T Cell/B Cell Interactions in the Establishment of Protective Immunity

Article Allergy

Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation

Josephine Scholz et al.

Summary: Vitamin A signaling via RAR alpha impacts allergen-specific immunoglobulin response by directly affecting B cell differentiation and indirectly by promoting T follicular helper cells.

ALLERGY (2021)

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Article Critical Care Medicine

Tissue-Specific Immunopathology in Fatal COVID-19

David A. Dorward et al.

Summary: In fatal COVID-19 cases, abnormal immune responses were found primarily in the lung and reticuloendothelial system, which were not clearly associated with the virus. Tissue-specific immunopathology in COVID-19 implicates a significant role of immune-mediated, virus-independent mechanisms in severe disease.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Allergy

Defective STING expression potentiates IL-13 signaling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps

Hai Wang et al.

Summary: The study showed that reduced STING expression in eosinophilic nasal polyps impairs STING-dependent type I interferon production and amplifies IL-13 signaling, highlighting the importance of STING in the pathogenesis of CRSwNP.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Immunology

Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses

Young Min Son et al.

Summary: The study reveals a population of tissue-resident helper T cells in the lung, termed as T-RH cells, which play a critical role in promoting the development of protective B cell and CD8(+) T cell responses. These T-RH cells are dependent on transcription factors BCL6 and Bhlhe40 and deliver local help to CD8(+) T cells through IL-21-dependent mechanisms.

SCIENCE IMMUNOLOGY (2021)

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Article Immunology

T resident helper cells promote humoral responses in the lung

Nivedya Swarnalekha et al.

Summary: Following influenza infection, long-lived T-RH cells are established in the lung, dependent on B cells in iBALT, for rapid response to subsequent infections. Deletion of Bcl6 in CD4(+) T cells results in redistribution of T cells and impaired local antibody production.

SCIENCE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Dynamic regulation of TFH selection during the germinal centre reaction

Julia Merkenschlager et al.

Summary: The germinal centre is a dynamic microenvironment where B cells expressing high-affinity antibody variants are selected for clonal expansion by limiting the number of T follicular helper cells. T follicular helper cells undergo antigen-dependent selection throughout the germinal centre reaction, resulting in differential proliferative expansion and contraction. Competition between T follicular helper cell clones is mediated by the affinity of T cell receptors for peptide-major-histocompatibility-complex ligands.

NATURE (2021)

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Article Environmental Sciences

Status and risks of selenium deficiency in a traditional selenium-deficient area in Northeast China

Chenmeng Yang et al.

Summary: Research in Northeast China found that soil selenium deficiency has significantly decreased, but crop products still have low selenium levels due to weak soil-plant transfer. Climate conditions and soil properties were identified as key factors influencing soil selenium distribution, and the challenge remains in ensuring sufficient selenium content in agricultural products for residents in selenium-deficient areas, particularly in China's growing agricultural production environment.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Immunology

Polymeric Pathogen-Like Particles-Based Combination Adjuvants Elicit Potent Mucosal T Cell Immunity to Influenza A Virus

Brock Kingstad-Bakke et al.

Summary: The study demonstrates the successful induction of durable and protective T cell-mediated immunity in the respiratory mucosa of mice using PLGA-based pathogen-like particles (PLPs) loaded with TLR agonists. This has important implications for the development of universal influenza and SARS-CoV-2 vaccines.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

Cyclic Di-Adenosine Monophosphate: A Promising Adjuvant Candidate for the Development of Neonatal Vaccines

Dario Lirussi et al.

Summary: The immature immune system in neonates poses a high risk of infection-related mortality. The use of CDA as a vaccine adjuvant shows superior immune response in neonates, leading to higher antibody levels.

PHARMACEUTICS (2021)

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Article Immunology

Broad Severe Acute Respiratory Syndrome Coronavirus 2 Cell Tropism and Immunopathology in Lung Tissues From Fatal Coronavirus Disease 2019

Suzane Ramos da Silva et al.

Summary: In fatal COVID-19 lungs, a broad SARS-CoV-2 cell tropism was observed, infecting various lung cells and leading to severe tissue damage, excessive inflammation, and thromboembolism. Extensive infiltration of innate immune cells, activation and depletion of adaptive immune cells were also found, contributing to compromised immune responses.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Dermatology

The Pathogenic Role of CD4+ Tissue-Resident Memory T Cells Bearing T Follicular Helper-Like Phenotype in Pemphigus Lesions

Yaru Zou et al.

