Nanotechnology Applications of Flavonoids for Viral Diseases

Review Food Science & Technology

Effect of Thermal Processing on Key Phytochemical Compounds in Green Leafy Vegetables: A Review

Nandya Putriani et al.

Summary: Green leafy vegetables are rich in phytochemicals, and processing can affect the retention of these compounds. Proper processing is important for maximizing the retention of phytochemicals and promoting health.

FOOD REVIEWS INTERNATIONAL (2022)

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Article Biochemistry & Molecular Biology

In-silicoscreening of plant-derived antivirals against main protease, 3CLproand endoribonuclease, NSP15 proteins of SARS-CoV-2

Aniket Sharma et al.

Summary: The outbreak of Novel Coronavirus or SARS-CoV-2 has led to a global pandemic. This study used an in-silico approach to search for potential anti-viral plant-derived compounds as inhibitors against SARS-CoV-2 replication proteins. The results suggest that certain compounds show potential as inhibitors of the virus. However, further in-vitro and pre-clinical experiments are needed to validate their effectiveness.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

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Article Plant Sciences

Flavonoids are promising safe therapy against COVID-19

Moza Mohamed Alzaabi et al.

Summary: Flavonoids have shown potential inhibitory activity against SARS-CoV-2 and significant immunomodulatory effects, making them a promising option for protection against COVID-19. These compounds may reduce viral activity by targeting essential viral proteins involved in virus entry and replication, while also mitigating inflammatory responses and promoting lipid metabolism in COVID-19 cases.

PHYTOCHEMISTRY REVIEWS (2022)

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Article Biochemistry & Molecular Biology

An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study

Sourav Das et al.

Summary: This study used a blind molecular docking approach to identify potential inhibitors of the SARS-COV-2 main protease, with rutin showing the highest inhibitor efficiency. All studied molecules were able to bind to the active site of the main protease and were surrounded by other active site residues. Further wet-lab experimentation and clinical trials are needed for validation.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Article Biochemistry & Molecular Biology

Natural products may interfere with SARS-CoV-2 attachment to the host cell

Abdo A. Elfiky

Summary: The study tested natural product compounds against the HSPA5 substrate-binding domain beta (SBD beta), the recognition site for the SARS-CoV-2 spike, showing high to moderate binding affinity for phytoestrogens and estrogens which may interfere with SARS-CoV-2 attachment to stressed cells, potentially serving as anti-COVID-19 agents for high-risk individuals such as elders, cancer patients, and front-line medical staff.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Article Biochemistry & Molecular Biology

A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2

Rajib Islam et al.

Summary: The study identified potential inhibitors against SARS-CoV-2 main protease from 40 antiviral phytochemicals via molecular docking and molecular dynamics simulations. A QSAR model was established to predict favorable binding energy, and the selected candidates were found to be safer inhibitors through ADMET analysis. The computational and statistical analysis supported the potential of these phytochemicals as antiviral agents against SARS-CoV-2.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Article Biochemistry & Molecular Biology

Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: anin silicostudy for drug development

Preeti Pandey et al.

Summary: This study investigated the interaction of 10 potential naturally occurring compounds with the SARS-CoV-2 spike protein, indicating their potential to disrupt the binding of the hACE2-S complex. Molecular docking studies and molecular dynamics simulation suggested that flavonoids and non-flavonoids may serve as anti-SARS-CoV-2 agents with drug-likeness properties.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Article Biochemistry & Molecular Biology

Natural derivatives with dual binding potential against SARS-CoV-2 main protease and human ACE2 possess low oral bioavailability: a brief computational analysis

Priyanka Sharma et al.

Summary: The world is in the midst of a health crisis due to COVID-19, prompting the search for a drug candidate with significant clinical benefits and minimal side effects. Computational screening of molecules that can inhibit SARS-CoV-2 at different stages of its infectious cycle is being explored as an alternative approach.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Article Biochemistry & Molecular Biology

Evaluation of green tea polyphenols as novel corona virus (SARS CoV-2) main protease (Mpro) inhibitors - anin silicodocking and molecular dynamics simulation study

Rajesh Ghosh et al.

