4.7 Review

G Protein-Coupled Receptors in Osteoarthritis: A Novel Perspective on Pathogenesis and Treatment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Orthopedics

Knee osteoarthritis: key treatments and implications for physical therapy

Lucas Ogura Dantas et al.

Summary: Knee osteoarthritis is a chronic progressive disease that poses a significant burden on society and healthcare systems. Recommended treatment strategies include patient education, physical exercise, and weight loss, yet less than 40% of patients receive this intervention. Healthcare providers need to understand the safest and most effective treatment options and outcome measures used in clinical research.

BRAZILIAN JOURNAL OF PHYSICAL THERAPY (2021)

Article Gastroenterology & Hepatology

Targeting G protein-coupled receptors for the treatment of chronic pain in the digestive system

Lena Gottesman-Katz et al.

Summary: Chronic pain is a complex issue with mechanisms that are not fully understood and current treatments being inadequate. Recent studies on G protein-coupled receptors have shed light on potential new approaches for chronic pain management, offering insights into both the structure and function of these receptors. By targeting specific GPCRs and utilizing biased agonists or allosteric modulators, there is promise for developing more effective and targeted therapies for chronic pain in the future.
Article Medicine, General & Internal

Osteoarthritis of the Knee

Leena Sharma

Summary: Knee osteoarthritis is common among older adults and can be treated with a combination of exercise, weight management, training in self-efficacy and pain-coping skills, and medications such as NSAIDs.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Pharmacology & Pharmacy

Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis

Fanhua Wang et al.

Summary: The study identified Gpr84 as the receptor for medium-chain fatty acids in chondrocytes, showing that deficiency of Gpr84 exacerbated cartilage degradation in OA pathogenesis. Activation of Gpr84 enhanced cartilage extracellular matrix generation and protected against OA degeneration, without severe cartilaginous side effects.

PHARMACOLOGICAL RESEARCH (2021)

Article Medicine, Research & Experimental

CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development

Jakub Mlost et al.

Summary: The study evaluated the analgesic potential of two functionally biased CB2 agonists in osteoarthritis treatment, with JWH133 showing superior chronic treatment efficacy compared to GW833972A. JWH133's impact on bone and matrix metabolism helps improve osteoarthritis.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics

Sang-Min Lee et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

Article Multidisciplinary Sciences

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Trinidad Montero-Melendez et al.

NATURE COMMUNICATIONS (2020)

Review Cell Biology

Conformational Basis of G Protein-Coupled Receptor Signaling Versatility

Laura M. Wingler et al.

TRENDS IN CELL BIOLOGY (2020)

Article Chemistry, Medicinal

Activation of GPR40 Suppresses AGE-Induced Reduction of Type II Collagen and Aggrecan in Human SW1353 Chondrocytes

Jiaxiang Gu et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

Article Neurosciences

G-Protein-Coupled Receptor Gpr17 Expression in Two Multiple Sclerosis Remyelination Models

Stella Nyamoya et al.

MOLECULAR NEUROBIOLOGY (2019)

Article Medicine, General & Internal

Cortistatin binds to TNF-α receptors and protects against osteoarthritis

Yunpeng Zhao et al.

EBIOMEDICINE (2019)

Article Biotechnology & Applied Microbiology

GPR39 agonist TC-G 1008 ameliorates IL-1β-induced chondrocyte senescence

Huading Lu et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

Review Respiratory System

Asthma pharmacotherapy: an update on leukotriene treatments

Hoang Kim Tu Trinh et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2019)

Review Endocrinology & Metabolism

Melanocortin Regulation of Inflammation

Wei Wang et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Rheumatology

Intra-articular treatment options for knee osteoarthritis

Ian A. Jones et al.

NATURE REVIEWS RHEUMATOLOGY (2019)

Review Cell & Tissue Engineering

The role of GPCRs in bone diseases and dysfunctions

Jian Luo et al.

BONE RESEARCH (2019)

Review Immunology

Sphingosine 1-phosphate and inflammation

Hideru Obinata et al.

INTERNATIONAL IMMUNOLOGY (2019)

Editorial Material Cell Biology

GPCR signaling: conformational activation of arrestins

Alem W. Kahsai et al.

CELL RESEARCH (2018)

Article Biochemistry & Molecular Biology

A guide to chemokines and their receptors

Catherine E. Hughes et al.

FEBS JOURNAL (2018)

Article Biochemistry & Molecular Biology

Identification of novel GPR17-agonists by structural bioinformatics and signaling activation

Konda Mani Saravanan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Review Pharmacology & Pharmacy

New Insights into Modes of GPCR Activation

Wenjing Wang et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

Review Cardiac & Cardiovascular Systems

G-Protein-Coupled Receptors in Heart Disease

Jialu Wang et al.

