☆ 4.7 Article

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells

SCIENCE IMMUNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

Jin Wei et al.

Summary: Identification of essential host genes for SARS-CoV-2 infection, including ACE2 and Cathepsin L, and the discovery of pro-viral genes and pathways specific to SARS lineage and pan-coronavirus provide potential therapeutic targets and insights into pathogenesis of COVID-19. Small-molecule antagonists of these gene products inhibited SARS-CoV-2 infection across species, highlighting their conserved role in susceptibility to highly pathogenic CoVs.

CELL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Correlates of protection against SARS-CoV-2 in rhesus macaques

Katherine McMahan et al.

Summary: Adoptive transfer of purified IgG from convalescent macaques protects naive macaques against SARS-CoV-2 infection, and cellular immune responses contribute to protection against rechallenge with SARS-CoV-2. The findings suggest that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in macaques, while higher antibody titres are required for treatment of SARS-CoV-2 infection.

NATURE (2021)

添加到收藏夹

Article Microbiology

Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals

Jian Zhang et al.

Summary: COVID-19 is caused by SARS-CoV-2, and the majority of convalescent individuals maintain neutralizing antibodies against SARS-CoV-2. Those who experienced severe COVID-19 had higher levels of neutralizing antibodies, a faster increase in lymphocyte counts, and a higher frequency of CXCR3(+) T-follicular help cells.

NATURE MICROBIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The antigenic anatomy of SARS-CoV-2 receptor binding domain

Wanwisa Dejnirattisai et al.

Summary: Antibodies play a crucial role in immune protection against SARS-CoV-2, with some being used as therapeutics. A study identified 377 human monoclonal antibodies, focusing on 80 that bind the virus spike, and found that most highly inhibitory antibodies can block the virus-receptor interaction. Novel binding modes of potent inhibitory antibodies were discovered, showing potential for prophylactic or therapeutic use in animal models.

CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Daming Zhou et al.

Summary: The race to develop vaccines against SARS-CoV-2 variants, such as B.1.1.7, B.1.351, and P.1, is ongoing as these variants have mutations in the spike protein, potentially leading to immune escape. A structure-function analysis of B.1.351 revealed tighter ACE2 binding and widespread evasion from monoclonal antibody neutralization, particularly driven by the E484K mutation.

CELL (2021)

添加到收藏夹

Article Cell Biology

Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients

Yang Li et al.

Summary: By analyzing the serum IgG response of 1,051 COVID-19 patients, researchers identified linear epitopes of the SARS-CoV-2 Spike protein, revealing two regions rich in linear epitopes and identifying variable peptide responses associated with disease severity. Antibodies obtained from immunizing mice with linear epitopes did not show significant neutralizing activity against the virus, suggesting the importance of understanding humoral responses for vaccine refinement.

CELL REPORTS (2021)

添加到收藏夹

Article Cell Biology

Stabilized coronavirus spike stem elicits a broadly protective antibody

Ching-Lin Hsieh et al.

Summary: This study developed stabilized stem (SS) antigens by removing the S1 subunit from the Middle East respiratory syndrome (MERS)-CoV spike (S) glycoprotein using structure-guided protein engineering. Vaccination with MERS SS elicited cross-reactive b-CoV antibody responses and protected mice against lethal MERS-CoV challenge. The discovery of a panel of cross-reactive monoclonal antibodies, among which IgG22 showed high affinity binding to both MERS-CoV and severe acute respiratory syndrome (SARS)-CoV-2 S proteins, indicates the potential for cross-reactive CoV antibodies.

CELL REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

Markus Hoffmann et al.

Summary: The emerging SARS-CoV-2 variants may exhibit resistance to existing neutralizing antibodies and treatments, which could have significant implications for pandemic containment efforts.

CELL (2021)

添加到收藏夹

Review Immunology

Antigen-dependent multistep differentiation of T-follicular helper cells and its role in SARS-CoV-2 infection and vaccination

Dirk Baumjohann et al.

Summary: Tfh cells are essential for potent humoral immune responses, and their differentiation and memory maintenance are influenced by various factors, including interactions with APCs, costimulatory and coinhibitory pathways, and cytokines. Understanding the differentiation and memory maintenance of Tfh cells is crucial for a deeper understanding of immune responses and vaccine development.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses

Jared Feldman et al.

Summary: Exposure to pathogens triggers adaptive immune responses; understanding the naive B cell repertoire aids in mounting protective responses; naive antibodies can recognize and neutralize SARS-CoV-2.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

Lingshu Wang et al.

Summary: The study identified four receptor binding domain-targeting antibodies with potent neutralizing activity against 23 variants, including two ultrapotent antibodies. Combinations of these antibodies reduced the in vitro generation of escape mutants, showing potential in mitigating resistance development.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Broad betacoronavirus neutralization by a stem helix-specific human antibody

Dora Pinto et al.

Summary: The study identified five monoclonal antibodies from COVID-19 convalescent individuals that cross-react with multiple betacoronavirus spike glycoproteins, with one antibody (S2P6) showing broad neutralization of viruses from three different subgenera. This antibody reduced viral burden in hamsters challenged with SARS-CoV-2 by inhibiting membrane fusion, providing a framework for the design of pan-betacoronavirus vaccines for broad protection.

SCIENCE (2021)

添加到收藏夹

Review Immunology

CD4+T cells that help B cells - a proposal for uniform nomenclature

Stephanie C. Eisenbarth et al.

Summary: Tfh and Tfh-like cells guide B cell differentiation in secondary lymphoid tissues, playing essential roles in humoral immunity. They produce diverse combinations of cytokines and chemokine receptors to promote the generation of antibodies with different properties.