Summary: The study found an accumulation of CD4(+) tissue-resident memory T cells in pemphigus skin lesions, which expressed a specific set of costimulatory molecules associated with T follicular helper cells and produced IL-17A and IL-21. These cells were found to support autoantibody production and could be a potential target for pemphigus treatment, with the transcription factor IRF4 identified as a key player in autoantibody production.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Multidisciplinary Sciences

The spatial landscape of lung pathology during COVID-19 progression

Andre F. Rendeiro et al.

Summary: Recent studies using high-parameter imaging mass cytometry have provided insights into the cellular composition and spatial architecture of acute lung injury in humans, including injuries derived from SARS-CoV-2 infection. It was found that SARS-CoV-2 predominantly infects alveolar epithelial cells and induces a localized hyperinflammatory cell state associated with lung damage. As COVID-19 progresses, there is increased macrophage extravasation, along with increased numbers of mesenchymal cells and fibroblasts, possibly indicating attempts to repair the damaged lung tissue. The data generated help in developing a biologically interpretable landscape of lung pathology at both macroscopic and single-cell levels, providing a basis for understanding COVID-19 and lung pathology.

NATURE (2021)

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Review Biotechnology & Applied Microbiology

Emerging concepts in the science of vaccine adjuvants

Bali Pulendran et al.

Summary: Adjuvants are vaccine components that enhance the immune response. Recent advances in understanding the molecular mechanisms and systems vaccinology have revitalized the science and development of novel adjuvants for use in vaccines against COVID-19 and future pandemics.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

Marta Ferreira-Gomes et al.

Summary: The study found that in severe COVID-19 patients, plasmablasts shift from IFN to TGF-beta instruction to produce IgA antibodies that are not specific to dominant SARS-CoV-2 antigens.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells

Kavya Rakhra et al.

Summary: Utilizing natural albumin transport to enhance mucosal T-RM generation through vaccination can significantly boost lung immune responses, increase the number of cellular responses, and improve protection against viral or tumor challenges.

SCIENCE IMMUNOLOGY (2021)

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Review Microbiology

Squalene-Based Influenza Vaccine Adjuvants and Their Impact on the Hemagglutinin-Specific B Cell Response

Phuong Nguyen-Contant et al.

Summary: Squalene-based emulsion adjuvants enhance immune responses and antibody production of influenza vaccines, as well as increasing the diversity and affinity of antibodies against influenza hemagglutinin. These adjuvants are widely used and can provide broad protection against influenza virus clades.

PATHOGENS (2021)

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Article Critical Care Medicine

Follicular Helper-like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis

Laura Bauer et al.

Summary: Pulmonary sarcoidosis is driven not only by T-helper type 1 cells and macrophages, but also by T follicular helper-like cells and germinal center-like reactions in the inflamed lung tissue. This new pathomechanism of active T-cell/B-cell cooperation and local production of potentially pathogenic antibodies should be taken into consideration for diagnosis and treatment.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity

Lise Chauveau et al.

Summary: Research has shown that loading cGAMP into viral vaccine vectors enhances their immunogenicity, boosting T-cell responses and specific antibody titres in mice immunization experiments. Additionally, cGAMP-loaded vaccines showed significant protection in virus challenge experiments.

EMBO REPORTS (2021)

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Review Nutrition & Dietetics

Nutrition and immunity: lessons for COVID-19

Philip C. Calder

Summary: The immune system protects individuals from pathogenic organisms, with good nutrition supporting immune response. Older people, individuals living with obesity, and those who are malnourished are at higher risk of impaired immunity, especially after infection with SARS-CoV-2. Studies suggest that individual micronutrients like vitamin D and zinc may play a role in reducing the severity of infection with SARS-CoV-2.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2021)

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Article Multidisciplinary Sciences

The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches

Patricia Avancena et al.

Summary: Antibody affinity maturation occurs in the germinal center, where follicular dendritic cells form a predetermined number of clusters essential for the GC architecture. The magnitude of the GC reaction is restricted by the occupancy of GC niches by GC B cells.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses

Jun Deng et al.

