Willingness to Receive the Booster COVID-19 Vaccine Dose in Poland

Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

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Article Medicine, General & Internal

Acceptance of a COVID-19 Vaccine and Its Related Determinants among the General Adult Population in Kuwait

Yosor Alqudeimat et al.

Summary: The study found that 53.1% of adults in Kuwait were willing to accept a COVID-19 vaccine. Men were more willing than women, those with health-related risk perceptions regarding vaccines were less willing, and individuals who had previously received an influenza vaccine were more likely to accept a COVID-19 vaccine. Willingness to receive the COVID-19 vaccine increased with perceived risk of infection.

MEDICAL PRINCIPLES AND PRACTICE (2021)

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Article Multidisciplinary Sciences

Psychological characteristics associated with COVID-19 vaccine hesitancy and resistance in Ireland and the United Kingdom

Jamie Murphy et al.

Summary: Identifying and understanding COVID-19 vaccine hesitancy within distinct populations may aid future public health messaging. Using nationally representative data from the general adult populations of Ireland and the UK, the study found differences in vaccine hesitancy/resistance between the two countries but similarities in psychological constructs among resistant respondents. Vaccine-resistant individuals in both populations were less likely to obtain information from traditional and authoritative sources and had similar levels of mistrust in these sources compared to vaccine-accepting individuals.

NATURE COMMUNICATIONS (2021)

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Letter Infectious Diseases

The Delta SARS-CoV-2 variant has a higher viral load than the Beta and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19 patients

Elisa Teyssou et al.

JOURNAL OF INFECTION (2021)

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Article Multidisciplinary Sciences

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier et al.

Summary: The B.1.1.7 variant of SARS-CoV-2 exhibited reduced neutralization by vaccines and antibodies from recovered COVID-19 patients, with a more substantial loss seen when introducing the E484K mutation. This mutation poses a threat to the efficacy of the BNT162b2 vaccine.

NATURE (2021)

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Article Immunology

The Perception and Attitudes toward COVID-19 Vaccines: A Cross-Sectional Study in Poland

Piotr Rzymski et al.

Summary: The study demonstrates varying levels of trust in COVID-19 vaccines across producers, with mRNA vaccines being received with high acceptance. It emphasizes the need for effective and continuous science communication when fighting the pandemic.

VACCINES (2021)

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Article Immunology

A Comparison of the Level of Acceptance and Hesitancy towards the Influenza Vaccine and the Forthcoming COVID-19 Vaccine in the Medical Community

Magdalena Grochowska et al.

Summary: Despite the lack of a specific treatment for SARS-CoV-2, vaccinating a large percentage of the global population could be a breakthrough in combating the infection. A study of Polish healthcare workers found that the majority are willing to receive COVID-19 vaccinations, with safety and efficacy being key factors in persuading hesitant individuals. Additionally, while more respondents trusted the influenza vaccine, a higher percentage expressed intent to get vaccinated against COVID-19 in the upcoming season.

VACCINES (2021)

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Article Surgery

Cellular immunity predominates over humoral immunity after homologous and heterologous mRNA and vector-based COVID-19 vaccine regimens in solid organ transplant recipients

Tina Schmidt et al.

Summary: This study found that solid organ transplant recipients had lower levels of SARS-CoV-2-specific antibodies and T cells compared to controls after homologous or heterologous vaccination. However, heterologous vaccination showed promise in improving immune responses in transplant recipients, with higher induction of antibodies and CD4 T cells.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Medicine, General & Internal

Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naive recipients of the BNT162b2 mRNA vaccine versus COVID-19 patients

Ioannis P. Trougakos et al.

Summary: The study revealed that one dose of the BNT162b2 vaccine can trigger robust immune responses in COVID-19 convalescent healthy recipients, while naive recipients require both priming and boosting shots; severe COVID-19 patients exhibit earlier and more intense immune responses, but recovered patients still maintain high antibody titers. Vaccination induces significantly higher and likely more durable antibody titers compared to natural infection, supporting the efficacy of vaccination over natural infection.