Summary: The study selected eight polyphenols from green tea, among which three were identified as potential inhibitors against SARS CoV-2 Mpro, showing promise as drug candidates for COVID-19 treatment.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Review Medicine, General & Internal

SARS-CoV-2 and the pandemic of COVID-19

Md Tanveer Adil et al.

Summary: SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic with high mortality rates. Treatment is primarily supportive, and preventive strategies focus on reducing transmission through contact tracing and hygiene practices.

POSTGRADUATE MEDICAL JOURNAL (2021)

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Article Chemistry, Medicinal

Carica papaya Leaf Extract Silver Synthesized Nanoparticles Inhibit Dengue Type 2 Viral Replication In Vitro

Antonia Windkouni Bere et al.

Summary: The study found that Carica papaya leaf extract silver synthesized nanoparticles have a potential anti-dengue effect, with a high IC50 value, and identified the best ligand through molecular docking studies.

PHARMACEUTICALS (2021)

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Review Nutrition & Dietetics

Food Containing Bioactive Flavonoids and Other Phenolic or Sulfur Phytochemicals With Antiviral Effect: Can We Design a Promising Diet Against COVID-19?

Martina Ghidoli et al.

Summary: Despite efforts focused on biotechnological tools during the global pandemic, satisfactory anti-COVID-19 methods have yet to be discovered. The potential of diet, specifically plant-derived secondary metabolites like flavonoids, which possess antiviral and health beneficial properties, is being considered as a way to prevent or alleviate COVID-19.

FRONTIERS IN NUTRITION (2021)

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Article Pharmacology & Pharmacy

The therapeutic effects of naringenin on bronchial pneumonia in children

Wenjing Yao et al.

Summary: Naringenin shows potential as a treatment for bronchial pneumonia in children due to its anti-inflammatory and antimicrobial activities, improving health conditions of patients.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2021)

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Article Biology

Computational selection of flavonoid compounds as inhibitors against SARS-CoV-2 main protease, RNA-dependent RNA polymerase and spike proteins: A molecular docking study

Marimuthu Ragavan Rameshkumar et al.

Summary: This study analyzed the inhibitory potential of flavonoid compounds against important protein targets of SARS-CoV-2 using computational approaches. Virtual screening and docking were conducted, leading to the identification of top 10 lead compounds against main protease, RNA-dependent RNA polymerase, and spike proteins. The study identified potent inhibitors with high docking scores and non-carcinogenic and non-mutagenic properties for further research against SARS-CoV-2.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Pharmacology & Pharmacy

Recent Advancement in Nanotechnology-Based Drug Delivery System Against Viral Infections

Deepak Pradhan et al.

Summary: The exponential rise in viral infections has led to a global health crisis, with the development of a concrete therapeutic regimen proving challenging due to factors such as biomimetic architecture and inappropriate physicochemical parameters. Nanotechnology-based drug delivery offers a promising approach to achieve optimal drug concentration at target sites, with nanoparticle characteristics influencing factors such as target-specific drug delivery, cellular uptake, and cytotoxicity.

AAPS PHARMSCITECH (2021)

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Review Immunology

COVID-19 vaccine: where are we now and where should we go?

Saman Soleimanpour et al.

Summary: The SARS-CoV-2 has caused a global pandemic with the potentially fatal disease, COVID-19, leading to the urgent need for effective vaccines and drugs. Research on COVID-19 vaccine candidates is ongoing, with challenges including finding virulence ability of the virus, suitable experimental models, immune-response study, and designing clinical trials.

EXPERT REVIEW OF VACCINES (2021)

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Review Biochemistry & Molecular Biology

Antiviral Activity of Jamaican Medicinal Plants and Isolated Bioactive Compounds

Henry Lowe et al.