Summary: Leptin levels are associated with reduced vaccine responses, as it promotes T-FH differentiation and IL-21 production. Leptin deficiency impairs T-FH generation and antibody responses, increasing the risk of vaccine failure.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Antibody avidity, persistence, and response to antigen recall: comparison of vaccine adjuvants

Sonia Budroni et al.

Summary: Differences in innate immune 'imprinting' between vaccine adjuvants may mediate dissimilar effects on the quantity and quality of persisting adaptive responses. Specific combinations of immunoenhancers in the adjuvant systems increase antibody persistence and avidity maturation. Different adjuvants have varied effects on the duration and maturity of adaptive immune responses.

NPJ VACCINES (2021)

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Article Medicine, Research & Experimental

Lung-resident memory B cells protect against bacterial pneumonia

Kimberly A. Barker et al.

Summary: The study found that lung-resident memory B cells play a crucial role in lung immunity, quickly producing antibodies after infection to help clear pathogens. These cells are elicited in mice after pneumococcal infections, are present in human lungs, and are involved in pulmonary antibacterial immunity.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Cell Biology

Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors

Carolyn M. Nielsen et al.

Summary: The study compared the effects of two malaria vaccine delivery platforms on specific Tfh cell responses, showing that the protein/AS01(B) platform induces a higher magnitude of cTfh cell response, which correlates more strongly with antibody production. In contrast to viral vectors, the protein/AS01(B) vaccine shows a greater Th2 bias in antibody production.

CELL REPORTS MEDICINE (2021)

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Article Immunology

The CTA1-DD adjuvant strongly potentiates follicular dendritic cell function and germinal center formation, which results in improved neonatal immunization

Sophie Schussek et al.

MUCOSAL IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Prevention of tuberculosis in macaques after intravenous BCG immunization

Patricia A. Darrah et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity

Ji Wang et al.

SCIENCE (2020)

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Article Immunology

Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge

Nina Dieu Nhien Tran Nguyen et al.

NPJ VACCINES (2020)

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Article Cell Biology

CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells

Elena Brenna et al.

CELL REPORTS (2020)

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Review Immunology

The geography of memory B cell reactivation in vaccine-induced immunity and in autoimmune disease relapses

Rama Dhenni et al.

IMMUNOLOGICAL REVIEWS (2020)

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Article Immunology

Adenosine deaminase-1 enhances germinal center formation and functional antibody responses to HIV-1 Envelope DNA and protein vaccines

Ebony Gary et al.

VACCINE (2020)

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Article Immunology

Recombinant Rabies Virus Overexpressing OX40-Ligand Enhances Humoral Immune Responses by Increasing T Follicular Helper Cells and Germinal Center B Cells

Yingying Li et al.

VACCINES (2020)

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Review Immunology

Better Adjuvants for Better Vaccines: Progress in Adjuvant Delivery Systems, Modifications, and Adjuvant-Antigen Codelivery

Zhi-Biao Wang et al.

VACCINES (2020)

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Article Immunology

Conventional type 1 dendritic cells induce TH1, TH1-like follicular helper T cells and regulatory T cells after antigen boost via DEC205 receptor

Fernando Bandeira Sulczewski et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2020)

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Review Immunology

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

Virgil Schijns et al.

IMMUNOLOGICAL REVIEWS (2020)

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Article Immunology

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

Diane G. Carnathan et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates

Sudhir Pai Kasturi et al.

SCIENCE IMMUNOLOGY (2020)

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Article Rheumatology

Unique expansion of IL-21+Tfh and Tph cells under control of ICOS identifies Sjogren's syndrome with ectopic germinal centres and MALT lymphoma

Elena Pontarini et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Article Immunology

Influenza Vaccine-Induced CD4 Effectors Require Antigen Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Antibody Production

Jingya Xia et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Immunology

SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

Katlyn Lederer et al.

IMMUNITY (2020)

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Article Multidisciplinary Sciences

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

Tsun-Yung Kuo et al.

SCIENTIFIC REPORTS (2020)

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Article Microbiology

TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice

Veronique Godot et al.

PLOS PATHOGENS (2020)

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Article Immunology

Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine

Lu Lu et al.

VACCINES (2020)

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Article Immunology

Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependent protection against pulmonary tuberculosis

Claudio Counoupas et al.

