New-Onset and Relapsed Kidney Histopathology Following COVID-19 Vaccination: A Systematic Review

Summary: Severe acute respiratory syndrome coronavirus 2 (SAR S-CoV-2) is still spreading worldwide, driving the largest vaccination campaign in human history. Although the vaccines have been found to be safe and effective, rare side effects continue to arise. A case of new-onset renal-limited ANCA-associated vasculitis (AAV) in a 78-year-old woman post Pfizer-BioNTech COVID-19 vaccination highlights the need for ongoing surveillance for similar complications.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Article Urology & Nephrology

Minimal Change Disease With Severe Acute Kidney Injury Following the Oxford-AstraZeneca COVID-19 Vaccine: A Case Report

Simon Leclerc et al.

Summary: This case report describes a patient who developed minimal change disease (MCD) and severe acute kidney injury (AKI) following the Oxford-AstraZeneca COVID-19 vaccine. Treatment with glucocorticoids improved kidney function and proteinuria. Further research is needed to determine the association between MCD and COVID-19 vaccination.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Editorial Material Geriatrics & Gerontology

Efficacy and safety of COVID-19 vaccines in older people

Roy L. Soiza et al.

Summary: The safety and efficacy of COVID-19 vaccines in older people are crucial for their success, but there is currently a lack of data. While some Phase III trials have made efforts to recruit older people, those with co-morbidities and frailty have still been largely excluded. Older people, their carers, and healthcare professionals will need to make decisions on vaccination acceptance based on limited evidence.

AGE AND AGEING (2021)

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Review Biochemistry & Molecular Biology

Adaptive immunity to SARS-CoV-2 and COVID-19

Alessandro Sette et al.

Summary: The adaptive immune system, consisting of B cells, CD4(+) T cells, and CD8(+) T cells, plays varying roles in different viral infections and vaccines. Studies are showing that CD4(+) T cells, CD8(+) T cells, and neutralizing antibodies all play a part in controlling SARS-CoV-2 in COVID-19 cases, emphasizing the importance of understanding adaptive immunity in combating the disease.

CELL (2021)

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Article Biochemistry & Molecular Biology

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer et al.

Summary: A single dose of the ChAdOx1 nCoV-19 vaccine can induce favorable immune responses that may help control or prevent SARS-CoV-2 infection.

NATURE MEDICINE (2021)

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Letter Urology & Nephrology

Relapse of class V lupus nephritis after vaccination with COVID-19 mRNA vaccine

Katharina Tuschen et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Scleroderma renal crisis following mRNA vaccination against SARS-CoV-2

Julie Oniszczuk et al.

KIDNEY INTERNATIONAL (2021)

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Editorial Material Urology & Nephrology

COVID-19 vaccines and kidney disease

Martin Windpessl et al.

Summary: Patients with kidney diseases should have priority for COVID-19 vaccination and highly potent vaccines are preferred due to lower vaccine responses in this population.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Urology & Nephrology

Minimal Change Disease Following the Pfizer-BioNTech COVID-19 Vaccine

Larissa Lebedev et al.

Summary: A 50-year-old man developed minimal change disease (MCD) with nephrotic syndrome and acute kidney injury (AKI) shortly after receiving his first dose of the Pfizer-BioNTech COVID-19 vaccine. Treatment with prednisone was initiated and kidney function gradually improved, eventually returning to normal. While the association between the vaccine and MCD is temporal and by exclusion, further reports are needed to evaluate the true incidence of this potential vaccine side effect.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Letter Urology & Nephrology

An Additional Case of Minimal Change Disease Following the Pfizer-BioNTech COVID-19 Vaccine

Rutger J. Maas et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Letter Urology & Nephrology

Acute rejection after anti-SARS-CoV-2 mRNA vaccination in a patient who underwent a kidney transplant

Arnaud Del Bello et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

A case of gross hematuria and IgA nephropathy flare-up following SARS-CoV-2 vaccination

Shab E. Gul Rahim et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Minimal change disease and acute kidney injury following the Pfizer-BioNTech COVID-19 vaccine

Vivette D. D'Agati et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Relapse of primary membranous nephropathy after inactivated SARS-CoV-2 virus vaccination

Mehmet Fethullah Aydin et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Minimal change disease relapse following SARS-CoV-2 mRNA vaccine

Delphine Kervella et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Relapse of Minimal Change Disease Following the Pfizer-BioNTech COVID-19 Vaccine

Hirotaka Komaba et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Article Urology & Nephrology

Minimal change disease following vaccination for SARS-CoV-2

Nicoletta Mancianti et al.

