期刊
NATURE BIOMEDICAL ENGINEERING
卷 6, 期 1, 页码 32-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41551-021-00807-9
关键词
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资金
- National Key Research and Development Program of China [2019YFA0905603]
- National Natural Science Foundation of China [51833007, 51988102, 51690152, 81874131]
- Wuhan Institute of Biotechnology (Wuhan, P. R. China) [SD2017-202]
It has been demonstrated that modulating the microbiota in tumors can enhance antitumor immune responses and improve cancer patient survival rates. The use of hydrogel-embedded silver nanoparticles and specific exogenous bacteria shows potential in boosting the effectiveness of cancer therapies by influencing the host's immune system through host-microbiota interactions.
Antitumour immune responses to checkpoint blockade can be augmented by modulating the microbiota in the tumour with hydrogel-embedded silver nanoparticles and specific exogenous bacteria, as shown for mice with squamous carcinoma tumours. Because a host's immune system is affected by host-microbiota interactions, means of modulating the microbiota could be leveraged to augment the effectiveness of cancer therapies. Here we report that patients with oral squamous cell carcinoma (OSCC) whose tumours contained higher levels of bacteria of the genus Peptostreptococcus had higher probability of long-term survival. We then show that in mice with murine OSCC tumours injected with oral microbiota from patients with OSCCs, antitumour responses were enhanced by the subcutaneous delivery of an adhesive hydrogel incorporating silver nanoparticles (which inhibited the growth of bacteria competing with Peptostreptococcus) alongside the intratumoural delivery of the bacterium P. anaerobius (which upregulated the levels of Peptostreptococcus). We also show that in mice with subcutaneous or orthotopic murine OSCC tumours, combination therapy with the two components (nanoparticle-incorporating hydrogel and exogenous P. anaerobius) synergized with checkpoint inhibition with programmed death-1. Our findings suggest that biomaterials can be designed to modulate human microbiota to augment antitumour immune responses.
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