期刊
ADDITIVE MANUFACTURING
卷 48, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.addma.2021.102392
关键词
Solvent-cast direct-writing; Bioresorbable stents; Poly-L-lactic acid; Radiopacity; X-Ray imaging
资金
- Spanish Government
- MINECO/FEDER [RTI2018-098075-B-C21]
- Agency for Administration of University and Research Grants (AGAUR) of the Government of Catalonia [2017SGR-1165]
- European Union Regional Development Fund within the framework of the ERDF Operational Program of Catalonia [001-P-001646]
- Generalitat de Catalunya [2019FI-B00627]
The research explores the potential of bioresorbable stents in treating coronary heart disease and introduces a novel printing system for manufacturing stents with good mechanical properties and biocompatibility. The addition of radiopaque agents to polymeric inks enhances the radiopacity of stents.
Bioresorbable stents (BRS) potential in treating coronary heart disease is still to be further developed. Current trends include research with new polymeric materials, the need for thinner struts combined with appropriate mechanical properties, radiopacity and optimized local drug delivery. This work presents a novel solvent-cast direct-write (SC-DW) printing system to manufacture BRS onto a rotating cylinder with poly-L-lactic acid (PLLA) and poly(L-lactic-co-epsilon-caprolactone) (PLCL) inks. Printed stents were characterized in terms of mechanical, thermal and biological properties with human umbilical vein endothelial cells (HUVECs). Expansion assays showed that stents withstood pressures of at least 16 atm and the indirect cytotoxicity test indicated that stents were biocompatible. Polymeric inks were further modified with the addition of 3 radiopaque agents, namely iodine, triiodobenzoic acid (TIBA) and barium sulfate (BaSO4) to render stents radiopaque. Subsequent characterization showed a general increase in strut thickness with respect to control PLLA or PLCL stents, which in turn resulted in higher resistance to compression. Microcomputed tomography was used to assess stents' radiopacity, showing that TIBA and BaSO4-containing stents presented high X-ray attenuation values and maintained their radiopacity after 3 months incubation time.
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