期刊
MICROBIAL GENOMICS
卷 7, 期 11, 页码 -出版社
MICROBIOLOGY SOC
DOI: 10.1099/mgen.0.000703
关键词
Klebsiella pneumoniae; hospital outbreak; antimicrobial resistance; neonatal infection; sub-Saharan Africa; genome sequencing
资金
- LSTM research development grant [RDF160301AC12]
- Wellcome Trust through the MLW Core Grant Training Scheme [206 545]
- ARC DECRA Fellowship [DE180100929]
- Australian Research Council [DE180100929] Funding Source: Australian Research Council
A study conducted in a large public hospital in Malawi identified a multi-drug resistant Klebsiella pneumoniae outbreak in the neonatal unit, which was difficult to treat; genomic characterisation revealed a specific strain implicated in the outbreak, providing valuable molecular information for tracking and characterizing this important hospital pathogen in sub-Saharan Africa.
A special- care neonatal unit from a large public hospital in Malawi was noted as having more frequent, difficult- to- treat infections, and a suspected outbreak of multi- drug- resistant Klebsiella pneumoniae was investigated using genomic characterisation. All K. pneumoniae bloodstream infections (BSIs) from patients in the neonatal ward (n=62), and a subset of K. pneumoniae BSI isolates (n=38) from other paediatric wards in the hospital, collected over a 4 year period were studied. After whole genome sequencing, the strain sequence types (STs), plasmid types, virulence and resistance genes were identified. One ST340 clone, part of clonal complex 258 (CC258) and an ST that drives hospital outbreaks worldwide, harbouring numerous resistance genes and plasmids, was implicated as the likely cause of the outbreak. This study contributes molecular information necessary for tracking and characterizing this important hospital pathogen in sub- Saharan Africa.
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