CIRCULATION RESEARCH (2018)

Article Medicine, Research & Experimental

GPR17 mediates ischemia-like neuronal injury via microglial activation

Bing Zhao et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

Article Cell Biology

Butyrate Modulates Inflammation in Chondrocytes via GPR43 Receptor

Claudio Pirozzi et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Article Rheumatology

GPR120 is an important inflammatory regulator in the development of osteoarthritis

Yuanfeng Chen et al.

ARTHRITIS RESEARCH & THERAPY (2018)

Article Food Science & Technology

GPR40 mediates potential positive effects of a saturated fatty acid enriched diet on bone

Claire Philippe et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2017)

Article Multidisciplinary Sciences

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84

Zobaer Al Mahmud et al.

SCIENTIFIC REPORTS (2017)

Review Cell Biology

GPCRs: Emerging anti-cancer drug targets

Ainhoa Nieto Gutierrez et al.

CELLULAR SIGNALLING (2017)

Article Rheumatology

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

Carmen Huesa et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

Review Rheumatology

Strategies for the prevention of knee osteoarthritis

Ewa M. Roos et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

Review Chemistry, Medicinal

Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015)

Mei-Kwan Yau et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2016)

Review Immunology

GPR41 and GPR43 in Obesity and inflammation - Protective or Causative?

Zhiwei Ang et al.

FRONTIERS IN IMMUNOLOGY (2016)

Article Medicine, General & Internal

Association of CXCL12 Levels in Synovial Fluid With the Radiographic Severity of Knee Osteoarthritis

Qin Xu et al.

JOURNAL OF INVESTIGATIVE MEDICINE (2016)

Article Biochemistry & Molecular Biology

Inhibition of SDF-1α/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis

Yonghui Dong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Medicine, Research & Experimental

Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis

Laurent-Emmanuel Monfoulet et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2015)

Article Orthopedics

The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice

A. Sophocleous et al.

OSTEOARTHRITIS AND CARTILAGE (2015)

Article Multidisciplinary Sciences

GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing

Huashan Zhao et al.

SCIENTIFIC REPORTS (2015)

Review Rheumatology

G protein-coupled receptors in rheumatology

Elena Neumann et al.

NATURE REVIEWS RHEUMATOLOGY (2014)

Review Pharmacology & Pharmacy

Free fatty acid receptors as therapeutic targets for the treatment of diabetes

Atsuhiko Ichimura et al.

FRONTIERS IN PHARMACOLOGY (2014)

Article Biochemistry & Molecular Biology

Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist

Stephanie Hennen et al.

SCIENCE SIGNALING (2013)

Review Rheumatology

Bradykinin and its role in osteoarthritis

L. De Falco et al.

REUMATISMO (2013)

Review Clinical Neurology

CB2: Therapeutic target-in-waiting

Brady K. Atwood et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2012)

Review Pharmacology & Pharmacy

Physiological roles of the melanocortin MC3 receptor

Benjamin J. Renquist et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases

Ivano Eberini et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2011)

Editorial Material Gastroenterology & Hepatology

Potential beneficial effects of butyrate in intestinal and extrainitestinal diseases

Roberto Berni Canani et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2011)

Article Cell Biology

Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes

Pin-Zhir Chao et al.

JOURNAL OF BIOMEDICAL SCIENCE (2011)

Article Rheumatology

A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22

Hanneke J. M. Kerkhof et al.

ARTHRITIS AND RHEUMATISM (2010)

Review Cell Biology

Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer

Andrea Pia Elste et al.

JOURNAL OF MOLECULAR HISTOLOGY (2010)

Article Biochemistry & Molecular Biology

A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese

Hideyuki Mototani et al.

HUMAN MOLECULAR GENETICS (2008)

Review Cell Biology

Knee osteoarthritis: a role for bradykinin?

S. Meini et al.

INFLAMMATION RESEARCH (2008)

Article Multidisciplinary Sciences

CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature

Zhenhua Miao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Endocrinology & Metabolism

GPR39 signaling is stimulated by zinc ions but not by obestatin

Birgitte Holst et al.

ENDOCRINOLOGY (2007)

Article Biochemistry & Molecular Biology

Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84

Jinghong Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Biotechnology & Applied Microbiology

Osteoarthritis - An untreatable disease?

HA Wieland et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Biochemistry & Molecular Biology

Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradation

YH Hsu et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2004)