NPJ VACCINES (2020)

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Review Immunology

B cell memory: building two walls of protection against pathogens

Munir Akkaya et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Immunology

Tissue-Resident T Cells and Other Resident Leukocytes

David Masopust et al.

Annual Review of Immunology (2019)

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Article Immunology

Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance

Simon Glatigny et al.

JOURNAL OF IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions

Asbjorn Christophersen et al.

NATURE MEDICINE (2019)

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Article Immunology

Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules

Tor Kristian Andersen et al.

NPJ VACCINES (2019)

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Review Biochemistry & Molecular Biology

B Cell Responses: Cell Interaction Dynamics and Decisions

Jason G. Cyster et al.

CELL (2019)

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Article Biochemistry & Molecular Biology

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

Kimberly M. Cirelli et al.

CELL (2019)

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Review Immunology

Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity

Shuting Shi et al.

VACCINE (2019)

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Article Medicine, Research & Experimental

T follicular helper cells in human efferent lymph retain lymphoid characteristics

Laura A. Vella et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Immunology

The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

Danika L. Hill et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Article Multidisciplinary Sciences

Circulating CXCR3+ Tfh cells positively correlate with neutralizing antibody responses in HCV-infected patients

Jian Zhang et al.

SCIENTIFIC REPORTS (2019)

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Article Cell Biology

Monocytes Acquire the Ability to Prime Tissue-Resident T Cells via IL-10-Mediated TGF-β Release

Elizabeth A. Thompson et al.

CELL REPORTS (2019)

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Article Immunology

Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells

Amber Papillion et al.

SCIENCE IMMUNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective CD8+ Lung-Resident Memory T Cells

Frances C. Knight et al.

ACS NANO (2019)

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Article Immunology

The establishment of resident memory B cells in the lung requires local antigen encounter

S. Rameeza Allie et al.

NATURE IMMUNOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid use disorders

Christine Robinson et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2019)

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Article Medicine, Research & Experimental

PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21

Alexandra Bocharnikov et al.

JCI INSIGHT (2019)

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Article Immunology

STAT4 and T-bet control follicular helper T cell development in viral infections

Jason S. Weinstein et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

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Article Immunology

Induction of vaginal-resident HIV-specific CD8 T cells with mucosal prime-boost immunization

H-X Tan et al.

MUCOSAL IMMUNOLOGY (2018)

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Article Immunology

Trigger-happy resident memory CD4+ T cells inhabit the human lungs

A. E. Oja et al.

MUCOSAL IMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

ICOS Costimulation Differentially Affects T Cells in Secondary Lymphoid Organs and Inflamed Tissues

Dana Vu Van et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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Article Immunology

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

Norbert Pardi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

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Article Immunology

Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses

Emilie Seydoux et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Immunology

IL-1β as mucosal vaccine adjuvant: the specific induction of tissue-resident memory T cells improves the heterosubtypic immunity against influenza A viruses

D. Lapuente et al.

MUCOSAL IMMUNOLOGY (2018)

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Article Cell Biology

T follicular helper-like cells contribute to skin fibrosis

Devon K. Taylor et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Cell Biology

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

Marios Koutsakos et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Multidisciplinary Sciences

Activated T follicular helper-like cells are released into blood after oral vaccination and correlate with vaccine specific mucosal B-cell memory

Ana Cardeno et al.

SCIENTIFIC REPORTS (2018)

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Article Immunology

Overcoming the Neonatal Limitations of Inducing Germinal Centers through Liposome-Based Adjuvants Including C-Type Lectin Agonists Trehalose Dibehenate or Curdlan

Maria Vono et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Immunology

Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties

Charlotte Givord et al.

NPJ VACCINES (2018)

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Article Immunology

PD-1 Controls Follicular T Helper Cell Positioning and Function

Jingwen Shi et al.

IMMUNITY (2018)

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Article Immunology

Transient T-bet expression functionally specifies a distinct T follicular helper subset

Difeng Fang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

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Article Immunology

Pulmonary immunization with a recombinant influenza A virus vaccine induces lung resident CD4+ memory T cells that are associated with protection against tuberculosis

Manuela Florido et al.

MUCOSAL IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

Daniel DiToro et al.

