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TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis
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AUTOPHAGY (2021)
Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging
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CELL STEM CELL (2021)
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FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
The KDM4B-CCAR1-MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasis
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BONE RESEARCH (2021)
LIF maintains mouse embryonic stem cells pluripotency by modulating TET1 and JMJD2 activity in a JAK2-dependent manner
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STEM CELLS (2021)
Upregulated KDM4B promotes prostate cancer cell proliferation by activating autophagy
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JOURNAL OF CELLULAR PHYSIOLOGY (2020)
Advances in histone demethylase KDM4 as cancer therapeutic targets
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FASEB JOURNAL (2020)
KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation
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JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)
Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells
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STEM CELL REPORTS (2020)
A Novel, Circulating Tumor Cell Enrichment Method Reduces ARv7 False Positivity in Patients with Castration-Resistant Prostate Cancer
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Targeting theKDM4B-AR-c-Mycaxis promotes sensitivity to androgen receptor-targeted therapy in advanced prostate cancer
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JOURNAL OF PATHOLOGY (2020)
Oncometabolites suppress DNA repair by disrupting local chromatin signalling
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NATURE (2020)
Oncometabolites and the response to radiotherapy
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RADIATION ONCOLOGY (2020)
Tudor domain of histone demethylase KDM4B is a reader of H4K20me3
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ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2020)
JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells
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ONCOGENE (2019)
IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2
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BONE (2019)
The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance
Karl Agger et al.
BLOOD (2019)
The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer
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CANCERS (2019)
Chromatin regulators mediate anthracycline sensitivity in breast cancer
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NATURE MEDICINE (2019)
Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation
Lingling Duan et al.
NUCLEIC ACIDS RESEARCH (2019)
Identification of hub genes and key pathways associated with the progression of gynecological cancer
Xi Zhang et al.
ONCOLOGY LETTERS (2019)
Distal-less homeobox 5 promotes the osteo-/dentinogenic differentiation potential of stem cells from apical papilla by activating histone demethylase KDM4B through a positive feedback mechanism
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EXPERIMENTAL CELL RESEARCH (2019)
KDM4B promotes gastric cancer metastasis by regulating miR-125b-mediated activation of Wnt signaling
Jia-Chen Jing et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2019)
Unraveling KDM4 histone demethylase expression and its association with adverse cytogenetic findings in chronic lymphocytic leukemia
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MEDICAL ONCOLOGY (2019)
H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming
Xin Liu et al.
DEVELOPMENT (2018)
Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases
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JOURNAL OF MOLECULAR BIOLOGY (2018)
KDM4B promotes DNA damage response via STAT3 signaling and is a target of CREB in colorectal cancer cells
Wei-Wu Deng et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2018)
KDM4B protects against obesity and metabolic dysfunction
Yingduan Cheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity
May Levin et al.
Oncotarget (2018)
JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities
Changkeun Kang et al.
GENES TO CELLS (2018)
KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer
Wenyu Wang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
Hui-Ju Hsieh et al.
NATURE COMMUNICATIONS (2018)
The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer
C. Wilson et al.
ONCOGENE (2017)
KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage
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NUCLEIC ACIDS RESEARCH (2017)
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
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ACS MEDICINAL CHEMISTRY LETTERS (2017)
Histone H3K9 Demethylase JMJD2B Activates Adipogenesis by Regulating H3K9 Methylation on PPARγ and C/EBPα during Adipogenesis
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PLOS ONE (2017)
Transforming Growth Factor-β-Induced KDM4B Promotes Chondrogenic Differentiation of Human Mesenchymal Stem Cells
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STEM CELLS (2016)
Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma
Hamid Bur et al.
ANTICANCER RESEARCH (2016)
The Prognostic Impact of Jumonji Domain-containing 2B in Patients with Resected Lung Adenocarcinoma
Gouji Toyokawa et al.
ANTICANCER RESEARCH (2016)
Repositioning the Old Fungicide Ciclopirox for New Medical Uses
Tao Shen et al.
CURRENT PHARMACEUTICAL DESIGN (2016)
Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development
Marianne Terndrup Pedersen et al.
EMBO JOURNAL (2016)
Reader domain specificity and lysine demethylase-4 family function
Zhangli Su et al.
NATURE COMMUNICATIONS (2016)
JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression
Fengjuan Han et al.
ONCOTARGET (2016)
KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer
Haijie Li et al.
ONCOTARGET (2016)
KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism
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CELL REPORTS (2016)
Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse
K. Fujiwara et al.
TRANSLATIONAL PSYCHIATRY (2016)
KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer
Shuo Li et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2015)
JMJD2B as a potential diagnostic immunohistochemical marker for hepatocellular carcinoma: A tissue microarray-based study
Jeng-Wei Lu et al.
