Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections

Among patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased as a function of the day 2 area under the curve (AUC), even for daily AUCs within the recommended therapeutic range (400-600). Further data are needed to determine if daily AUCs <400 can be maintained without compromising efficacy.

Automated summary

In patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased with higher day 2 area under the curve (AUC), even when daily AUCs were within the recommended therapeutic range (400-600). Further data is needed to assess if daily AUCs <400 can be maintained without compromising efficacy.