4.7 Article

Dacarbazine-Loaded Targeted Polymeric Nanoparticles for Enhancing Malignant Melanoma Therapy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Materials Science, Multidisciplinary

Investigation of ibuprofen loading in PEG-PLGA-PEG micelles by coarse-grained DPD simulations

Mihriban Yildiz et al.

Summary: This study investigates the drug encapsulation behavior of a specific copolymer using coarse-grained simulations, which show high efficiency in encapsulating drugs through dissipative particle dynamics simulations.

MRS ADVANCES (2021)

Article Engineering, Environmental

Protonated 2D carbon nitride sensitized with Ce6 as a smart metal-free nanoplatform for boosted acute multimodal photo-sono tumor inactivation and long-term cancer immunotherapy

Mengya Chen et al.

Summary: A smart metal-free two-dimensional nanoplatform was developed for cancer therapy, demonstrating excellent stability, compatibility, and efficacy, enhancing the long-term effects of immunotherapy.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Engineering, Environmental

Targeted exosomes for co-delivery of siFGL1 and siTGF-β1 trigger combined cancer immunotherapy by remodeling immunosuppressive tumor microenvironment

Xing Pei et al.

Summary: This study introduced a combination therapeutic strategy for colorectal cancer by targeting the immune checkpoint LAG-3 ligand FGL1 and the immunosuppressive cytokine TGF-beta 1 simultaneously. The constructed cRGD-Exo/siMix exhibited significant anti-tumor effects by reshaping the tumor microenvironment and boosting anti-tumor immunity, providing a new approach for siRNA delivery in combined cancer immunotherapy.

CHEMICAL ENGINEERING JOURNAL (2021)

Review Chemistry, Multidisciplinary

Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

Zimu Li et al.

Summary: The impermeable barrier of solid tumors poses challenges for the clinical translation of nanomedicine. Surface modification strategies, particularly those utilizing direct contact between surfaces, offer a promising solution for improving penetrability. However, further research is needed to address evaluation methods and existing challenges in this field.

ADVANCED SCIENCE (2021)

Article Chemistry, Multidisciplinary

Charge-reversal biodegradable MSNs for tumor synergetic chemo/ photothermal and visualized therapy

Zimu Li et al.

Summary: A novel nanomedicine, MSN-Man-DOX@PDA-Gd-PEOz, was developed with excellent tumor targeting and penetration abilities, showing outstanding therapeutic effects in vivo and a promising prospect for clinical application.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Chemistry, Applied

Redox-responsive nanoparticles based on Chondroitin Sulfate and Docetaxel prodrug for tumor targeted delivery of Docetaxel

Yimu Li et al.

Summary: A novel redox-responsive nanoparticles were designed for targeted delivery of DTX by combining CS and modified redox-responsive DTX prodrug. The nanoparticles showed increased DTX release in reductive environment, enhanced permeability in tumor tissues, and improved cytotoxicity compared to free DTX. This category of nanoparticles has the potential to be a promising approach for tumor chemotherapy in the future.

CARBOHYDRATE POLYMERS (2021)

Review Biotechnology & Applied Microbiology

Beyond cancer cells: Targeting the tumor microenvironment with gene therapy and armed oncolytic virus

Peter Kok-Ting Wan et al.

Summary: Cancer gene therapies targeting the tumor microenvironment have shown promising results by focusing on strategies that target the cancer stroma, reduce tumor vasculature, and repolarize the immunosuppressive microenvironment. This approach is appealing because the genetically stable TME plays a crucial role in promoting cancer growth, immune tolerance, and resistance to therapies, especially in the presence of multiple mutations in cancers.

MOLECULAR THERAPY (2021)

Article Engineering, Biomedical

Designer exosomes enabling tumor targeted efficient chemo/gene/ photothermal therapy

Jie Wang et al.

Summary: Exosomes, nanosized particles secreted and absorbed by cells, are used as diagnostic and therapeutic platforms in cancer treatment. Combining designer exosomes with chemo/gene/photothermal therapy shows promise in reducing tumor size in animal models.

BIOMATERIALS (2021)

Article Biotechnology & Applied Microbiology

Tumor suppressor immune gene therapy to reverse immunotherapy resistance

Sunil Chada et al.

Summary: The study demonstrates the potential of combining Ad-p53 gene therapy with CD122/132 agonists and immune checkpoint inhibitors to reverse resistance to immunotherapy in aggressive tumors. The triple therapy showed significant synergistic effects and potential curative outcomes, inducing complete tumor remissions and abscopal effects. Ad-p53 treatment enhanced antitumor immune responses, decreased immune-suppressive gene signatures, and identified novel anticancer therapeutic targets.

