期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.744657
关键词
micelles; lysine; histidine; arginine; basic amino acids; drug delivery
资金
- National Natural Science Foundation of China [51203157]
- Antibiotics Research and Re-evaluation Key Laboratory Foundation of Sichuan Province [ARRLKF15-04]
- Project of Education Department in Sichuan Province [16ZB0421]
This review highlights the common approaches to designing functional polymeric micelles based on basic amino acids and their applications as drug carriers for cancer therapy. Different polypeptide architectures are developed for efficient drug loading and delivery, with polylysine- and polyhistidine-based micelles enabling pH-responsive drug release. Additionally, polyarginine can enhance membrane penetration and gas therapy through generating metabolites of nitric oxide (NO).
Natural amino acids and their derivatives are excellent building blocks of polymers for various biomedical applications owing to the non-toxicity, biocompatibility, and ease of multifunctionalization. In the present review, we summarized the common approaches to designing and constructing functional polymeric micelles based on basic amino acids including lysine, histidine, and arginine and highlighted their applications as drug carriers for cancer therapy. Different polypeptide architectures including linear polypeptides and dendrimers were developed for efficient drug loading and delivery. Besides, polylysine- and polyhistidine-based micelles could enable pH-responsive drug release, and polyarginine can realize enhanced membrane penetration and gas therapy by generating metabolites of nitric oxide (NO). It is worth mentioning that according to the structural or functional characteristics of basic amino acids and their derivatives, key points for designing functional micelles with excellent drug delivery efficiency are importantly elaborated in order to pave the way for exploring micelles based on basic amino acids.
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