期刊
NPJ GENOMIC MEDICINE
卷 6, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41525-021-00253-1
关键词
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资金
- NIH [K23 GM100288-01A1, K08 HG011505]
- Bucksbaum Institute Associate Faculty Scholar Pilot Grant
- William F. O'Connor Foundation
- University of Chicago Pritzker Summer Research Program (NIH) [2T35D062719-26]
- University of Chicago Comprehensive Cancer Center
Black patients have less confidence in personalized treatment decisions made by their providers and overwhelmingly want their genetic information to play a larger role in clinical care. White patients are more likely to discuss the impact of personal/genetic makeup on medication response with providers, while Black patients initiate these discussions much less frequently. Opportunities exist for enhanced communication with underrepresented patients to ensure equitable benefits from pharmacogenomically guided medication treatment.
Within an institutional pharmacogenomics implementation program, we surveyed 463 outpatients completing preemptive pharmacogenomic testing whose genetic results were available to providers for guiding medication treatment. We compared views and experiences from self-reported White and Black patients, including education level as a covariate across analyses. Black patients were less confident about whether their providers made personalized treatment decisions, and overwhelmingly wanted a greater role for their genetic information in clinical care. Both groups similarly reported that providers asked their opinions regarding medication changes, but White patients were more likely (59% vs. 49%, P = 0.005) to discuss the impact of personal/genetic makeup on medication response with providers, and Black patients reported initiating such discussions much less frequently (4% vs. 15%, P = 0.037). Opportunities exist for enhanced communication with underrepresented patients around personalized care. Tailored communication strategies and development of support tools employed in diverse healthcare settings may facilitate pharmacogenomically guided medication treatment that equitably benefits minority patient populations.
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