期刊
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
卷 13, 期 12, 页码 2013-2028出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4251/wjgo.v13.i12.2013
关键词
Colorectal cancer; Macrophages; Inflammatory transformation; Tumor microenvironment
资金
- National Nature Science Foundation of China [81874206]
- Shanghai Rising-Star Program [20QA1409300]
- Program for Young Eastern Scholar at Shanghai Institutions of Higher Learning [QD2019034]
Studies have shown that macrophages play a crucial role in the development of colorectal cancer, and the intestinal and hypoxic environments can also affect their function. Targeting macrophages may be a potential therapeutic strategy for CRC.
Colorectal cancer (CRC) is one of the most common and fatal cancers worldwide, and it is also a typical inflammatory cancer. The function of macrophages is very important in the tissue immune microenvironment during inflammatory and carcinogenic transformation. Here, we evaluated the function and mechanism of macrophages in intestinal physiology and in different pathological stages. Furthermore, the role of macrophages in the immune microenvironment of CRC and the influence of the intestinal population and hypoxic environment on macrophage function are summarized. In addition, in the era of tumor immunotherapy, CRC currently has a limited response rate to immune checkpoint inhibitors, and we summarize potential therapeutic strategies for targeting tumor-associated macrophages.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据