Sirtuin 5 is Dispensable for CD8+ T Cell Effector and Memory Differentiation

CD8(+) T cell effector and memory differentiation is tightly controlled at multiple levels including transcriptional, metabolic, and epigenetic regulation. Sirtuin 5 (SIRT5) is a protein deacetylase mainly located at mitochondria, but it remains unclear whether SIRT5 plays key roles in regulating CD8(+) T cell effector or memory formation. Herein, with adoptive transfer of Sirt5(+/+) or Sirt5(-/-) OT-1 cells and acute Listeria monocytogenes infection model, we demonstrate that SIRT5 deficiency does not affect CD8(+) T cell effector function and that SIRT5 is not required for CD8(+) T cell memory formation. Moreover, the recall response of SIRT5 deficient memory CD8(+) T cells is comparable with Sirt5(+/+) memory CD8(+) T cells. Together, these observations suggest that SIRT5 is dispensable for the effector function and memory differentiation of CD8(+) T cells.

Automated summary

This study demonstrates that SIRT5 is dispensable for the effector function and memory differentiation of CD8(+) T cells.