期刊
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
卷 14, 期 -, 页码 4715-4721出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DMSO.S339954
关键词
diabetic retinopathy; fibroblast growth factor 19; type 2 diabetes mellitus
资金
- Chonnam National University Hospital Biomedical Research Institute [BCRI20014]
The study revealed a negative association between serum FGF19 level and diabetic retinopathy in patients with T2DM, suggesting a potential predictive value.
Aim: This study aimed to evaluate whether fibroblast growth factor 19 (FGF19) is associated with the risk of diabetic retinopathy in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 357 patients with T2DM were investigated in this cross-sectional study. Logistic regression analysis was performed to assess the association between FGF19 level and diabetic retinopathy. Results: Serum FGF19 level was significantly lower in patients with diabetic retinopathy in those without diabetic retinopathy. The multivariable analysis revealed a significant association between serum FGF19 level and diabetic retinopathy (odds ratio for every 1 standard deviation increase in logarithmic value = 0.69, 95% confidence interval 0.51-0.94, p = 0.019). Conclusion: Serum FGF19 level was negatively associated with diabetic retinopathy in patients with T2DM.
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