Dopamine-Sensing Characteristics and Mechanism by Using N2/O2 Annealing in Pt/Ti/n-Si Structure

Dopamine detection by using N-2/O-2 annealing in a Pt/Ti/n-Si structure is investigated for the first time. To achieve repeatable and stable dopamine detection, a Pt membrane is annealed at elevated temperatures of 500 to 700 degrees C. N-2/O-2 gas ambient is used to optimize the membrane. The Pt membrane with thicknesses from 5 to 2 nm is optimized. Novel Pt/Ti/n-Si Schottky contact in a metal-electrolyte-membrane-silicon (MEMS) structure detects dopamine with a low concentration of 1 pM. The Pt membrane with N-2 ambient annealing shows the lowest concentration of dopamine sensing with a small volume of 10 mu L, acceptable stability, and repeatability. Scan rate-dependent dopamine concentration sensing is also investigated in the two-terminal measurement method. This study is useful for the early diagnosis of Parkinson's disease in the near future.

Automated summary

The study investigates dopamine detection using N-2/O-2 annealing in a Pt/Ti/n-Si structure, achieving stable detection of low concentrations of dopamine through optimization of the Pt membrane and thickness, which is significant for early diagnosis of Parkinson's disease in the future.