SCIENCE (2018)

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Review Immunology

Determination of T Follicular Helper Cell Fate by Dendritic Cells

Jayendra Kumar Krishnaswamy et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

T Follicular Helper-Like Cells in inflamed non-Lymphoid Tissues

Andreas Hutloff

FRONTIERS IN IMMUNOLOGY (2018)

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Article Immunology

Circulating Follicular Helper and Follicular Regulatory T Cells Are Severely Compromised in Human CD40 Deficiency: A Case Report

Maria Pia Cicalese et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Immunology

Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections

Zeb R. Zacharias et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Adjuvants Enhancing Cross-Presentation by Dendritic Cells: The Key to More Effective Vaccines?

Nataschja I. Ho et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Beyond binding: antibody effector functions in infectious diseases

Lenette L. Lu et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Medicine, Research & Experimental

TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25

Elizabeth A. Thompson et al.

JCI INSIGHT (2018)

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Article Cell Biology

Antigen-presenting cell-derived IL-6 restricts the expression of GATA3 and IL-4 by follicular helper T cells

Melanie Hercor et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2017)

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Review Biotechnology & Applied Microbiology

From discovery to licensure, the Adjuvant System story

Nathalie Garcon et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

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Article Immunology

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

Matthias Pauthner et al.

IMMUNITY (2017)

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Article Immunology

Vaccination establishes clonal relatives of germinal center T cells in the blood of humans

Antje Heit et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Multidisciplinary Sciences

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Deepak A. Rao et al.

NATURE (2017)

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Article Cell Biology

Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

Frank Liang et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Review Pharmacology & Pharmacy

An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

Srinivasa Reddy Bonam et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

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Article Multidisciplinary Sciences

Interconnected subsets of memory follicular helper T cells have different effector functions

Assia Asrir et al.

NATURE COMMUNICATIONS (2017)

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Article Rheumatology

Increased CCL25 and T Helper Cells Expressing CCR9 in the Salivary Glands of Patients With Primary Sjogren's Syndrome: Potential New Axis in Lymphoid Neogenesis

Sofie L. M. Blokland et al.

ARTHRITIS & RHEUMATOLOGY (2017)

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Article Immunology

Migratory CD11b+ conventional dendritic cells induce T follicular helper cell-dependent antibody responses

Jayendra Kumar Krishnaswamy et al.

SCIENCE IMMUNOLOGY (2017)

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Article Medicine, Research & Experimental

CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer

Chunyan Gu-Trantien et al.

JCI INSIGHT (2017)

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Article Immunology

Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells

Ramin Sedaghat Herati et al.

SCIENCE IMMUNOLOGY (2017)

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Review Biotechnology & Applied Microbiology

Safety and tolerability evaluation of the use of Montanide ISA (TM) 51 as vaccine adjuvant: A systematic review

Eva van Doorn et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2016)

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Article Pharmacology & Pharmacy

A critical role of T follicular helper cells in human mucosal anti-influenza response that can be enhanced by immunological adjuvant CpG-DNA

A. N. Aljurayyan et al.

ANTIVIRAL RESEARCH (2016)

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Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

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Synthetic TLR4 agonists enhance functional antibodies and CD4+T-cell responses against the Plasmodium falciparum GMZ2.6C multi-stage vaccine antigen

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Different human vaccine adjuvants promote distinct antigenin-dependent immunological signatures tailored to different pathogens

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MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life

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IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs

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Clonal selection in the germinal centre by regulated proliferation and hypermutation

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Human circulating influenza-CD4(+) ICOS1(+)IL-21(+) T cells expand after vaccination, exert helper function, and predict antibody responses

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T-follicular helper cells survive as long-term memory cells

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Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection

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Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers

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Preclinical evaluation of the safety and immunogenicity of a vaccine consisting of Plasmodium falciparum liver-stage antigen 1 with adjuvant AS01B administered alone or concurrently with the RTS,S/AS01B vaccine in rhesus primates

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Lymphoid reservoirs of antigen-specific memory T helper cells

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ICOS deficiency is associated with a severe reduction of CXCR5+ CD4 germinal center Th cells

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Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only

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Novel phenotypes and migratory properties distinguish memory CD4 T cell subsets in lymphoid and lung tissue

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Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help

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The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo

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The cholera toxin-derived CTA1-DD vaccine adjuvant administered intranasally does not cause inflammation or accumulate in the nervous tissues

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