Structural Analysis of the SARS-CoV-2 Omicron Variant Proteins

Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Multidisciplinary Sciences

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

Jun Zhang et al.

Summary: The Delta variant of SARS-CoV-2 is more efficient at fusing membranes at low levels of cellular receptor ACE2, possibly contributing to its heightened transmissibility. Each variant shows different rearrangement of the antigenic surface of the S protein, but only the changes in the RBD make it a better target for therapeutic antibodies.

SCIENCE (2021)

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Article Infectious Diseases

Novel SARS-CoV-2 variants: the pandemics within the pandemic

Erik Boehm et al.

Summary: Many new variants of SARS-CoV-2 have been identified as variants of concern/interest due to increased transmissibility, severity, immune escape, and reduced vaccine efficacy. These variants often share similar mutations, such as N501Y and E484K, which lead to partial immune escape, decreased vaccine efficacy, and potentially increased severity.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

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Article Multidisciplinary Sciences