期刊
VACCINES
卷 9, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/vaccines9101178
关键词
neutrophils; PMN-MDSCs; natural killer cells; tumor metabolism; tumor microenvironment
资金
- Italian Association for Cancer Research (AIRC) [MFAG2019-ID-22818]
- Cariplo Foundation [ID-2019-1609]
- Italian Ministry of Health Ricerca Corrente-IRCCS MultiMedica
- University of Insubria, Fondi di Ateneo per la Ricerca
- assegno di ricerca, by the Italian Ministry of University and Research PRIN 2017 grant [2017NTK4HY]
The article examines the importance of immune cell effector metabolism, focusing on neutrophils and NK cells in the fields of cancer immunology and tumor immunometabolism, and reviews relevant strategies for targeting tumor metabolism.
Leukocytes often undergo rapid changes in cell phenotype, for example, from a resting to an activated state, which places significant metabolic demands on the cell. These rapid changes in metabolic demand need to be tightly regulated to support immune cell effector functions during the initiation and downregulation of an immune response. Prospects for implementing cancer immunotherapy also rest on the idea of optimizing the metabolic profile of immune cell effectors. Here, we examine this issue by focusing on neutrophils and NK cells as cells of increasing interest in cancer immunology and tumor immunometabolism, because they can be targeted or, in the case of NK, used as effectors in immunotherapy. In addition, neutrophils and NK cells have been shown to functionally interact. In the case of neutrophils, we also extended our interest to polymorphonuclear MDSC (PMN-MDSCs), since the granulocytic subset of MDSCs share many phenotypes and are functionally similar to pro-tumor neutrophils. Finally, we reviewed relevant strategies to target tumor metabolism, focusing on neutrophils and NK cells.
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