Summary: Plants have been historically significant in medicine since the beginning of civilization. Many countries rely on plants and herbs to treat diseases, with over 65% of the world population solely using botanical preparations as medicine, according to the World Health Organization. Plant-derived medicines are more accessible, affordable, and safer compared to synthetic drugs.

MOLECULES (2021)

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Letter Chemistry, Medicinal

In silico and in vitro evaluation of kaempferol as a potential inhibitor of the SARS-CoV-2 main protease (3CLpro)

Abbas Khan et al.

PHYTOTHERAPY RESEARCH (2021)

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Article Virology

Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188

Gordon J. Lockbaum et al.

Summary: Viral proteases are crucial enzymes for the maturation of human pathogenic viruses, and ML188, a non-covalent inhibitor, shows more potency against SARS-CoV-2 M-pro. These non-covalent inhibitors play a critical role in the design of DAAs for treating COVID-19.

VIRUSES-BASEL (2021)

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Article Physiology

Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019

Francesco Moccia et al.

Summary: Emerging evidence suggests a life-threatening link between SARS-CoV-2 and the cardiovascular system, with COVID-19 severity and fatality rates increasing in patients with pre-existing cardiovascular complications. Pharmacological inhibition of TPCs may prevent viral entry into host cells, making them a potential target for treating cardiovascular complications in COVID-19 patients.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Infectious Diseases

Infection pattern, case fatality rate and spread of Lassa virus in Nigeria

Clement Ameh Yaro et al.

Summary: The study found an annual increase in LASV infections in Nigeria, with over 60% of cases reported in Edo and Ondo states. The need for integrated control strategies including vector control, health education, and early diagnosis was highlighted to combat the disease.

BMC INFECTIOUS DISEASES (2021)

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Review Biochemistry & Molecular Biology

Exploitation of polyphenols and proteins using nanoencapsulation for anti-viral and brain boosting properties-Evoking a synergistic strategy to combat COVID-19 pandemic

Nairah Noor et al.

Summary: The world is facing the threat of the COVID pandemic, leading to mental stress, while nanoencapsulation of certain brain boosting polyphenols may offer a new approach to combat the disease.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Trends and strategies to combat viral infections: A review on FDA approved antiviral drugs

Dharma Rao Tompa et al.

Summary: Infections caused by microscopic viruses can lead to chronic illnesses like HIV/AIDS, flu, etc. Developing new and superior antiviral drugs is crucial, but the drugs can be toxic to human cells and viruses can develop resistance. Combination drugs targeting viral replication are common, but innovative strategies are needed to combat emerging viruses like Ebola and coronaviruses.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Multidisciplinary Sciences

In vitro study of Hesperetin and Hesperidin as inhibitors of zika and chikungunya virus proteases

Raphael J. Eberle et al.

Summary: Two flavonoids derived from citrus plants show inhibitory potential against the virus proteases of CHIKV and ZIKV co-infections, with low cytotoxicity. Their potential as lead compounds for developing potent inhibitors against these viruses is highlighted.

PLOS ONE (2021)

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Editorial Material Virology

Special Issue Emerging Viruses 2020: Surveillance, Prevention, Evolution and Control

Fabricio Souza Campos et al.

VIRUSES-BASEL (2021)

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Article Virology

Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa

Ongeziwe Taku et al.

Summary: South African women in the Eastern Cape province have a high prevalence of HPV infection in CIN, especially in HIV-positive individuals. The study found a higher rate of multiple HPV types in HIV-positive women and identified common HPV genotypes in CIN2 and CIN3 cases. The nonavalent HPV vaccine could offer some benefits in preventing CIN2 and CIN3 in both HIV-negative and HIV-positive women, although complete protection may not be guaranteed.

VIRUSES-BASEL (2021)

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Review Nutrition & Dietetics

Phytonutrient and Nutraceutical Action against COVID-19: Current Review of Characteristics and Benefits

Nitida Pastor et al.

Summary: The trend of using phytonutrients and nutraceuticals to impact immune health has increased recently, as these substances may have immunomodulating effects that can be used for prevention and treatment of viral diseases, including COVID-19. Research has identified certain flavonoids as potential adjuvant therapeutic agents against viral infections, particularly COVID-19.

