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From Bench to Field: A Guide to Formulating and Evaluating Anti-Tick Vaccines Delving beyond Efficacy to Effectiveness

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Summary: In the study, reverse vaccinology approaches were used to identify potential vaccine candidates from Rhipicephalus bursa proteins, with nine candidates selected and three peptides chosen as potential vaccine targets. By combining in silico methods with in vivo immunogenicity evaluation, this study demonstrated the potential of these peptides as anti-tick vaccines prior to costly infestation studies on ovine hosts.

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