JOURNAL OF NEPHROLOGY (2021)

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Letter Urology & Nephrology

IgA nephropathy presenting as macroscopic hematuria in 2 pediatric patients after receiving the Pfizer COVID-19 vaccine

Christian Hanna et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Anti-GBM nephritis with mesangial IgA deposits after SARS-CoV-2 mRNA vaccination

Allan Sacker et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Relapse of IgG4-related nephritis following mRNA COVID-19 vaccine

Christophe Masset et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Is COVID-19 vaccination unmasking glomerulonephritis?

Hui Zhuan Tan et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Histologic correlates of gross hematuria following Moderna COVID-19 vaccine in patients with IgA nephropathy

Satoru Kudose et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

ANCA glomerulonephritis after the Moderna COVID-19 vaccination

Arjun Sekar et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Gross hematuria following vaccination for severe acute respiratory syndrome coronavirus 2 in 2 patients with IgA nephropathy

Lavinia Negrea et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

De novo vasculitis after mRNA-1273 (Moderna) vaccination

Manuel A. Anderegg et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Minimal change disease following the Moderna mRNA-1273 SARS-CoV-2 vaccine

Amy Holzworth et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Granulomatous vasculitis after the AstraZeneca anti-SARS-CoV-2 vaccine

Valentine Gillion et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Gross hematuria following SARS-CoV-2 vaccination in patients with IgA nephropathy

Peggy Perrin et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Relapse of minimal change disease following the AstraZeneca COVID-19 vaccine

Clare Morlidge et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Letter regarding Minimal change disease relapse following SARS-CoV-2 mRNA vaccine

Nora Schwotzer et al.

KIDNEY INTERNATIONAL (2021)

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Letter Urology & Nephrology

Post-vaccinal minimal change disease

Jari Weijers et al.

KIDNEY INTERNATIONAL (2021)

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Article Medicine, General & Internal

Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting

Noam Barda et al.

Summary: The study found that after receiving the BNT162b2 vaccine, most adverse events were not associated with an increased risk, although there was a slight increase in the risk of myocarditis. On the other hand, infection with the Covid-19 virus significantly increased the risk of many serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months

S. J. Thomas et al.

Summary: BNT162b2 vaccine remains highly effective and safe over the course of 6 months post-vaccination, with efficacy rates ranging from 86% to 100% across different demographics and risk factors for Covid-19. The vaccine also shows a high efficacy against severe disease, with particularly promising results observed in South Africa against the B.1.351 variant.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Human IgG and IgA responses to COVID-19 mRNA vaccines

Adam Wisnewski et al.

Summary: Study on 4 subjects showed that COVID-19 mRNA vaccines effectively induce spike antigen-specific IgG and IgA, but there are marked differences in their persistence in serum.

PLOS ONE (2021)

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Article Microbiology

Renal Thrombotic Microangiopathy in Concurrent COVID-19 Vaccination and Infection

Marco De Fabritiis et al.

Summary: This case report describes a 35-year-old male who developed nephrotic proteinuria and microhematuria following the first dose of BNT162b2 COVID-19 vaccine and COVID-19 diagnosis. After high-dose steroid treatment, complete remission of proteinuria was achieved in a few weeks. The association of renal thrombotic microangiopathy with COVID-19 has been described previously, but the correlation with COVID-19 vaccine is a novel finding.

PATHOGENS (2021)

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Letter Urology & Nephrology

Minimal change disease following vaccination with CoronaVac

Ahmet Burak Dirim et al.

CLINICAL KIDNEY JOURNAL (2021)

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Article Urology & Nephrology

Minimal change disease soon after Pfizer-BioNTech COVID-19 vaccination

Seiji Kobayashi et al.

Summary: This case report describes the onset of minimal change disease (MCD) in a patient after receiving the second dose of the Pfizer-BioNTech mRNA vaccine for COVID-19. The patient achieved complete remission after treatment. While the definite causality between the vaccine and MCD is unclear, awareness of potential adverse effects of mRNA vaccines is crucial for determining their true incidence and frequency.

CLINICAL KIDNEY JOURNAL (2021)

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Article Urology & Nephrology

IgA Nephropathy After SARS-CoV-2 Vaccination

Matthew Abramson et al.

Summary: This case report presents the first diagnosed case of IgA nephropathy following SARS-CoV-2 vaccination, suggesting a potential immunological mechanism and emphasizing the importance of understanding and monitoring immune responses.

KIDNEY MEDICINE (2021)

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Review Medicine, General & Internal

New-onset Nephrotic Syndrome after Janssen COVID-19 Vaccination: a Case Report and Literature Review

Jeong Hoon Lim et al.

Summary: A 51-year-old man developed nephrotic syndrome secondary to minimal change disease after receiving the Ad26.COV.2 (Janssen) vaccine. Clinicians should be cautious about potential renal effects of COVID-19 vaccines.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

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Letter Urology & Nephrology