期刊
APPLIED MATERIALS TODAY
卷 25, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.apmt.2021.101188
关键词
Microneedle patches; Drug delivery system; Light therapy; Hierarchical nanoparticles; Hair regrowth; Yellow light
资金
- National Natural Science Founda-tion of China [31860263]
- Science Foundation of Jiangxi Provincial Department of Education [20161ACB21002, 20165BCB19002]
- Nanchang University Seed Grant for Biomedicine
The study introduced a collaborative hair growth technology which effectively promoted hair follicle regeneration through the integration of microneedle patches, exosomes of human amniotic mesenchymal stem cells, and hair nanoparticles. This innovative approach showed significant results in animal experiments, with no apparent adverse effects, indicating its potential for broad clinical application.
Inspired by the progress of seed germination (plowing, breeding and lighting), we presented a similar collaborative hair growth technology, which integrated soluble microneedle patches (MNs) with the ex-osomes of human amniotic mesenchymal stem cells (hAMSCs) and hair nanoparticles (HNP). The HNP-decorated microneedle patches (HMNs) could successfully penetrate the cuticle (plowing) and assist in delivering the exosomes of hAMSCs into the dermis to excite hair follicles stem cells (breeding), allow-ing hair follicles to entry anagen from telogen. Meanwhile, our homemade low-color-temperature yellow light (1900 K) also alleviated the inflammation of hair follicles (lighting), thus further promoting hair re-growth. After conducting animal experiments of three kinds of models, our data demonstrated this syn-ergistic strategy could effectively facilitate hair regrowth within 7 days compared with the conventional monotherapy. In vitro and in vivo biocompatibility studies also showed inconspicuous adverse effects or inflammation, elucidating its broad prospect for clinical application. (c) 2021 Elsevier Ltd. All rights reserved.
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