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Non-immune Cell Components in the Gastrointestinal Tumor Microenvironment Influencing Tumor Immunotherapy

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出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.729941

关键词

gastrointestinal cancer; tumor microenvironment; exosome; cancer associated fibroblasts; nerves; cytokines; microbiome; tumor immunotherapy

资金

  1. National Natural Science Foundation of China [81874170, 82073261, 32000665, 82060042]
  2. China 111 Project [111-2-12]
  3. Independent Exploration and Innovation Project of Central South University [2020zzts226, 2020zzts769]

向作者/读者索取更多资源

Genetic susceptibility factors, immune microenvironment, and microbial factors interact to contribute to gastrointestinal tumorigenesis. The suppressive immune microenvironment reshaped by tumors directly leads to T-cell depletion in tumor immunotherapy. Soluble factors secreted by tumor or stromal cells collectively shape the suppressive immune environment.
Interactions of genetic susceptibility factors, immune microenvironment, and microbial factors contribute to gastrointestinal tumorigenesis. The suppressive immune microenvironment reshaped by the tumors during gastrointestinal tumorigenesis directly contributes to T-cell depletion in tumor immunotherapy. Soluble factors secreted by tumor cells or stromal cells collectively shape the suppressive immune environment. Here, we reviewed the key factors in the gastrointestinal tumor microenvironment that influence tumor immunotherapy, focusing on the effects of fibroblasts, neuronal cells, soluble cytokines, exosomes, and the microbiome in tumor microenvironment. Research in this field has helped to identify more precise and effective biomarkers and therapeutic targets in the era of tumor immunotherapy.

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