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Modulation of Phase Separation by RNA: A Glimpse on N6-Methyladenosine Modification

期刊

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.786454

关键词

phase separation; N6-methyladenosine (m 6 A); biomolecular condensate; multivalence; RNA modification; RNA-RNA interaction; RNA-protein interaction

资金

  1. National Natural Science Foundation of China [31972883, 8200015]
  2. Zhejiang Provincial Natural Science Foundation [LY21H160032]
  3. Key research and development program of Zhejiang province [2019C03010]

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Phase separation is driven by RNA as a scaffold for proteins/RNA, particularly through the modification of m(6)A, which changes RNA properties and interactions to modulate phase separation and regulate biological processes.
Phase separation is the driving force behind formation of various biomolecular condensates (BioMCs), which sub-compartmentalize certain cellular components in a membraneless manner to orchestrate numerous biological processes. Many BioMCs are composed of proteins and RNAs. While the features and functions of proteins are well studied, less attention was paid to the other essential component RNAs. Here, we describe how RNA contributes to the biogenesis, dissolution, and properties of BioMCs as a multivalence providing scaffold for proteins/RNA to undergo phase separation. Specifically, we focus on N-6-methyladenosine (m(6)A), the most widely distributed dynamic post-transcriptional modification, which would change the charge, conformation, and RNA-binding protein (RBP) anchoring of modified RNA. m(6)A RNA-modulated phase separation is a new perspective to illustrate m(6)A-mediated various biological processes. We summarize m(6)A main functions as beacon to recruit reader proteins and structural switcher to alter RNA-protein and RNA-RNA interactions to modulate phase separation and regulate the related biological processes.

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