4.7 Review

Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases

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Article Cell & Tissue Engineering

A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis

Yanyan Jing et al.

Summary: The study elucidates the regulation of ISL1 protein function at the post-translational level by the BMPp38 MAPK signaling axis, highlighting its critical role in cardiac development. Interfering with p38 MAPK signaling leads to ISL1 degradation, impacting cardiomyocyte differentiation and heart morphogenesis and function in zebrafish and mice.

STEM CELL REPORTS (2021)

Article Multidisciplinary Sciences

Amnion signals are essential for mesoderm formation in primates

Ran Yang et al.

Summary: This study reveals that ISL1 controls a gene regulatory network in the amnion of non-human primate embryos, crucial for mesoderm formation. The research highlights the significance of amnion as a signaling center during primate embryogenesis and the potential of in vitro primate models to dissect the genetics of early human embryonic development.

NATURE COMMUNICATIONS (2021)

Review Genetics & Heredity

Pioneer Transcription Factors Initiating Gene Network Changes

Kenneth S. Zaret

ANNUAL REVIEW OF GENETICS, VOL 54, 2020 (2020)

Article Biotechnology & Applied Microbiology

Regenerating the field of cardiovascular cell therapy

Kenneth R. Chien et al.

NATURE BIOTECHNOLOGY (2019)

Article Cardiac & Cardiovascular Systems

A New ISL1 Loss-of-Function Mutation Predisposes to Congenital Double Outlet Right Ventricle

Zhi Wang et al.

INTERNATIONAL HEART JOURNAL (2019)

Article Sport Sciences

Fate Tracing of Isl1 + Cells in Adult Mouse Hearts under Physiological and Exercise Conditions

Yunhe Zhou et al.

INTERNATIONAL JOURNAL OF SPORTS MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

ISL1 loss-of-function mutation contributes to congenital heart defects

Lan Ma et al.

HEART AND VESSELS (2019)

Article Developmental Biology

Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules

Naoyuki Tahara et al.

DEVELOPMENTAL BIOLOGY (2018)

Article Cell & Tissue Engineering

Prospective Isolation of ISL1(+) Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy

Zaniar Ghazizadeh et al.

STEM CELL REPORTS (2018)

Review Biotechnology & Applied Microbiology

Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics

Thomas J. Cahill et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Cell & Tissue Engineering

Transplantation of Isl1+ cardiac progenitor cells in small intestinal submucosa improves infarcted heart function

Lingjun Wang et al.

STEM CELL RESEARCH & THERAPY (2017)

Article Multidisciplinary Sciences

Isl2b regulates anterior second heart field development in zebrafish

Hagen R. Witzel et al.

SCIENTIFIC REPORTS (2017)

Article Cell Biology

Pioneer transcription factors, chromatin dynamics, and cell fate control

Kenneth S. Zaret et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2016)

Article Biochemistry & Molecular Biology

ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells

Yang Wang et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Cell & Tissue Engineering

CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells

Ivette Pacheco-Leyva et al.

STEM CELL REPORTS (2016)

Article Medicine, Research & Experimental

ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction

Oscar Bartulos et al.

JCI INSIGHT (2016)

Article Medicine, Research & Experimental

Transcription factor ISL1 is essential for pacemaker development and function

Xingqun Liang et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Cell & Tissue Engineering

Direct Nkx2-5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity

Tatjana Dorn et al.

STEM CELLS (2015)

Article Genetics & Heredity

Haploinsufficiency of insulin gene enhancer protein 1 (ISL1) is associated with d-transposition of the great arteries

Kazutoyo Osoegawa et al.

MOLECULAR GENETICS & GENOMIC MEDICINE (2014)

Article Cell Biology

Second heart field and the development of the outflow tract in human embryonic heart

Yan-Ping Yang et al.

DEVELOPMENT GROWTH & DIFFERENTIATION (2013)

Article Developmental Biology

Expression of Isl1 during mouse development

Shaowei Zhuang et al.

GENE EXPRESSION PATTERNS (2013)

Article Biochemistry & Molecular Biology

ISL1 Common Variant rs1017 Is Not Associated with Susceptibility to Congenital Heart Disease in a Chinese Population

Lei Xue et al.

GENETIC TESTING AND MOLECULAR BIOMARKERS (2012)

Article Multidisciplinary Sciences

ISL1 Directly Regulates FGF10 Transcription during Human Cardiac Outflow Formation

Christelle Golzio et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Identification and Functional Characterization of Cardiac Pacemaker Cells in Zebrafish

Federico Tessadori et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium

Yusuke Watanabe et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors

Jae-Woo Jang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Neurosciences

Isl1 Is required for multiple aspects of motor neuron development

Xingqun Liang et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2011)

Article Cell & Tissue Engineering

Distinction Between Two Populations of Islet-1-Positive Cells in Hearts of Different Murine Strains

Patricia Khattar et al.

STEM CELLS AND DEVELOPMENT (2011)

Article Multidisciplinary Sciences

Common Variation in ISL1 Confers Genetic Susceptibility for Human Congenital Heart Disease

Kristen N. Stevens et al.

PLOS ONE (2010)

Article Cell & Tissue Engineering

Islet-1 Cells Are Cardiac Progenitors Present During the Entire Lifespan: From the Embryonic Stage to Adulthood

Rami Genead et al.

STEM CELLS AND DEVELOPMENT (2010)

Article Developmental Biology

Identification of regulatory elements in the IsI1 gene locus

Claudia Kappen et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2009)

Article Multidisciplinary Sciences

β-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis

Lizhu Lin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Developmental Biology

Isl1Cre reveals a common Bmp pathway in heart and limb development

L Yang et al.

DEVELOPMENT (2006)

Review Genetics & Heredity

Building the mammalian heart from two sources of myocardial cells

M Buckingham et al.

NATURE REVIEWS GENETICS (2005)

Article Multidisciplinary Sciences

Postnatal isl1+cardioblasts enter fully differentiated cardiomyocyte lineages

KL Laugwitz et al.

NATURE (2005)

Article Developmental Biology

Role of Islet1 in the patterning of murine dentition

TA Mitsiadis et al.

DEVELOPMENT (2003)

Article Neurosciences

A short history of LIM domains (1993-2002): From protein interaction to degradation

S Rétaux et al.

MOLECULAR NEUROBIOLOGY (2002)