Effects of Selective Dry Cow Treatment on Intramammary Infection Risk after Calving, Cure Risk during the Dry Period, and Antibiotic Use at Drying-Off: A Systematic Review and Meta-Analysis of Current Literature (2000-2021)

Simple Summary The vast majority of all antibiotics used in the dairy industry are applied to control mastitis, one of the most important infectious diseases in dairy cows. The aim of this systematic review and meta-analysis is to evaluate the efficacy of selective dry cow treatment vs. blanket dry cow treatment (i.e., antibiotic treatment of all quarters in all cows) on different measures of udder health as well as antibiotic use at drying-off. In this way, it could contribute to minimizing antimicrobial agent usage, which is increasingly criticized based on a growing spread of antimicrobial resistance and its negative consequences for public health. The objectives of this paper were (i) to perform a systematic review of the literature over the last 21 yr and (ii) to evaluate the efficacy of selective dry cow treatment (SDCT) vs. blanket dry cow treatment (BDCT) in dairy cows regarding the risk of intramammary infection (IMI) after calving, new IMI risk after calving, cure risk during the dry period, and a reduction in antibiotic use at drying-off by meta-analysis. The systematic search was carried out using the databases PubMed, CAB Direct, and ScienceDirect. A meta-analytical assessment was performed for each outcome of interest using random-effects models, and the relative risk (RR) for IMI and cure or the pooled proportion for antibiotic use was calculated. The final number of included studies was n = 3 for IMI risk after calving and n = 5 for new IMI risk after calving, cure risk during the dry period, and antibiotic use. The RR levels for IMI (RR, 95% confidence interval [CI]: 1.02, 0.94-1.11; p = 0.592), new IMI (RR, 95% CI: 1.06, 0.94-1.20; p = 0.994), and cure (RR, 95% CI: 1.00, 0.97-1.02; p = 0.661) did not differ significantly between SDCT and BDCT. Substantial heterogeneity was observed between the trials regarding the pooled proportion of antibiotic use within the SDCT groups (I-2 = 97.7%; p < 0.001). This meta-analysis provides evidence that SDCT seems to be an adequate alternative to BDCT regarding udder health with a simultaneous reduction in antibiotic use. Limitations might arise because of the small number of studies included.

Automated summary

The study evaluated the efficacy of selective dry cow treatment compared to blanket dry cow treatment in dairy cows in terms of udder health and antibiotic use, finding no significant difference between the two methods. Selective dry cow treatment seems to be a suitable alternative to reduce antibiotic use while maintaining udder health.