TRENDS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Assembly of a spatial circuit of T-bet-expressing T and B lymphocytes is required for antiviral humoral immunity

Alejandra Mendoza et al.

Summary: This study reveals that during lung influenza infection, T-bet-expressing T and B lymphocytes form a circuit within the lymph nodes that enables coordinated interactions, leading to a strong and coherent humoral immune response tailored for optimal antiviral immunity.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Antibody epitope repertoire analysis enables rapid antigen discovery and multiplex serology

Kathy Kamath et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Immunology

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

Benjamin Israelow et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients

Ya-qi Duan et al.

CURRENT MEDICAL SCIENCE (2020)

添加到收藏夹

Article Biochemical Research Methods

CoV-AbDab: the Coronavirus Antibody Database

Matthew I J Raybould et al.

BIOINFORMATICS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

Naoki Kaneko et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Carolyn Rydyznski Moderbacher et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

Davide F. Robbiani et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Philip J. M. Brouwer et al.

SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structural basis of a shared antibody response to SARS-CoV-2

Meng Yuan et al.

SCIENCE (2020)

添加到收藏夹

Article Biochemical Research Methods

Somatic hypermutation analysis for improved identification of B cell clonal families from next-generation sequencing data

Nima Nouri et al.

PLOS COMPUTATIONAL BIOLOGY (2020)

添加到收藏夹

Article Immunology

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

Matthew C. Woodruff et al.

NATURE IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production

Yuezhou Chen et al.

CELL (2020)

添加到收藏夹

Review Immunology

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

Shane Crotty

IMMUNITY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex

Victoria A. Avanzato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Multidisciplinary Sciences

ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice

Huabin Liang et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Immunology

Cutting Edge: T Cell-Dependent Plasmablasts Form in the Absence of Single Differentiated CD4+ T Cell Subsets

Jessica A. Kotov et al.

JOURNAL OF IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

Liver Is a Generative Site for the B Cell Response to Ehrlichia muris

Nikita Trivedi et al.

IMMUNITY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection

Gang Xin et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Allergy

Follicular helper T cells mediate IgE antibody response to airborne allergens

Takao Kobayashi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

Sustained T follicular helper cell response is essential for control of chronic viral infection

Ute Greczmiel et al.

SCIENCE IMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data

Ang Cui et al.

JOURNAL OF IMMUNOLOGY (2016)

添加到收藏夹

Article Immunology

Protective neutralizing influenza antibody response in the absence of T follicular helper cells

Kosuke Miyauchi et al.

NATURE IMMUNOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

Padmini S. Pillai et al.

SCIENCE (2016)

添加到收藏夹

Article Biochemical Research Methods

Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data

Namita T. Gupta et al.

BIOINFORMATICS (2015)

添加到收藏夹

Article Immunology

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation

Roberto Di Niro et al.

IMMUNITY (2015)

添加到收藏夹

Article Biochemical Research Methods

pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires

Jason A. Vander Heiden et al.

BIOINFORMATICS (2014)

添加到收藏夹

Article Immunology

Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells

John P. Ray et al.

IMMUNITY (2014)

添加到收藏夹

Review Cell Biology

How T follicular helper cells and the germinal centre response change with age

Michelle A. Linterman

IMMUNOLOGY AND CELL BIOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

Xindong Liu et al.

NATURE (2014)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

添加到收藏夹

Article Immunology

Insights into the Role of Bcl6 in Follicular Th Cells Using a New Conditional Mutant Mouse Model

Kristin Hollister et al.

JOURNAL OF IMMUNOLOGY (2013)

添加到收藏夹

Article Immunology

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

Rachael Keating et al.

NATURE IMMUNOLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Human circulating influenza-CD4(+) ICOS1(+)IL-21(+) T cells expand after vaccination, exert helper function, and predict antibody responses

Fabiana Spensieri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

添加到收藏夹

Article Cell Biology

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

Salah-Eddine Bentebibel et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

添加到收藏夹

Article Immunology

Mocels of somatic hypermutation tageting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data

Gur Yaari et al.

FRONTIERS IN IMMUNOLOGY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Quantifying selection in high-throughput Immunoglobulin sequencing data sets

Gur Yaari et al.

NUCLEIC ACIDS RESEARCH (2012)

添加到收藏夹

Article Immunology

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

Sau K. Lee et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

添加到收藏夹

Article Immunology

Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells

Laura M. Fahey et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

添加到收藏夹

Article Virology

Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4+ T Cells Are Important in Control of SARS-CoV Infection

Jun Chen et al.

JOURNAL OF VIROLOGY (2010)

添加到收藏夹

Article Virology

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus

Paul B. McCray et al.

JOURNAL OF VIROLOGY (2007)

添加到收藏夹

Article Immunology

SAP is required for Th cell function and for immunity to influenza

Cris Kamperschroer et al.

JOURNAL OF IMMUNOLOGY (2006)

添加到收藏夹

Article Immunology

CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses

T Junt et al.

JOURNAL OF IMMUNOLOGY (2005)

添加到收藏夹

Article Immunology

CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection

BO Lee et al.

JOURNAL OF IMMUNOLOGY (2005)

添加到收藏夹

Article Immunology

Antigenic conservation and immunogenicity of the HIV coreceptor binding site

JM Decker et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

添加到收藏夹

Article Multidisciplinary Sciences

SAP is required for generating long-term humoral immunity

S Crotty et al.

NATURE (2003)

添加到收藏夹

Article Multidisciplinary Sciences

Evolution of autoantibody responses via somatic hypermutation outside of germinal centers

J William et al.

SCIENCE (2002)

添加到收藏夹

Article Immunology

Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells

H Toyama et al.

IMMUNITY (2002)

添加到收藏夹

Article Immunology

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival

PP Lee et al.

IMMUNITY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.