Lee et al.

VETERINARY RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn piglets

Jialu Wang et al.

BIOSCIENCE REPORTS (2019)

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Review Biotechnology & Applied Microbiology

Bacillus subtilis Spore Surface Display Technology: A Review of Its Development and Applications

Guoyan Zhang et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2019)

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Review Biology

Bacillus subtilis: A plant-growth promoting rhizobacterium that also impacts biotic stress

Abeer Hashem et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Article Food Science & Technology

Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier

Na-Kyoung Lee et al.

FOOD SCIENCE AND BIOTECHNOLOGY (2019)

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Article Fisheries

Characterization of Bacillus subtilis from gastrointestinal tract of hybrid Hulong grouper (Epinephelus fuscoguttatus x E-lanceolatus) and its effects as probiotic additives

Sheng Zhou et al.

FISH & SHELLFISH IMMUNOLOGY (2019)

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Article Cell Biology

An engineered E-coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Caroline B. Kurtz et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Microbiology

The effects of supplementation of Bacillus subtilis and Bacillus coagulans spores on the intestinal microflora and growth performance in rat

Somaye Mazkour et al.

IRANIAN JOURNAL OF MICROBIOLOGY (2019)

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Review Biotechnology & Applied Microbiology

Bacillus probiotics: an alternative to antibiotics for livestock production

S. Mingmongkolchai et al.

JOURNAL OF APPLIED MICROBIOLOGY (2018)

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Article Multidisciplinary Sciences

Supplemental Bacillus subtilis DSM 32315 manipulates intestinal structure and microbial composition in broiler chickens

Youbiao Ma et al.

SCIENTIFIC REPORTS (2018)

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Review Microbiology

Bacillus As Potential Probiotics: Status, Concerns, and Future Perspectives

Fouad M. F. Elshaghabee et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Article Immunology

Bacillus subtilis Improves Immunity and Disease Resistance in Rabbits

Mengjiao Guo et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Microbiology

Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults

A. Hanifi et al.

BENEFICIAL MICROBES (2015)

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Review Microbiology

Germination of Spores of Bacillus Species: What We Know and Do Not Know

Peter Setlow

JOURNAL OF BACTERIOLOGY (2014)

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Article Biotechnology & Applied Microbiology

A system of vectors for Bacillus subtilis spore surface display

Adam Iwanicki et al.

MICROBIAL CELL FACTORIES (2014)

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Article Multidisciplinary Sciences

Bacillus subtilis Spores as Vaccine Adjuvants: Further Insights into the Mechanisms of Action

Renata Damasio de Souza et al.

PLOS ONE (2014)

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Article Biochemical Research Methods

Use of IPTG-inducible promoters for anchoring recombinant proteins on the Bacillus subtilis spore surface

Quynh Anh Nguyen et al.

PROTEIN EXPRESSION AND PURIFICATION (2014)

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Article Biotechnology & Applied Microbiology

New stable anchor protein and peptide linker suitable for successful spore surface display in B. subtilis

Krzysztof Hinc et al.

MICROBIAL CELL FACTORIES (2013)

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Proceedings Paper Energy & Fuels

Toxicological and Safety Evaluation of Bacillus subtilis Strain Tpb55

Zhang Cheng-wei et al.

ENVIRONMENTAL PROTECTION AND RESOURCES EXPLOITATION, PTS 1-3 (2013)

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Article Biotechnology & Applied Microbiology

Thrombolytic effects of Douchi Fibrinolytic enzyme from Bacillus subtilis LD-8547 in vitro and in vivo

Jun Yuan et al.

BMC BIOTECHNOLOGY (2012)

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Article Immunology

Killed Bacillus subtilis spores as a mucosal adjuvant for an H5N1 vaccine

Manki Song et al.

VACCINE (2012)

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Article Immunology

Evaluation of Oral Immunization with Recombinant Avian Influenza Virus HA1 Displayed on the Lactococcus lactis Surface and Combined with the Mucosal Adjuvant Cholera Toxin Subunit B

Han Lei et al.

CLINICAL AND VACCINE IMMUNOLOGY (2011)

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Article Biotechnology & Applied Microbiology

Expression and display of UreA of Helicobacter acinonychis on the surface of Bacillus subtilis spores

Krzysztof Hinc et al.

MICROBIAL CELL FACTORIES (2010)

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Article Virology

Immunoprotection against influenza H5N1 virus by oral administration of enteric-coated recombinant Lactococcus lactis mini-capsules

Han Lei et al.

VIROLOGY (2010)

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Article Immunology

Bacillus subtilis spores: A novel microparticle adjuvant which can instruct a balanced Th1 and Th2 immune response to specific antigen

Andrew G. C. Barnes et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2007)

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Article Immunology

Stable episomal expression system under control of a stress inducible promoter enhances the immunogenicity of Bacillus subtilis as a vector for antigen delivery

JD Paccez et al.

VACCINE (2006)

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Article Biotechnology & Applied Microbiology

A procedure for high-yield spore production by Bacillus subtilis

SM Monteiro et al.

BIOTECHNOLOGY PROGRESS (2005)

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Article Multidisciplinary Sciences

Immunogenicity in humans of an edible vaccine for hepatitis B

Y Thanavala et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Review Biochemistry & Molecular Biology

Developments in the use of Bacillus species for industrial production

M Schallmey et al.

CANADIAN JOURNAL OF MICROBIOLOGY (2004)

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Article Immunology

Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants

M Pizza et al.

VACCINE (2001)

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Review Biochemistry & Molecular Biology

Production of first generation adenovirus vectors: a review

X Danthinne et al.

GENE THERAPY (2000)

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Expression of SARS-CoV-2 Spike Protein Receptor Binding Domain on Recombinant B. subtilis on Spore Surface: A Potential COVID-19 Oral Vaccine Candidate

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