期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.792489
关键词
nucleic acids; unnatural base pairs; unnatural nucleic acids; nanostructures; cascade biocatalysts
资金
- National Natural Science Foundation of China [21978100]
- National Key R&D Program of China [2019YFA0904102]
- Guangdong Provincial Pearl River Talents Program [2019QN01Y228]
- Program for Guangdong Introducing Innovative and Entrepreneurial Teams [2019ZT08Y318]
Nucleic acids play a crucial role in storing and retrieving genetic information in all living organisms, as well as providing materials for artificial nanostructures and scaffolds for constructing high-performance multi-enzyme systems. Introducing unnatural moieties into nucleic acids significantly increases their diversity, expanding the toolbox for making nanomaterials and multi-enzyme system scaffolds.
Nucleic acids underlie the storage and retrieval of genetic information literally in all living organisms, and also provide us excellent materials for making artificial nanostructures and scaffolds for constructing multi-enzyme systems with outstanding performance in catalyzing various cascade reactions, due to their highly diverse and yet controllable structures, which are well determined by their sequences. The introduction of unnatural moieties into nucleic acids dramatically increased the diversity of sequences, structures, and properties of the nucleic acids, which undoubtedly expanded the toolbox for making nanomaterials and scaffolds of multi-enzyme systems. In this article, we first introduce the molecular structures and properties of nucleic acids and their unnatural derivatives. Then we summarized representative artificial nanomaterials made of nucleic acids, as well as their properties, functions, and application. We next review recent progress on constructing multi-enzyme systems with nucleic acid structures as scaffolds for cascade biocatalyst. Finally, we discuss the future direction of applying nucleic acid frameworks in the construction of nanomaterials and multi-enzyme molecular machines, with the potential contribution that unnatural nucleic acids may make to this field highlighted.
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