期刊
ANIMALS
卷 12, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/ani12040507
关键词
canine circovirus; non-diarrheic dogs; rectal swabs; Iran
资金
- Bu-Ali Sina University [98-27-2019]
- Italian Ministry of Health
This study reports the detection and characterization of canine circovirus (CaCV) strains from non-diarrheic dogs in Iran. The results show that CaCV is circulating in non-diarrheic dogs in Iran and highlight the need for further epidemiological investigations in Iranian domestic and wild carnivores.
Simple Summary During the last decade, canine circovirus (CaCV) has been repeatedly reported in domestic dogs with and without acute enteritis. Here we report the detection and full genome characterization of CaCV strains from non-diarrheic dogs in Iran. The results showed the circulation of the virus in this country, with Iranian strains segregating from the CaCVs detected in other countries. Canine circovirus (CaCV) is a single-stranded DNA virus that globally circulates in dogs and wild carnivores. Although the pathogenic potential of the virus has not been fully understood yet, CaCV has been suggested to exacerbate the clinical course of other canine viral infections but also to circulate in dogs without clinical signs. In this study, we carried out real-time PCR assays to detect enteric pathogens from 156 canine rectal swabs collected from dogs without enteritis in 3 different regions in Iran. A total of 14 samples tested positive for CaCV and full-length genome sequences were obtained from 6 of the detected strains. Sequence and phylogenetic analyses showed that, despite the distance between the different sample collection sites, all Iranian CaCV strains were closely related and formed a separate clade from extant CaCVs. The present study shows that CaCV is circulating in non-diarrheic dogs in Iran, thus highlighting the need for further epidemiological investigations in Iranian domestic and wild carnivores.
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