期刊
OPEN FORUM INFECTIOUS DISEASES
卷 9, 期 4, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofac071
关键词
AIDS; hemophagocytosis; HIV; lymphohistiocytosis
This study provides a detailed review of cases of hemophagocytic lymphohistiocytosis (HLH) in HIV patients published between January 2005 and April 2021. The results show specific characteristics and challenges in the diagnosis and treatment of HLH in HIV patients, as well as significant heterogeneity in the treatment regimens used.
We provide an elaborate review of cases published between January 2005 and April 2021 on hemophagocytic lymphohistiocytosis (HLH) in HIV patients. Seventy articles describing 81 adult patients (age >= 19 years) were included. The median age was 40 years, and 78% were males. Only 65% were known to have HIV before presentation. CD4 count was >= 200 cells/mm(3) in 23%, and HIV viral load was <200 copies/mL in 41%. The lack of meticulous reporting of >= 5 of 8 criteria for HLH diagnosis was evident in a third of cases. At least 1 infectious agent-other than HIV-was believed to trigger HLH in 78% of patients. The most common were Epstein-Barr virus (26%), human herpesvirus 8 (21%), and Histoplasma capsulatum (17%). Sixty percent survived. Among those, 93% received treatment for identified secondary trigger(s), while 51% received HLH-directed therapy. There was significant heterogeneity in the treatment regimens used for HLH.
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