NUTRIENTS (2021)

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Review Immunology

COVID-19 Vaccine Hesitancy Worldwide: A Concise Systematic Review of Vaccine Acceptance Rates

Malik Sallam

Summary: COVID-19 vaccine acceptance rates are generally high worldwide, but low rates are reported in the Middle East, Russia, Africa, and certain European countries. This could pose a significant challenge in global efforts to control the pandemic. More studies are recommended to address COVID-19 vaccine hesitancy in different regions.

VACCINES (2021)

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Article Chemistry, Medicinal

Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro

Yingzhuan Zhan et al.

Summary: The cases and deaths of COVID-19 are still rising globally, with no effective treatment available yet, but vaccines and antiviral drugs are in development. Seabuckthorn and its flavonoid compounds quercetin and isorhamnetin have shown potential in preventing viral infections by targeting ACE2, which is the receptor for SARS-CoV-2 infection.

DRUG DEVELOPMENT RESEARCH (2021)

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Article Health Care Sciences & Services

COVID-19 vaccine challenges: What have we learned so far and what remains to be done?

Rebecca Forman et al.

Summary: The development and distribution of a safe and effective SARS-CoV-2 (COVID-19) vaccine has attracted global interest. Despite emergency use authorization for several vaccine candidates within a year of the pandemic, there are still significant policy challenges that require a collaborative global response.

HEALTH POLICY (2021)

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Article Nanoscience & Nanotechnology

Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats

Asmaa M. Shehata et al.

Summary: The study showed that exposure to Ag-NPs had adverse effects on the male reproductive system, affecting sperm motility, morphology, and concentration, inducing oxidative stress and lipid peroxidation in testicular tissue, and decreasing serum hormone levels. However, coadministration of Zn-NPs ameliorated most of the toxic effects of Ag-NPs through their antioxidative capacity.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Chemistry, Multidisciplinary

Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

M. Ghezzi et al.

Summary: Polymeric micelles, innovative aggregation colloids formed by self-assembling of amphiphilic polymers in solution, offer advantages in drug administration but also face challenges such as lower stability and complex characterization. Understanding their interaction with the biological environment is crucial, and a combination of different characterization techniques can provide a deeper insight into their in vivo behavior.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Biotechnology & Applied Microbiology

The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection

Lisa Henss et al.

Summary: EGCG showed antiviral activity against SARS-CoV-2 by blocking virus entry and inhibiting infections, suggesting it could be a lead structure for developing more effective anti-COVID-19 drugs.

JOURNAL OF GENERAL VIROLOGY (2021)

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Article Biochemistry & Molecular Biology

The Inhibitory Effects of Plant Derivate Polyphenols on the Main Protease of SARS Coronavirus 2 and Their Structure-Activity Relationship

Thi Thanh Hanh Nguyen et al.

Summary: The study showed that active M-pro was obtained through overexpression in E. coli BL21 (DE3). The optimal pH and temperature of M-pro were found to be 7.5 and 37 degrees Celsius, respectively, with a K-m value of 16μM. Inhibitory effects on M-pro were observed with black garlic extract and various polyphenols, with tannic acid in combination with puerarin, daidzein, and/or myricetin enhancing the inhibitory effects.

MOLECULES (2021)

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Review Chemistry, Medicinal

Rutin: A Potential Antiviral for Repurposing as a SARS-CoV-2 Main Protease (Mpro) Inhibitor

Pawan K. Agrawal et al.

Summary: Rutin has been identified as a potential hit with prominent binding affinity to SARS-CoV-2, and its presence in traditional antiviral medicines in China supports its promise as a repurposed bioactive secondary metabolite against the virus.

NATURAL PRODUCT COMMUNICATIONS (2021)

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Editorial Material Biochemistry & Molecular Biology

The need for a new strategy for Ebola vaccination

Daniel G. Bausch

Summary: The outbreaks of Ebola virus disease in the Democratic Republic of the Congo and Republic of Guinea, amidst the COVID-19 pandemic, highlight the necessity for a revision in vaccination strategies in the area.

