4.7 Review

Metabolic Reprogramming and Cell Adhesion in Acute Leukemia Adaptation to the CNS Niche

期刊

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.767510

关键词

central nervous system; CNS; meninges; cell adhesion; metabolism; acute lymphoblastic leukemia; acute myeloid leukemia

向作者/读者索取更多资源

Involvement of the Central Nervous System in acute leukemia is associated with poor prognosis and lower overall survival. Existing therapies pose significant toxicities. Leukemic cells can adapt and survive in the CNS microenvironment. Understanding the mechanisms of leukemic cell survival in the CNS microenvironment is crucial for developing more effective therapies.
Involvement of the Central Nervous System (CNS) in acute leukemia confers poor prognosis and lower overall survival. Existing CNS-directed therapies are associated with a significant risk of short- or long-term toxicities. Leukemic cells can metabolically adapt and survive in the microenvironment of the CNS. The supporting role of the CNS microenvironment in leukemia progression and dissemination has not received sufficient attention. Understanding the mechanism by which leukemic cells survive in the nutrient-poor and oxygen-deprived CNS microenvironment will lead to the development of more specific and less toxic therapies. Here, we review the current literature regarding the roles of metabolic reprogramming in leukemic cell adhesion and survival in the CNS.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据