Effectiveness of COVID-19 Vaccines against Delta Variant (B.1.617.2): A Meta-Analysis

Article Infectious Diseases

Effectiveness of inactivated COVID-19 vaccines against severe illness in B.1.617.2 (Delta) variant-infected patients in Jiangsu, China

Zhiliang Hu et al.

Summary: Full vaccination with inactivated vaccines is highly effective in preventing severe illness in Delta variant-infected patients, while partial vaccination does not offer significant protection.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

添加到收藏夹

Review Virology

Potency of BNT162b2 and mRNA-1273 vaccine-induced neutralizing antibodies against severe acute respiratory syndrome-CoV-2 variants of concern: A systematic review of in vitro studies

Maryam Noori et al.

Summary: This study systematically reviewed 36 recent in vitro studies to evaluate the effectiveness of neutralizing antibodies induced by BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2 variants. The results showed that the B.1.351 variant had the lowest sensitivity to neutralizing antibodies, while the B.1.1.7 variant had the highest sensitivity.

REVIEWS IN MEDICAL VIROLOGY (2022)

添加到收藏夹

Article Infectious Diseases

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial

Shengli Xia et al.

Summary: The inactivated SARS-CoV-2 vaccine, BBIBP-CorV, demonstrated safety and immunogenicity in two age groups. Humoral responses against SARS-CoV-2 were induced in all vaccine recipients by day 42. A two-dose immunisation with 4 mu g vaccine on days 0 and 21 or days 0 and 28 achieved higher neutralising antibody titres compared to other dosing schedules.

LANCET INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Microbiology

An Observational Laboratory-Based Assessment of SARS-CoV-2 Molecular Diagnostics in Benin, Western Africa

Anna-Lena Sander et al.

Summary: Limited by insufficient diagnostic capacity, the spread of SARS-CoV-2 in Africa has been challenging. An increase in COVID-19-related diagnostic workload in the central laboratory of Benin, Western Africa, was observed, with genomic surveillance showing diverse SARS-CoV-2 lineages introduced by travelers. The validated diagnostic kit exhibited high sensitivity and specificity, highlighting the burden on national reference laboratories in resource-limited settings.

MSPHERE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar

Patrick Tang et al.

Summary: mRNA COVID-19 vaccines demonstrate high effectiveness in preventing severe outcomes and death caused by the Delta variant in Qatar, despite lower effectiveness at blocking infection.

NATURE MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK

Koen B. Pouwels et al.

Summary: A large, community-based study in the United Kingdom indicates that the effectiveness of BNT162b2 and ChAdOx1 vaccines against SARS-CoV-2 infections with symptoms or high viral burden is reduced with the Delta variant compared to the Alpha variant. Although the effectiveness of two doses is at least as great as protection afforded by prior natural infection, there are significant differences in the dynamics of immunity after the second dose between BNT162b2 and ChAdOx1.

NATURE MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Correlation of SARS-CoV-2-breakthrough infections to time-from-vaccine

Barak Mizrahi et al.

Summary: The study indicates preliminary evidence of waning vaccine effectiveness of BNT162b2 among all age groups above 16, with a higher incidence of infection in those vaccinated earlier in 2021. Further investigation into long-term protection against different strains is warranted.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Microbiology

Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination

Chris Davis et al.

Summary: Vaccines have proven to be effective in controlling hospitalisation and deaths associated with SARS-CoV-2 infection, but the emergence of viral variants with novel antigenic profiles raises concerns. Serum from vaccine recipients showed reduced neutralisation against SARS-CoV-2 variants like B.1.617.1, B.1.617.2, and B.1.351. The BNT162b2 vaccine induced higher neutralising antibody titres compared to the ChAdOx1 vaccine, but both vaccines showed decreased efficacy against certain variants.

PLOS PATHOGENS (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers - Eight US Locations, December 2020-March 2021

Mark G. Thompson et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

添加到收藏夹

Review Immunology

Comparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2

Ian McDonald et al.

Summary: This study provides a comparative evaluation of different vaccine platforms in terms of immunogenicity and efficacy. Vaccines generally result in mild and self-limiting adverse events. Different vaccines show varying levels of immunogenicity and efficacy.