NATURE MEDICINE (2021)

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Review Chemistry, Medicinal

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2

Abhishek Gour et al.

Summary: The emergence of SARS-CoV-2 and COVID-19 has caused worldwide panic since December 2019, prompting the search for novel therapeutics. Plant natural products, especially flavonoids, have shown potential in immunomodulation to combat the cytokine release storm during COVID-19 infection. Research on these natural products may lead to the development of effective and safe management strategies for SARS-CoV-2.

PHYTOTHERAPY RESEARCH (2021)

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Article Chemistry, Medicinal

Plant-derived chemicals as potential inhibitors of SARS-CoV-2 main protease (6LU7), a virtual screening study

Mohsen Sisakht et al.

Summary: A dataset of plant-based natural compounds was screened for antiviral activity against SARS-CoV-2 main protease, with several phytochemicals identified as potential inhibitors that could be used in the fight against COVID-19.

PHYTOTHERAPY RESEARCH (2021)

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Editorial Material Multidisciplinary Sciences

Herd immunity is an important-and often misunderstood-public health phenomenon

Amy McDermott

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Pharmacology & Pharmacy

Curcumin as a Potential Treatment for COVID-19

Brune A. C. Rattis et al.

Summary: COVID-19 is a highly infectious disease with high mortality rates, posing challenges in patient management. Curcumin, a natural compound with multiple mechanisms of action, is considered beneficial in the treatment of COVID-19.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Infectious Diseases

Human coronaviruses and therapeutic drug discovery

Lan-Gui Song et al.

Summary: This review provides an overview of drug development against HCoVs, particularly SARS-CoV-2, highlighting advancements in antiviral drugs, drugs targeting the host's immune response, and plant-derived drugs. Clinical trials targeting SARS-CoV-2 are also discussed. Efforts are being made to study the efficacy and safety of potential drugs to better control the COVID-19 pandemic.

INFECTIOUS DISEASES OF POVERTY (2021)

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Article Chemistry, Multidisciplinary

Antiviral Activity of Silver, Copper Oxide and Zinc Oxide Nanoparticle Coatings against SARS-CoV-2

Padryk Merkl et al.

Summary: Nanosilver coatings exhibit the strongest antiviral activity against SARS-CoV-2, followed by copper oxide, while zinc oxide shows minimal reduction in virus infectivity. Therefore, nanosilver and copper oxide have the potential as antiviral coatings on solid surfaces and filter media.

NANOMATERIALS (2021)

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Review Cell Biology

The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection

Antonella D'Amore et al.

Summary: Naringenin, a flavonoid found in citrus fruits and tomatoes, has been identified as a blocker of the two-pore channel (TPC) family, which has a role in various diseases. It has been shown to impair new blood vessel formation in solid tumors by specifically targeting TPC activity. The inhibition of TPC by naringenin could be an effective pharmacological strategy in combating the COVID-19 pandemic.

CELLS (2021)

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Article Biochemistry & Molecular Biology

Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs

Bruno Rizzuti et al.

Summary: The study demonstrates that the natural flavonoid rutin, a glycosylated conjugate of quercetin, can effectively inhibit the SARS-CoV-2 main protease 3CLpro. Despite its lower bioavailability, rutin maintains high potency and binding efficiency to the active site of 3CLpro. This suggests potential implications for the design of quercetin analogs and other antivirals targeting the catalytic site of SARS-CoV-2 3CLpro.

BIOMEDICINES (2021)

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Article Health Care Sciences & Services

Differences among COVID-19, Bronchopneumonia and Atypical Pneumonia in Chest High Resolution Computed Tomography Assessed by Artificial Intelligence Technology

Robert Chrzan et al.

