☆ 4.7 Review

Organ-On-A-Chip: A Survey of Technical Results and Problems

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Recent progress of microfluidic technology for pharmaceutical analysis

Xiaomeng Jia et al.

Summary: This article summarizes recent advances in microfluidic technology for pharmaceutical analysis, focusing on principles, techniques, and applications of pharm-lab-on-a-chip. The trend and challenges of microfluidic technology for pharmaceutical analysis are discussed and prospected.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

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Article Ophthalmology

Organoids and organ chips in ophthalmology

Navid Manafi et al.

Summary: Recent advances in stem cell-derived, self-organizing, three-dimensional miniature organs, such as organoids and organ chips, have shown potential in simulating the complexity of native organ structure and function. They may enhance our understanding of the physiology of different eye structures, explore unknown aspects of ophthalmic disease pathogenesis, and serve as clinically-relevant tools for evaluating ocular therapeutics.

OCULAR SURFACE (2021)

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Review Cardiac & Cardiovascular Systems

Organ-on-a-chip systems for vascular biology

Christian J. Mandrycky et al.

Summary: Organ-on-a-chip platforms involve miniaturization of cell culture systems, enabling novel experimental approaches such as modeling biophysical forces on cells and screening new drugs. Vascular structure is a key feature in these systems, with recent advances focusing on developing vascular models for studying vascular biology and tissue regeneration. Future approaches aim to select fit-for-purpose OOC models to either serve as simple testbeds for therapeutic development or accurately replicate human physiology for specific disease modeling and tissue regeneration.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

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Review Biochemical Research Methods

Organ-on-a-Chip: The Future of Therapeutic Aptamer Research?

Thoa Thi Thanh Tran et al.

Summary: Aptamers, known as chemical antibodies, have high diagnostic and therapeutic value, but their clinical translation has been delayed due to limitations in target selection and lack of crucial information. The use of organ-on-a-chip technology offers a promising solution to enhance the clinical translation of aptamer-based therapeutics.

BIOCHIP JOURNAL (2021)

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Review Chemistry, Analytical

Advancement of Sensor Integrated Organ-on-Chip Devices

Gabriel A. Clarke et al.

Summary: Organ-on-chip devices have brought hope to pharmaceutical and tissue engineering fields, but their limitations in real-time monitoring and sensing capabilities have been realized. By integrating sensors into these devices, the gap in understanding between lab research and the natural world can be bridged.

SENSORS (2021)

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Article Materials Science, Biomaterials

Collagen I Based Enzymatically Degradable Membranes for Organ-on-a-Chip Barrier Models

Yusuf B. Arik et al.

Summary: This study focuses on a microfluidic device integrated with a vitrified membrane made of collagen-I hydrogel for organ-on-chip applications. The biocompatibility of the membrane was confirmed by growing endothelial cells and retinal pigment epithelium on it, and the effects of biochemical degradation were characterized by changes in permeability and topography. Overall, this research presents a bioresponsive membrane for studying disease-related extracellular matrix remodeling in organ-on-chip devices.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Chemistry, Analytical

Design and Fabrication of Organ-on-Chips: Promises and Challenges

Alireza Tajeddin et al.

Summary: The advancement of miniaturization techniques has had a significant impact on various research fields, including bioengineering. The development of 3D cell culture environments and organ-on-chip technologies has provided new possibilities for cell and tissue culture, disease modeling, and drug discovery. While these technologies offer potential alternatives to traditional methods, they also present challenges that require interdisciplinary studies for further development.

MICROMACHINES (2021)

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Article Chemistry, Analytical

Design and Fabrication of Low-Cost Microfluidic Chips and Microfluidic Routing System for Reconfigurable Multi-(Organ-on-a-Chip) Assembly

Sadeq Abu-Dawas et al.

Summary: A low-cost, versatile, and reconfigurable fluidic routing system and chip assembly have been developed, showcasing the custom design of chip-to-chip communication and versatility for various biological models.

MICROMACHINES (2021)

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Review Chemistry, Analytical

3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review

Violeta Carvalho et al.

Summary: Three-dimensional in vitro models, particularly organ-on-a-chip platforms, offer a promising approach for biomedical research, with 3D printing techniques providing advantages in their fabrication. Challenges in integrating sensors in organ-on-a-chip platforms are also investigated and discussed.

SENSORS (2021)

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Review Chemistry, Analytical

A Decade of Organs-on-a-Chip Emulating Human Physiology at the Microscale: A Critical Status Report on Progress in Toxicology and Pharmacology

Mario Rothbauer et al.

Summary: Organ-on-a-chip technology has emerged as a crucial tool in pharmaceutical and toxicological research over the past decade, with the need for further validation in clinical and pharmaceutical settings.

MICROMACHINES (2021)

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Review Biochemistry & Molecular Biology

Oncoimmunology Meets Organs-on-Chip

Fabrizio Mattei et al.

Summary: The infiltration of immune cells in the tumor microenvironment is an early event that leads to the establishment of dynamic cross-talk. Immune cells sense antigenic cues to mount a specific anti-tumor response while cancer cells emit inhibitory signals to dampen it.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Chemistry, Analytical

Cystic Fibrosis Human Organs-on-a-Chip

Herbert Luke Ogden et al.

