The Unique Symptom Burden of Patients Receiving CAR T-Cell Therapy

Objectives: There is little research on the patient experience of symptom burden from CAR T-cell therapy, and no validated measure specific to the symptoms of CAR T-cell therapy currently exists. The purpose of this study was to identify symptoms experienced and to determine the content domain for a patient-reported outcome (PRO) measuring symptom burden for patients who had received standard of care CAR T-cell therapy for advanced B-cell lymphoid malignancies. Data Sources: Semi-structured qualitative interviews were conducted with a sample of 21 patients who had received CAR T-cell therapy. Content analysis was used to define the symptom burden content domain. Conclusion: Sixty-two percent of patients were interviewed within 3 months of therapy; 81.0% experienced cytokine release syndrome and 28.6% experienced neurotoxicity. Content analysis found 31 symptoms related to disease and treatment. The most common disease-related symptom identified by patients was pain (43%). The most common symptoms identified by patients as related to CAR T-cell therapy included fatigue (tiredness) (62%), lack of appetite (29%), headache (29%), chills or feeling cold (24%), and feeling confused (24%). The qualitative analysis also confirmed that symptoms interfere with daily activities, work, walking, relationships with others, mood, and enjoyment of life. Implications for Nursing Practice: Patients who receive standard CAR T-cell therapy experience numerous symptoms related to disease and CAR T-cell therapy, including symptoms related to the T-cell infusion. Symptoms may result in interference with daily activities, relationships, treatment adherence, and mood. Oncology nurses should be aware of and assess symptom related to CAR T-cell therapy. (c) 2021 Elsevier Inc. All rights reserved.

Automated summary

This study identified common symptoms experienced by patients receiving CAR T-cell therapy, with pain being the most common disease-related symptom and fatigue, lack of appetite, headache, chills or feeling cold, and feeling confused being common symptoms related to CAR T-cell therapy. Symptoms interfere with daily activities, work, relationships, mood, and enjoyment of life. Oncology nurses should be aware of and assess symptoms related to CAR T-cell therapy to provide appropriate care.