NRD: Nicotiana Resistance Database, a Comprehensive Platform of Stress Tolerance in Nicotiana

Nicotiana is one of the most important economic crops and model plants; however, its growth is affected by various biotic and abiotic stresses. In this study, 27,142 potential resistance genes were identified in six Nicotiana species, belonging to fourteen gene families and transcription factors related to stress resistance. The results indicate that Nicotiana has a potential abundance resistance background to biotic and abiotic stress, and these genes could be used in resistance breeding in the future. Analyzing the genome sequences of 19 pathogens, 5,421,414 Single Nucleotide Polymorphisms and 1958 Simple Sequence Repeats of pathogens have been obtained. The abundance loci show that the biotic pathogens have a high variability and biodiversity. An open-access database, named the Nicotiana Resistance Database (NRD), has been developed as a user-friendly resistance research platform for Nicotiana. The platform provides theoretical and technical support for the resistance research, including the cultivation of resistant varieties, and the genetics and breeding of Nicotiana and relative species.

Automated summary

This study identified a large number of potential resistance genes in six Nicotiana species, indicating the potential abundance of resistance genes in Nicotiana. Additionally, the analysis of pathogen genome sequences revealed high variability and biodiversity among biotic pathogens. To support resistance research, a user-friendly Nicotiana Resistance Database (NRD) was developed.