Summary: Cystic fibrosis is a genetic disease with major clinical features including respiratory failure, pancreatic insufficiency, and intestinal disease. Differences between animal models and human CF patients present limitations to translational research. Organ-on-a-chip technology offers a promising approach to studying CF and may help overcome some of these limitations.

MICROMACHINES (2021)

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Review Chemistry, Analytical

Physiological and Disease Models of Respiratory System Based on Organ-on-a-Chip Technology

Di Wang et al.

Summary: Microfluidic chip technology provides a platform for better research on respiratory diseases by simulating cell growth space and analyzing specific pathophysiological changes. Organ-on-a-chip enables co-cultivation of multiple cells and control of fluidic conditions, widely used in scientific research.

MICROMACHINES (2021)

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Article Chemistry, Analytical

Breaking the Third Wall: Implementing 3D-Printing Techniques to Expand the Complexity and Abilities of Multi-Organ-on-a-Chip Devices

Yoel Goldstein et al.

Summary: This study introduces two 3D-printing based fabrication methods for a multi-organ-on-a-chip device, aiming to bridge the gap between in vitro models and in vivo conditions. By designing separate compartments for different tissues and integrating individual pairs of inlets and outlets, tissue-specific perfusion rates were achieved, facilitating the generation of tissue-adapted perfusion profiles.

MICROMACHINES (2021)

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Review Engineering, Biomedical

Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

Rick Xing Ze Lu et al.

Summary: Nanoparticles have raised concerns due to potential adverse health effects, necessitating the development of physiologically relevant models for toxicity assessment. Organ-on-a-chip models offer a new avenue for nanotoxicological research by recapitulating in vivo microenvironment and responses.

BIOACTIVE MATERIALS (2021)

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Review Biotechnology & Applied Microbiology

A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems

Luana A. Osorio et al.

Summary: Organ-on-a-Chip (OOAC) systems are engineered microfluidic systems that mimic the physiological environment of specific organs and have the potential to replace animal models. The success of cell cultures within these systems depends on the choice of scaffold, highlighting the critical role of scaffolds in OOAC research.

BIOENGINEERING-BASEL (2021)

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Review Chemistry, Multidisciplinary

Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues

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SMALL (2020)

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Review Engineering, Biomedical

Organ-on-a-chip: recent breakthroughs and future prospects

Qirui Wu et al.

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A Microfluidic Chip Embracing a Nanofiber Scaffold for 3D Cell Culture and Real-Time Monitoring

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NANOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Advances in Hydrogels in Organoids and Organs-on-a-Chip

Haitao Liu et al.

ADVANCED MATERIALS (2019)

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Article Biochemical Research Methods

Brain-on-a-chip: A history of development and future perspective

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BIOMICROFLUIDICS (2019)

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Review Engineering, Biomedical

Organ-on-a-Chip for Cancer and Immune Organs Modeling

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ADVANCED HEALTHCARE MATERIALS (2019)

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Article Engineering, Multidisciplinary

Plasma based surface modification of poly (dimethylsiloxane) electrospun membrane proper for organ-on-a-chip applications

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SCIENTIA IRANICA (2019)

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Review Oncology

Modelling cancer in microfluidic human organs-on-chips

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NATURE REVIEWS CANCER (2019)

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Norhana Jusoh et al.

APL BIOENGINEERING (2019)

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Article Biochemical Research Methods

Personalised organs-on-chips: functional testing for precision medicine

Albert van den Berg et al.

LAB ON A CHIP (2019)

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Article Biochemical Research Methods

Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing

Aaron L. Glieberman et al.

LAB ON A CHIP (2019)

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Review Engineering, Biomedical

Organ-On-A-Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

Samad Ahadian et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Chemistry, Analytical

A novel 3D breast-cancer-on-chip platform for therapeutic evaluation of drug delivery systems

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ANALYTICA CHIMICA ACTA (2018)

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Review Pharmacology & Pharmacy

Organ/body-on-a-chip based on microfluidic technology for drug discovery

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DRUG METABOLISM AND PHARMACOKINETICS (2018)

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Review Nanoscience & Nanotechnology

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Review Gastroenterology & Hepatology

Microfluidic Organ-on-a-Chip Models of Human Intestine

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LAB ON A CHIP (2017)

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LAB ON A CHIP (2017)

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Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

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Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

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LAB ON A CHIP (2016)

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Article Biochemical Research Methods

One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

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In vitro micro-physiological models for translational immunology

Qasem Ramadan et al.

LAB ON A CHIP (2015)

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3D printed microfluidics for biological applications

Chee Meng Benjamin Ho et al.

LAB ON A CHIP (2015)

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Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

Ana Rubina Perestrelo et al.

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Organ-on-a-chip platforms for studying drug delivery systems

Nupura S. Bhise et al.

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Scaling and systems biology for integrating multiple organs-on-a-chip

John P. Wikswo et al.

LAB ON A CHIP (2013)

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Microfabrication of human organs-on-chips

Dongeun Huh et al.

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Microengineered physiological biomimicry: Organs-on-Chips

Dongeun Huh et al.

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