期刊
DIABETES & METABOLISM JOURNAL
卷 45, 期 5, 页码 675-683出版社
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2020.0107
关键词
Diabetes mellitus; type 2; Drug therapy; combination; Hypoglycemic agents; Injections; Insulin
资金
- Young-Honam Endocrinology and Metabolism Association
- Pusan National University Hospital
The quadruple oral hypoglycemic agent regimen has shown therapeutic efficacy in type 2 diabetes mellitus patients who cannot use insulin or reject injectable therapy. This treatment significantly reduces HbA1c levels, improves lipid profiles and liver enzyme levels, without causing significant safety issues.
Background: Only few studies have shown the efficacy and safety of glucose-control strategies using the quadruple drug combi-nation. Therefore, the aim of the present study was to investigate the usefulness of the quadruple combination therapy with oral hypoglycemic agents (OHAs) in patients with uncontrolled type 2 diabetes mellitus (T2DM). Methods: From March 2014 to December 2018, data of patients with T2DM, who were treated with quadruple hypoglycemic medications for over 12 months in 11 hospitals in South Korea, were reviewed retrospectively. We compared glycosylated hemo-globin (HbA1c) levels before and 12 months after quadruple treatment with OHAs. The safety, maintenance rate, and therapeutic patterns after failure of the quadruple therapy were also evaluated. Results: In total, 357 patients were enrolled for quadruple OHA therapy, and the baseline HbA1c level was 9.0%+/- 1.3% (74.9 +/- 14.1 mmol/mol). After 12 months, 270 patients (75.6%) adhered to the quadruple therapy and HbA1c was significantly reduced from 8.9%+/- 1.2% to 7.8% +/- 1.3% (mean change, -1.1% +/- 1.2%; P< 0.001). The number of patients with HbA1c <7% increased sig-nificantly from 5 to 68 (P< 0.005). In addition, lipid profiles and liver enzyme levels were also improved whereas no changes in body weight. There was no significant safety issue in patients treated with quadruple OHA therapy. Conclusion: This study shows the therapeutic efficacy of the quadruple OHA regimen T2DM and demonstrates that it can be an option for the management of T2DM patients who cannot use insulin or reject injectable therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据