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Article
Endocrinology & Metabolism
Mikiko Watanabe et al.
Summary: Variables such as increased waist circumference, smoking, hypertension, and longer time elapsed since vaccination were associated with lower antibody titres following COVID-19 mRNA vaccination. This suggests that individuals with central obesity, hypertension, and smoking may benefit from earlier vaccine boosters or different vaccination schedules to ensure adequate immune response.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Infectious Diseases
Arnaud G. L'Huillier et al.
Summary: This study evaluated the persistence of antibodies against SARS-CoV-2 in hospital employees with mild COVID-19, finding that neutralizing antibodies were detectable in almost all participants at 6 months post infection. Anti-RBD antibodies showed better persistence and even increased over time, possibly due to the detection of progressively higher-affinity antibodies.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Letter
Hematology
Evangelos Terpos et al.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Nicholas A. Kennedy et al.
Summary: Infliximab treatment in patients with inflammatory bowel disease results in attenuated serological responses to a single dose of the SARS-CoV-2 vaccine. Delayed second dosing should be avoided in these patients, as vaccination after SARS-CoV-2 infection or a second dose leads to seroconversion in most individuals.
Article
Virology
Annapaola Callegaro et al.
Summary: A single mRNA vaccine dose seems sufficient to provide immunity in individuals with previous SARS-CoV-2 infection, showing similar results to a full vaccine schedule. Adverse events after vaccination were more common after the second dose, with higher frequency in exposed individuals compared to naive ones.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Takahiro Kageyama et al.
Summary: The study aimed to determine antibody responses in healthcare workers following the BNT162b2 mRNA COVID-19 vaccine and identified factors that predict the response. Results showed that healthcare workers have good antibody responses to the vaccine, with factors like immunosuppressive medication, age, and time from vaccination affecting antibody titers.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Multidisciplinary Sciences
Dami A. Collier et al.
Summary: Elderly individuals, especially those above eighty, show lower immune responses and neutralization abilities against variants of concern after the first vaccine dose, but this improves after the second dose. They have higher frequencies of spike-specific memory B cells but reduced somatic hypermutation of class-switched cells. Production of interferon-gamma and interleukin-2 by SARS-CoV-2 spike-specific T cells is lower in older participants, predominantly by CD4 T cells.
Article
Medicine, General & Internal
Moriah Bergwerk et al.
Summary: Among fully vaccinated health care workers, breakthrough infections with SARS-CoV-2 were correlated with neutralizing antibody titers during the peri-infection period. Most breakthrough infections were mild or asymptomatic, although persistent symptoms did occur.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Microbiology
Jia Wei et al.
Summary: A longitudinal study on 45,965 adults in the UK revealed that older individuals, especially those aged >60 years, had lower antibody levels after a single dose of ChAdOx1 or BNT162b2 COVID-19 vaccines. Prioritizing vaccine allocation for those not previously infected and older individuals for the second dose is recommended based on the findings. Further data is needed to fully understand the relationship between quantitative antibody responses and vaccine-mediated protection.
NATURE MICROBIOLOGY
(2021)
Article
Immunology
Yushi Nomura et al.
Summary: This study aimed to evaluate antibody titres 3 months after the second dose of the BNT162b2 COVID-19 vaccine in Japan and found that age and smoking were the most significant factors affecting antibody titres. Particularly, current smoking status was associated with lower antibody titres, suggesting smoking cessation before vaccination may improve vaccine efficacy.
Article
Immunology
Lisa Mueller et al.
Summary: The study compared antibody responses to the BNT162b2 COVID-19 vaccine in young vaccinees below 60 and elderly vaccinees over 80. The elderly group had lower antibody titers and a lower frequency of neutralizing antibodies post-vaccination, indicating a potential need for closer monitoring or different vaccination strategies for this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Health Care Sciences & Services
Paul Naaber et al.
Summary: The study found that antibody levels declined at 12 weeks and 6 months after receiving two doses of BNT162b2 vaccine, with Spike antibody levels at 6 months being similar to those in individuals who received one dose or had recovered from COVID-19. Most individuals developed Spike-specific memory T cell responses, which were lower in those with higher T cell immunosenescence. Antibody response was negatively correlated with age and positively correlated with the total score of vaccination side effects.
LANCET REGIONAL HEALTH-EUROPE
(2021)
Article
Medical Laboratory Technology
Thomas Perkmann et al.
CLINICAL CHEMISTRY
(2020)
News Item
Multidisciplinary Sciences
Heidi Ledford
Review
Microbiology
Petra Zimmermann et al.
CLINICAL MICROBIOLOGY REVIEWS
(2019)