Summary: This study compared automatic assessment of HRCT chest images by artificial intelligence in patients with pneumonia subgroups: COVID-19, bronchopneumonia, and atypical pneumonia. Significant differences were found in inflammation volume and ground glass percentage among the subgroups. However, there was partial overlap between COVID-19 pneumonia and atypical pneumonia, potentially limiting the usefulness of automatic analysis in differentiating the etiology.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Veterinary Sciences

The antiviral activity of kaempferol against pseudorabies virus in mice

Lixia Li et al.

Summary: The results of this study indicate that kaempferol shows anti-Pseudorabies virus activity in mice, improving survival rates, inhibiting virus replication, alleviating pathogenic changes in organs, and affecting viral gene transcription.

BMC VETERINARY RESEARCH (2021)

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Article Chemistry, Physical

In silico detection of inhibitor potential of Passiflora compounds against SARS-Cov-2(Covid-19) main protease by using molecular docking and dynamic analyses

Serap Yalcin et al.

Summary: The study investigated the drug potential of Passiflora compounds for COVID-19 main protease using molecular docking, which showed promising results in terms of therapeutic potential.

JOURNAL OF MOLECULAR STRUCTURE (2021)

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Review Biochemistry & Molecular Biology

Antiviral Effects of Green Tea EGCG and Its Potential Application against COVID-19

Ying-Qi Wang et al.

Summary: EGCG, the most abundant component of catechins in tea, plays an antiviral role by inhibiting virus invasiveness and gene replication. Its effects on various viruses, including DNA virus, RNA virus, coronavirus, enterovirus, and arbovirus, were reviewed in this paper. Additionally, the antiviral effects of its epi-isomer counterpart GCG were also discussed.

MOLECULES (2021)

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Editorial Material Biochemistry & Molecular Biology

Understanding COVID-19 vaccine hesitancy

Shingai Machingaidze et al.

Summary: The new study reveals the complexities of COVID-19 vaccine hesitancy and acceptance in low-, middle-, and high-income countries.

NATURE MEDICINE (2021)

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Article Virology

Antiviral Activity of Chrysin against Influenza Virus Replication via Inhibition of Autophagy

Seong-Ryeol Kim et al.

Summary: Chrysin demonstrates potent antiviral activity against A/PR/8 influenza virus by inhibiting viral infection at the early stages of the replication cycle, mainly through activation of mTOR and suppression of autophagy.

VIRUSES-BASEL (2021)

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Review Virology

Clinical Update of Severe Fever with Thrombocytopenia Syndrome

Jun-Won Seo et al.

Summary: SFTS is an acute febrile illness caused by the SFTSV virus, primarily transmitted by tick bites, with a high mortality rate and lack of established treatment strategies. Current treatments for SFTS include antiviral agents and other specific methods.

VIRUSES-BASEL (2021)

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Article Pharmacology & Pharmacy

Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting Mpro and Ameliorates Pulmonary Inflammation

Ting Xiao et al.

Summary: A new SARS-CoV-2 M-pro inhibitor, myricetin, was discovered in this study with potent inhibitory activity through interactions with the enzyme's binding pocket via hydrogen bonds and pi-pi stacking. Myricetin showed strong inhibitory effects on viral replication by binding to SARS-CoV-2 M-pro. Additionally, it exhibited potent inhibitory effects on pulmonary inflammation, making it a potential drug for the treatment of COVID-19 symptoms.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Materials Science, Multidisciplinary

A New Sterilization Strategy Using TiO2 Nanotubes for Production of Free Radicals that Eliminate Viruses and Application of a Treatment Strategy to Combat Infections Caused by Emerging SARS-CoV-2 during the COVID-19 Pandemic

Reham Z. Hamza et al.

Summary: The study utilized synthesized TiO2-NPs nanotubes for disinfection of SARS-CoV-2, showing strong antiviral activity with low cytotoxicity. Further studies are recommended to explore complex interactions with natural compounds to enhance antiviral efficacy and reduce cytotoxicity.

