期刊
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
卷 51, 期 12, 页码 2546-2555出版社
WILEY
DOI: 10.1111/ijfs.13236
关键词
Anti-adipogenic effect; Camellia kucha; MAPK pathway; theacrine
资金
- State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) from HKSAR
- State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) from CUHK
- NSFC [81403160]
- Traditional Chinese Medicine Bureau of Guangdong Province [20161214]
- Shenzhen Innovation of Science and Technology Commission [ZDSYS2015060509352 72, JCYJ20160429091935720, JCYJ20150403091931191, 201401099]
Camellia kucha, a wild tea plant with potent antioxidant potential, has been consumed as local beverage for a long history. It is featured for the presence of theacrine and low content of caffeine. Interestingly, compared with caffeine showed strong stimulant effect, theacrine showed sedation, hypnoses and promoting memory function. In this study, the anti-adipogenic ability of Kucha tea (KT) and its main components were evaluated in mouse 3T3-L1 cells. The results indicated that KT acted significantly to decrease lipid droplet accumulation. Moreover, KT decreased the expression of major transcription factors of adipogenesis pathway, such as PPAR and C/EBP . KT also decreased the mRNA and protein levels of fatty acid synthase, fatty acid translocase, steroylcoenzyme A desaturase-1, lipoprotein lipase and acetyl-CoA carboxylase-1. Furthermore, KT suppressed the activation of ERK, p38 and JNK.
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