CANCER GENE THERAPY (2021)

Article Engineering, Environmental

Multimode CaCO3/pneumolysin antigen delivery systems for inducing efficient cellular immunity for anti-tumor immunotherapy

Jie Lu et al.

Summary: This study successfully induced cellular immunity for tumor vaccines by combining the multi-functional vaccine adjuvant pneumolysin (PLY) and carrier calcium carbonate (CaCO3) nanoparticles to construct multimode antigen delivery systems CaCO3/PLY. The minimalist tumor vaccine OVA/CaCO3/PLY exhibited significant anti-tumor efficacy in both preventive and therapeutic aspects, highlighting the promising platform offered by the multimode antigen delivery system CaCO3/PLY.

CHEMICAL ENGINEERING JOURNAL (2021)

Review Biochemistry & Molecular Biology

Quantitative imaging and dynamics of tumor therapy with viruses

Iris Kemler et al.

Summary: Using engineered viruses for tumor therapy is an exciting and novel approach, but success depends on establishing infection and ongoing propagation of the virus within the tumor. Understanding these complex dynamics requires mathematical and computational models as well as noninvasive monitoring methods.

FEBS JOURNAL (2021)

Article Chemistry, Analytical

Pollen-like silica nanoparticles as a nanocarrier for tumor targeted and pH-responsive drug delivery

Rongrong Jin et al.

Summary: Aptamer modified hollow silica nanoparticles with pollen structure were synthesized and used as a nanocarrier for tumor targeted and pH-responsive drug delivery. The nanoparticles showed high drug loading efficiency and pH-responsive releasing efficiency. The special spikes of the nanoparticles enhanced the interaction between cell and drug nanocarriers, leading to increased internalization rate and targeted therapy potential.

TALANTA (2021)

Article Biology

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

S. Jordan Kerns et al.

Summary: This study demonstrated the unprecedented capability of two human Organs-on-Chips in evaluating the safety profile of T-cell bispecific antibodies targeting tumor antigens, predicting TCB safety liabilities based on target expression and antibody affinity. These novel tools broaden research options for understanding engineered therapeutic antibodies and assessing safety in tissues susceptible to adverse events.
Article Nanoscience & Nanotechnology

AS1411-conjugated gold nanoparticles affect cell proliferation through a mechanism that seems independent of nucleolin

Samaneh Kabirian-Dehkordi et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

Article Multidisciplinary Sciences

Dacarbazine nanoparticle topical delivery system for the treatment of melanoma

Abdul Hafeez et al.

SCIENTIFIC REPORTS (2017)

Article Nanoscience & Nanotechnology

Dacarbazine-Loaded Hollow Mesoporous Silica Nanoparticles Grafted with Folic Acid for Enhancing Antimetastatic Melanoma Response

Qianqian Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Review Biochemistry & Molecular Biology

The roles of nucleolin subcellular localization in cancer

Caroline Madeleine Berger et al.

BIOCHIMIE (2015)

Review Nanoscience & Nanotechnology

Recent advances in targeted nanoparticles drug delivery to melanoma

Jun Li et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

Article Multidisciplinary Sciences

Human anti-nucleolin recombinant immunoagent for cancer therapy

Dario Palmieri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Nanoscience & Nanotechnology

Development of nanostructured lipid carrier for dacarbazine delivery

Musallam Almousallam et al.

INTERNATIONAL NANO LETTERS (2015)

Review Oncology

Cell Surface Nucleolin as a Target for Anti-Cancer Therapies

Marina Koutsioumpa et al.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2014)

Article Engineering, Biomedical

Effects of amphiphilic star-shaped poly(ethylene glycol) polymers with a cholic acid core on human red blood cell aggregation

Florence Janvier et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2013)

Article Medicine, General & Internal

Safety and Tumor Responses with Lambrolizumab (Anti-PD-1) in Melanoma

Omid Hamid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Cell & Tissue Engineering

Mesenchymal Stem Cell-Based Tumor-Targeted Gene Therapy in Gastrointestinal Cancer

Qi Bao et al.

STEM CELLS AND DEVELOPMENT (2012)

Article Nanoscience & Nanotechnology

A nanoemulsion formulation of dacarbazine reduces tumor size in a xenograft mouse epidermoid carcinoma model compared to dacarbazine suspension

Srikanth Kakumanu et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

Article Medicine, General & Internal

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Pharmacology & Pharmacy

Formulation of Dacarbazine-Loaded Cubosomes-Part I: Influence of Formulation Variables

Di Bei et al.

AAPS PHARMSCITECH (2009)

Article Dermatology

Cutaneous melanoma: available therapy for metastatic disease

Ahmad A. Tarhini et al.

DERMATOLOGIC THERAPY (2006)