BMC MEDICINE (2021)

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Letter Medicine, General & Internal

Age-Dependent Neutralization of SARS-CoV-2 and P.1 Variant by Vaccine Immune Serum Samples

Timothy A. Bates et al.

Summary: This study investigates the correlation between age and neutralizing antibody levels against the SARS-CoV-2 USA-WA1/2020 strain and the P.1 variant after receiving 2 doses of the BNT162b2 vaccine.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Gastroenterology & Hepatology

Analysis of antibody responses after COVID-19 vaccination in liver transplant recipients and those with chronic liver diseases

Paul J. Thuluvath et al.

Summary: The study found that 61% of liver transplant recipients and 24% of patients with liver disease had poor antibody responses after receiving the SARS-CoV-2 vaccine. Immunocompromised status, vaccination with a single dose of Johnson & Johnson vaccine, and use of 2 or more immunosuppressive medications were associated with poor immune responses.

JOURNAL OF HEPATOLOGY (2021)

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Editorial Material Public, Environmental & Occupational Health

The reproductive number of the Delta variant of SARS-CoV-2 is far higher compared to the ancestral SARS-CoV-2 virus

Ying Liu et al.

Summary: The Delta variant is rapidly replacing other strains of SARS-CoV-2, with a higher R-0 value of 5.08 compared to the ancestral strain's 2.79. Increasing vaccine coverage and strengthening public health measures are now more urgent than ever to control the spread of the virus.

JOURNAL OF TRAVEL MEDICINE (2021)

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Editorial Material Medicine, General & Internal

Considerations in boosting COVID-19 vaccine immune responses

Philip R. Krause et al.

LANCET (2021)

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Article Multidisciplinary Sciences

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection

Zijun Wang et al.

Summary: Despite challenges posed by COVID-19 variants, convalescent individuals receiving mRNA vaccines exhibit robust and long-lasting immune responses against circulating SARS-CoV-2 variants, providing hope for effective control of the pandemic.

NATURE (2021)

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Letter Biochemistry & Molecular Biology

COVID-19 boosters in rich nations will delay vaccines for all

Zain Chagla et al.

NATURE MEDICINE (2021)

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Letter Medicine, General & Internal

Three Doses of an mRNA Covid-19 Vaccine in Solid-Organ Transplant Recipients

Nassim Kamar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Preferences for COVID-19 vaccine distribution strategies in the US: A discrete choice survey

Ingrid Eshun-Wilson et al.

Summary: This study identified four distinct preference phenotypes towards COVID-19 vaccines: those who prioritized inherent vaccine features, those concerned about vaccine service delivery, those desiring social proof of vaccine safety and being susceptible to enforcement, and those who were indifferent to vaccine and service delivery features and resisted enforcement. The study suggests that identifying these preference segments is essential to ensure that vaccination services meet the needs of diverse population subgroups and increase vaccination rates.

PLOS ONE (2021)

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News Item Critical Care Medicine

Lifting of COVID-19 restrictions in the UK and the Delta variant

Talha Khan Burki

LANCET RESPIRATORY MEDICINE (2021)

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Article Medicine, Research & Experimental

Rapid, robust, and sustainable antibody responses to mRNA COVID-19 vaccine in convalescent COVID-19 individuals

Sabrina E. Racine-Brzostek et al.

Summary: Longitudinal study investigated SARS-CoV-2 antibody response in individuals with different vaccination and infection status. It was found that individuals without prior COVID-19 infection took longer to generate antibodies after the first vaccine dose, while those previously infected had higher and more persistent antibody levels.

JCI INSIGHT (2021)

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Review Immunology

Thrombotic Thrombocytopenia after COVID-19 Vaccination: In Search of the Underlying Mechanism

Piotr Rzymski et al.

Summary: The rollout of COVID-19 vaccines brings hope for controlling the pandemic, but some vaccines may lead to rare thrombotic events during post-authorization use. The exact causes of these adverse reactions remain unclear, investigations and research are ongoing.

