期刊
FOOD SCIENCE & NUTRITION
卷 9, 期 12, 页码 6746-6761出版社
WILEY
DOI: 10.1002/fsn3.2626
关键词
fatty acid composition; human breast milk; infant formulas; lipid profile; positional distribution
资金
- National Key Research and Development Program of China [2017YFC1601003]
This study investigated the changes in macronutrient content, lipid profile, fatty acid composition, and positional distribution of human breast milk throughout different lactation periods. The results showed significant variations in nutrient compositions as lactation progressed, with differences in fatty acid percentages compared to Western countries' breast milk samples. This may provide valuable data for the development of infant formulas that closely mimic the composition of Chinese breast milk.
Lactational changes in macronutrient content, lipid profile, fatty acid composition, and positional distribution of human breast milk were investigated in this study. A total of 378 milk samples of six different lactation periods, including 0-5, 6-14, 15-30, 31-90, 91-180, and 181-360 days, were collected cross-sectionally from healthy lactating women in Zhejiang, China. As lactation progressed from 0-5 to 15-30 days, the lipid content and the percentages of C10:0, C12:0, C14:0, C18:2n-6, and C18:3n-3 increased significantly, while the protein concentration and the proportions of phospholipids, cholesterols, C16:0, C18:1n-9, C24:1n-9, C20:4n-6, C22:4n-6, C22:5n-3, and C22:6n-3 decreased notably. When lactation was further extended to 181-360 days, the protein content continued to decrease, and the percentages of C12:0 and C14:0 continued to increase, whereas the levels of other tested nutrients remained stable. Although the triacylglycerol positional distributions of some fatty acids underwent significant lactational variations, C14:0, C16:0, C24:1n-9, C22:4n-6, C22:5n-3, and C22:6n-3 were located mainly at the sn-2 position, while C18:1n-9, C18:2n-6, and C18:3n-3 were primarily distributed at the sn-1,3 positions. Compared with human breast milk reported in Western countries, samples in our study demonstrated higher percentages of C18:2n-6, C18:3n-3, C20:4n-6, and C22:6n-3, but lower proportions of C12:0, C14:0, and C18:1n-9. The results from this study indicated a nutritional composition different from that of the Western countries and may provide useful data for the development of infant formulas closer to Chinese breast milk in terms of the fatty acid composition and its specified positional distribution on triglyceride structure.
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