COATINGS (2021)

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Article Infectious Diseases

Strawberry and Ginger Silver Nanoparticles as Potential Inhibitors for SARS-CoV-2 Assisted by In Silico Modeling and Metabolic Profiling

Mohammad M. Al-Sanea et al.

Summary: The study conducted research on silver nanoparticles synthesized using strawberry and ginger extracts to explore their inhibitory potential against SARS-CoV-2, alongside an in sillico study to investigate the chemical compounds responsible for the antiviral properties.

ANTIBIOTICS-BASEL (2021)

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Review Nanoscience & Nanotechnology

Green synthesized plant-based silver nanoparticles: therapeutic prospective for anticancer and antiviral activity

Nancy Jain et al.

Summary: Nanotechnology plays a key role in medical science, with plant constituents showing great potential for synthesizing green silver nanoparticles. This review emphasizes the potential applications of Phyto-based AgNPs in anticancer and antiviral activities, along with their mechanisms of action.

MICRO AND NANO SYSTEMS LETTERS (2021)

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Review Tropical Medicine

Anti-viral and anti-inflammatory effects of kaempferol and quercetin and COVID-2019: A scoping review

Mohammad Reza Khazdair et al.

Summary: Flavonoids like kaempferol and quercetin exhibit antiviral, antioxidant, anti-inflammatory, and immunomodulatory effects against SARS-CoV-2, which may have beneficial effects in controlling or treating COVID-19.

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2021)

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Article Integrative & Complementary Medicine

Anti-influenza A virus activity of two Newtonia species and the isolated compound myricetin-3-o-rhamnoside

Katlego E. Motlhatlego et al.

Summary: The study found that the leaf extracts of Newtonia hildebrandtii and N. buchananii had significant antiviral activity against the H1N1 influenza virus. Myricitrin in the extracts was most effective in inhibiting viral attachment and entry stages. These findings support further research on these plants and compounds for controlling viral infections.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2021)

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Article Multidisciplinary Sciences

In silico validation of potent phytochemical orientin as inhibitor of SARS-CoV-2 spike and host cell receptor GRP78 binding

Arijit Bhowmik et al.

Summary: The current global health crisis is the outbreak of COVID-19 caused by SARS-CoV-2, with no effective treatment or vaccine developed yet. Orientin, a natural flavonoid with multiple beneficial effects, shows potential in interfering with the interaction of SARS-CoV-2 spike glycoprotein and their host receptor, suggesting it as a promising precautionary or therapeutic measure for COVID-19.

HELIYON (2021)

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Review Multidisciplinary Sciences

Traditional foods with their constituent's antiviral and immune system modulating properties

Md. Mahbubur Rahman et al.

Summary: This review explores traditional foods with antiviral and immune-boosting properties that can help individuals combat viral infections, particularly coronaviruses and other RNA viruses. Some foods contain bioactive compounds that exhibit significant antiviral effects against various viruses, similar to antiviral drugs used for SARS and MERS. The discussion of body shielding and immune-modulating foods aims to determine their efficacy against viral infections, especially SARS-CoV-2.

HELIYON (2021)

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Review Immunology

A review: Mechanism of action of antiviral drugs

Shamaila Kausar et al.

Summary: Antiviral drugs are a class of medicines used to treat viral infections, with strategies focusing on targeting the viruses themselves or host cell factors. Viruses can cause various serious diseases in humans, animals, and plants, and the action mechanism of antiviral drugs includes inhibiting viral nucleic acid synthesis and enhancing cell resistance to viruses.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2021)

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Article Integrative & Complementary Medicine

Molecular docking analysis of rutin reveals possible inhibition of SARS-CoV-2 vital proteins

Fazlur Rahman et al.

Summary: The study found that rutin can bind to key proteins of SARS-CoV-2 and exhibits promising drug candidate properties, suggesting further research to explore its potential use as a dietary supplement against COVID-19.

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE (2021)

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Review Tropical Medicine

Pharmacological aspects of fisetin

Lucia Dwi Antika et al.