VACCINES (2021)

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Article Immunology

Clinical Characteristics of Hospitalized COVID-19 Patients Who Received at Least One Dose of COVID-19 Vaccine

Piotr Rzymski et al.

Summary: A study analyzing COVID-19 vaccine recipients who were hospitalized with severe cases in Poland found that while deaths and severe cases were rare, they still occurred, especially among individuals with diminished immune responses or non-responders to the vaccine. Close monitoring of high-risk individuals for vaccine failure is recommended.

VACCINES (2021)

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Article Immunology

Changes in Attitudes towards the COVID-19 Vaccine and the Willingness to Get Vaccinated among Adults in Poland: Analysis of Serial, Cross-Sectional, Representative Surveys, January-April 2021

Filip Raciborski et al.

Summary: The study showed that 31.3% of Polish adults were unwilling to receive the COVID-19 vaccine, with significant differences observed by gender and age. The primary concern cited against vaccination was the potential side effects.

VACCINES (2021)

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Article Cardiac & Cardiovascular Systems

The 2020 research pandemic: A bibliometric analysis of publications on COVID-19 and their scientific impact during the first months

Carlos E. Dieguez-Campa et al.

Summary: Through bibliometric analysis of early scientific publications on COVID-19, it was found that the number of publications was significantly correlated with confirmed cases and deaths in each country. This highlights the rapid response of the scientific community in the fight against COVID-19.

ARCHIVOS DE CARDIOLOGIA DE MEXICO (2021)

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Article Immunology

Age-dependent Immune Response to the Biontech/Pfizer BNT162b2 Coronavirus Disease 2019 Vaccination

Lisa Mueller et al.

Summary: The study compared antibody responses to the BNT162b2 COVID-19 vaccine in young vaccinees below 60 and elderly vaccinees over 80. The elderly group had lower antibody titers and a lower frequency of neutralizing antibodies post-vaccination, indicating a potential need for closer monitoring or different vaccination strategies for this population.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Medicine, General & Internal

Attitudes, acceptance and hesitancy among the general population worldwide to receive the COVID-19 vaccines and their contributing factors: A systematic review

Fidelia Cascini et al.

Summary: Acceptance rates of COVID-19 vaccines vary significantly between countries and time points, with Arabian countries showing higher hesitancy rates. Factors contributing to hesitancy include negative perceptions of vaccine efficacy, safety, convenience, and price. Certain socio-demographic groups identified with lower vaccine acceptance rates include women, younger participants, and individuals with lower education level, income, insurance coverage, living in rural areas, and identifying as racial/ethnic minorities.

ECLINICALMEDICINE (2021)

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Article Health Care Sciences & Services

Humoral and cellular immunity to SARS-CoV-2 vaccination in renal transplant versus dialysis patients: A prospective, multicenter observational study using mRNA-1273 or BNT162b2 mRNA vaccine

Julian Stumpf et al.

Summary: The study showed that dialysis patients had a high seroconversion rate after receiving the boost vaccination, while the majority of transplant recipients had impaired humoral responses. The type and number of immunosuppressive drugs, as well as the type of vaccine, were major determinants of seroconversion failure in both dialysis and transplant patients.

LANCET REGIONAL HEALTH-EUROPE (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Petra Mlcochova et al.

Summary: The B.1.617.2 (Delta) variant of SARS-CoV-2 has lower sensitivity to antibodies and higher replication efficiency compared to other lineages, which may contribute to its dominance and reduced vaccine effectiveness, highlighting the need for continued infection control measures post-vaccination.

NATURE (2021)

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Article Medicine, General & Internal

Antibody titers against SARS-CoV-2 decline, but do not disappear for several months

Seiya Yamayoshi et al.

Summary: This longitudinal study on antibody responses against SARS-CoV-2 in symptomatic patients found that IgG titers peaked around 20 days after onset, gradually decreased but maintained for several months. Most patients had neutralizing antibodies at 90 days post-onset, with severe cases having higher initial titers but faster decrease rate.

ECLINICALMEDICINE (2021)

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Article Health Care Sciences & Services