ACTA HISTOCHEMICA (2015)
The histone demethylase KDM4B interacts with MyoD to regulate myogenic differentiation in C2C12 myoblast cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes
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CHEMISTRY & BIOLOGY (2015)
miR-491-5p functions as a tumor suppressor by targeting JMJD2B in ERα-positive breast cancer
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FEBS LETTERS (2015)
Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression
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JOURNAL OF CELL BIOLOGY (2015)
The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma
Jun Yang et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
Histone demethylase JMJD2B and JMJD2C induce fibroblast growth factor 2: mediated tumorigenesis of osteosarcoma
Xiaojiang Li et al.
MEDICAL ONCOLOGY (2015)
Emodin attenuates radioresistance induced by hypoxia in HepG2 cells via the enhancement of PARP1 cleavage and inhibition of JMJD2B
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ONCOLOGY REPORTS (2015)
KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1
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ONCOTARGET (2015)
The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer
L. Chen et al.
BRITISH JOURNAL OF CANCER (2014)
Distal-less homeobox 2 promotes the osteogenic differentiation potential of stem cells from apical papilla
Binbin Qu et al.
CELL AND TISSUE RESEARCH (2014)
Stimulation of β-catenin and colon cancer cell growth by the KDM4B histone demethylase
William L. Berry et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2014)
Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer
Bei Bei Sun et al.
JOURNAL OF DIGESTIVE DISEASES (2014)
KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor
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JOURNAL OF MEDICINAL CHEMISTRY (2014)
Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity
Partha Pratim Das et al.
MOLECULAR CELL (2014)
The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression
Leah C. Young et al.
BIOCHEMISTRY AND CELL BIOLOGY (2013)
Heat Shock Protein 90 (Hsp90) Selectively Regulates the Stability of KDM4B/JMJD2B Histone Demethylase
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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Functional Analysis of Histone Demethylase Jmjd2b on Lipopolysaccharide-Treated Murine Neural Stem Cells (NSCs)
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NEUROTOXICITY RESEARCH (2013)
KDM4B is a Master Regulator of the Estrogen Receptor Signalling Cascade
Luke Gaughan et al.
NUCLEIC ACIDS RESEARCH (2013)
The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover
Kelly Coffey et al.
NUCLEIC ACIDS RESEARCH (2013)
Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B
Lu Wen et al.
ACTA PHARMACOLOGICA SINICA (2012)
Histone demethylase JMJD2B-mediated cell proliferation regulated by hypoxia and radiation in gastric cancer cell
Joong-Gook Kim et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2012)
HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism
Linna Fu et al.
CARCINOGENESIS (2012)
Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes
L. Guo et al.
CELL DEATH AND DIFFERENTIATION (2012)
Histone Demethylases KDM4B and KDM6B Promote Osteogenic Differentiation of Human MSCs
Ling Ye et al.
CELL STEM CELL (2012)
TSA-Induced JMJD2B Downregulation Is Associated With Cyclin B1-Dependent Survivin Degradation and Apoptosis in LNCap Cells
Shan Zhu et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2012)
Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer
Wenjuan Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
The Testis-Enriched Histone Demethylase, KDM4D, Regulates Methylation of Histone H3 Lysine 9 During Spermatogenesis in the Mouse but Is Dispensable for Fertility
Naoki Iwamori et al.
BIOLOGY OF REPRODUCTION (2011)
JmjN interacts with JmjC to ensure selective proteolysis of Gis1 by the proteasome
Zhenzhen Quan et al.
MICROBIOLOGY-SGM (2011)
Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development
Masahito Kawazu et al.
PLOS ONE (2011)
Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
Lei Shi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Ciclopirox Recent Nonclinical and Clinical Data Relevant to its Use as a Topical Antimycotic Agent
Alessandro Subissi et al.
DRUGS (2010)
Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors
Shohei Hamada et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Dynamic Nuclear Organization of Constitutive Heterochromatin During Fetal Male Germ Cell Development in Mice
Hirotaka Yoshioka et al.
BIOLOGY OF REPRODUCTION (2009)
Alterations of histone modifications by cobalt compounds
Qin Li et al.
CARCINOGENESIS (2009)
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins
Patrick Trojer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
Gregg L. Semenza
SEMINARS IN CANCER BIOLOGY (2009)
The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF
Sophie Beyer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases
Nathan R. Rose et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D
Sook Shin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Lysine-specific demethylase 1 as a potential therapeutic target
Pete Stavropoulos et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2007)
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases
Shigeki Iwase et al.
CELL (2007)
Diversity within the JMJD2 histone demethylase family
Sook Shin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Dynamic regulation of histone lysine methylation by demethylases
Yang Shi et al.
MOLECULAR CELL (2007)
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
Paul A. C. Cloos et al.
NATURE (2006)
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells
Barna D. Fodor et al.
GENES & DEVELOPMENT (2006)
Structural insights into histone demethylation by JMJD2 family members
Zhongzhou Chen et al.
CELL (2006)