期刊
GUT MICROBES
卷 14, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2021.1997296
关键词
Microbiota; gut motility; bacterial metabolites; computational modeling
资金
- Rosalind Franklin Fellowships
- European Union
- University of Groningen
The human gastrointestinal tract is populated by trillions of microbes that play a significant role in regulating intestinal physiology, including gut motility. Understanding the inter-regulatory mechanisms between the microbiota and bowel function is crucial for addressing gut dysmotility and associated diseases.
The human gastrointestinal tract is home to trillions of microbes. Gut microbial communities have a significant regulatory role in the intestinal physiology, such as gut motility. Microbial effect on gut motility is often evoked by bioactive molecules from various sources, including microbial break down of carbohydrates, fibers or proteins. In turn, gut motility regulates the colonization within the microbial ecosystem. However, the underlying mechanisms of such regulation remain obscure. Deciphering the inter-regulatory mechanisms of the microbiota and bowel function is crucial for the prevention and treatment of gut dysmotility, a comorbidity associated with many diseases. In this review, we present an overview of the current knowledge on the impact of gut microbiota and its products on bowel motility. We discuss the currently available techniques employed to assess the changes in the intestinal motility. Further, we highlight the open challenges, and incorporate biophysical elements of microbes-motility interplay, in an attempt to lay the foundation for describing long-term impacts of microbial metabolite-induced changes in gut motility.
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