A case series of platelet rich plasma in chronic venous ulcers

Introduction: Venous ulcers are the most common type of leg wounds (80%) and the main cause is chronic venous insufficiency. Autologous platelet-rich plasma (PRP) is a potential wound healing treatment due to its great variety of growth factors. The aim of this study was to describe in a case series the results of poor-leukocyte PRP (P-PRP) or saline for the treatment of chronic non-healing ulcers of the lower extremity. Methods: Eight patients were treated according to the topical therapy: saline solution or P-PRP gel. All patients used double compression stocks and were assisted by a vascular practitioner for up to 12 months or until wound healing. The treatment was performed weekly with cleaning of the affected area, macroscopic evaluation (area measurement and photos) and P-PRP or saline application, and closure with Tegaderm (R). Trial Registration: Retrospectively approved by Brazilian Clinical Trials, register number RBR-7zhgb3 (http://www.ensaiosclinicos.gov.br/rg/RBR-7zhgb3/). Results: All patients showed signs of wound healing with a reduction in wound size and ulcer numbers, but more evident with P-PRP application. Conclusions: The results suggested that P-PRP presented a better result when compared to saline solution in the healing process of long clinical course chronic venous ulcers, when associated to compressive stocks and topical care. (C) 2021, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.

Automated summary

This study investigated the use of P-PRP or saline treatment for chronic non-healing ulcers of the lower extremity in a case series. Results showed that all patients exhibited signs of wound healing, with a more significant effect seen with P-PRP application.