期刊
VACCINES
卷 9, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/vaccines9101074
关键词
follicular helper T cells; peripheral helper T cells; germinal center reaction; vaccination; inflamed tissues; cytokines
资金
- Deutsche Forschungsgemeinschaft [HU 1294/8-1, TRR 130 TP23]
This review discusses the optimization of Tfh cell generation and their interaction with B cells for therapeutic purposes. It also summarizes different T cell subsets, including Tph cells, and highlights the importance of T cell/B cell interaction in non-lymphoid tissues for the generation of protective antibodies.
Follicular helper T cells (Tfh) are the T cell subset providing help to B cells for the generation of high-affinity antibodies and are therefore of key interest for the development of vaccination strategies against infectious diseases. In this review, we will discuss how the generation of Tfh cells and their interaction with B cells in secondary lymphoid organs can be optimized for therapeutic purposes. We will summarize different T cell subsets including Tfh-like peripheral helper T cells (Tph) capable of providing B cell help. In particular, we will highlight the novel concept of T cell/B cell interaction in non-lymphoid tissues as an important element for the generation of protective antibodies directly at the site of pathogen invasion.
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