NPJ VACCINES (2021)

添加到收藏夹

Article Health Care Sciences & Services

Assessing COVID-19 Vaccine Hesitancy, Confidence, and Public Engagement: A Global Social Listening Study

Zhiyuan Hou et al.

Summary: The study found that COVID-19 vaccine hesitancy is prevalent worldwide, and negative tweets attract higher engagement on social media; social media users from different regions express different concerns regarding vaccine acceptance, highlighting the need for effective vaccine campaign to boost public confidence and address hesitancy.

JOURNAL OF MEDICAL INTERNET RESEARCH (2021)

添加到收藏夹

Editorial Material Medicine, General & Internal

Considerations in boosting COVID-19 vaccine immune responses

Philip R. Krause et al.

LANCET (2021)

添加到收藏夹

Letter Medicine, General & Internal

SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness

Aziz Sheikh et al.

LANCET (2021)

添加到收藏夹

News Item Multidisciplinary Sciences

COVID VACCINE BOOSTERS: THE MOST IMPORTANT QUESTIONS

Ewen Callaway

Summary: Some countries are considering deploying extra vaccine doses in response to concerns over waning immunity and SARS-CoV-2 variants, but it is still unclear to scientists whether most people need them.

NATURE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar

Hiam Chemaitelly et al.

Summary: A study showed that the mRNA-1273 vaccine is highly effective against the B.1.1.7 and B.1.351 variants of concern, with efficacy rates of 100% and 96.4% respectively. The vaccine's effectiveness increases rapidly in the weeks following the first dose, reaching maximum efficacy after the second dose, providing strong protection against severe COVID-19 outcomes.

NATURE MEDICINE (2021)

添加到收藏夹

Article Medicine, General & Internal

Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile

Alejandro Jara et al.

Summary: A study in Chile involving 10.2 million participants assessed the effectiveness of an inactivated SARS-CoV-2 vaccine developed in China. Fully immunized individuals had vaccine effectiveness of 65.9% for preventing Covid-19 and 87.5% for preventing hospitalization, 90.3% for preventing ICU admission, and 86.3% for preventing death.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

News Item Critical Care Medicine

Lifting of COVID-19 restrictions in the UK and the Delta variant

Talha Khan Burki

LANCET RESPIRATORY MEDICINE (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Effectiveness of Pfizer-BioNTech and Moderna Vaccines in Preventing SARS-CoV-2 Infection Among Nursing Home Residents Before and During Widespread Circulation of the SARS-CoV-2 B.1.617.2 (Delta) Variant — National Healthcare Safety Network, March 1–August 1, 2021

Srinivas Nanduri et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Effectiveness of COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Frontline Workers Before and During B.1.617.2 (Delta) Variant Predominance — Eight U.S. Locations, December 2020–August 2021

Ashley Fowlkes et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Interim Estimates of COVID-19 Vaccine Effectiveness Against COVID-19–Associated Emergency Department or Urgent Care Clinic Encounters and Hospitalizations Among Adults During SARS-CoV-2 B.1.617.2 (Delta) Variant Predominance — Nine States, June–August 2021

Shaun J. Grannis et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Dealing with vaccine hesitancy in Africa: the prospective COVID-19 vaccine context

Aanuoluwapo Adeyimika Afolabi et al.

Summary: In order to enhance the acceptance of COVID-19 vaccines, it is necessary to promote community involvement, improve feedback mechanisms, strengthen multi-sectoral collaboration, and integrate the vaccine into routine immunization programs.

PAN AFRICAN MEDICAL JOURNAL (2021)

添加到收藏夹

Article Immunology

Effectiveness of inactivated SARS-CoV-2 vaccines against the Delta variant infection in Guangzhou: a test-negative case-control real-world study

Xiao-Ning Li et al.

Summary: The two-dose inactivated SARS-CoV-2 vaccine showed an effectiveness of 59.0% to 70.2% against the Delta variant, with higher efficacy among participants aged 40-59 years and in females compared to males in preventing COVID-19 and moderate diseases.

EMERGING MICROBES & INFECTIONS (2021)

添加到收藏夹

Editorial Material Medicine, General & Internal