Summary: Plant-derived products rich diet plays a crucial role in human health, with fisetin being a hydrophobic polyphenolic compound found primarily in edible plants. Fisetin exhibits various pharmacological effects such as antioxidant, anti-inflammatory, and anti-carcinogenic properties, making it a promising candidate for further research on the prevention and treatment of diseases.

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2021)

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Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

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Review Public, Environmental & Occupational Health

Remdesivir and its antiviral activity against COVID-19: A systematic review

Andri Frediansyah et al.

Summary: Remdesivir exhibits potent antiviral activities against SARS-CoV-2 and has shown efficacy in treating COVID-19 patients in clinical practice, but further efficacy assessments in clinical trials are needed.

CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH (2021)

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Review Biotechnology & Applied Microbiology

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Tariq Khan et al.

Summary: Plant-based compounds show potential in fighting coronaviruses, with active ingredients like glycyrrhizin demonstrating promising results. These compounds act on the virus through various mechanisms, offering a potential alternative for COVID-19 treatment.

BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2021)

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Review Instruments & Instrumentation

Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies

Shimon Ben-Shabat et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound

Nouran M. Fahmy et al.

CHEMISTRY & BIODIVERSITY (2020)

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Article Public, Environmental & Occupational Health

The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned?

Noah C. Peeri et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2020)

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Review Virology

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Salima Lalani et al.

VIRUSES-BASEL (2020)

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Article Pharmacology & Pharmacy

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

Canrong Wu et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Microbiology

Quercetin Blocks Ebola Virus Infection by Counteracting the VP24 Interferon-Inhibitory Function

Elisa Fanunza et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Article Pharmacology & Pharmacy

Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway

Wenmiao Li et al.

ANTIVIRAL RESEARCH (2020)

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Article Cell Biology

Ebola virus glycoprotein GP1-host cell-surface HSPA5 binding site prediction

Abdo A. Elfiky

CELL STRESS & CHAPERONES (2020)

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Review Immunology

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

Betsy J. Barnes et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Infectious Diseases

COVID-19 spike-host cell receptor GRP78 binding site prediction

Ibrahim M. Ibrahim et al.

JOURNAL OF INFECTION (2020)

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Letter Surgery

Why the immune system fails to mount an adaptive immune response to a COVID-19 infection

Pedram Ahmadpoor et al.

TRANSPLANT INTERNATIONAL (2020)

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Article Pharmacology & Pharmacy

Bioassay-guided isolation of anti-hepatitis B virus flavonoid myricetin-3-O-rhamnoside along with quercetin from Guiera senegalensis leaves

Mohammad K. Parvez et al.

SAUDI PHARMACEUTICAL JOURNAL (2020)

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Article Biotechnology & Applied Microbiology

In silico Molecular Docking Analysis Targeting SARS-CoV-2 Spike Protein and Selected Herbal Constituents

Anbazhagan Subbaiyan et al.

JOURNAL OF PURE AND APPLIED MICROBIOLOGY (2020)

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Article Medicine, General & Internal

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

Yeming Wang et al.

LANCET (2020)

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Article Immunology

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

Ya-Nan Zhang et al.

EMERGING MICROBES & INFECTIONS (2020)

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Letter Critical Care Medicine

COVID-19 cytokine storm: the interplay between inflammation and coagulation

Ricardo J. Jose et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Discordant Activity of Kaempferol Towards Dengue Virus and Japanese Encephalitis Virus

Chit Care et al.

MOLECULES (2020)

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Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19

B. Cao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Immunology

Covid-19 and autoimmunity

Michael Ehrenfeld et al.

AUTOIMMUNITY REVIEWS (2020)

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Article Pharmacology & Pharmacy

Structure-activity relationship of flavonoid bifunctional inhibitors against Zika virus infection

Min Zou et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article Virology

Possible SARS-coronavirus 2 inhibitor revealed by simulated molecular docking to viral main protease and host toll-like receptor

Xiaopeng Hu et al.

FUTURE VIROLOGY (2020)

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Review Pharmacology & Pharmacy

Medicinal Plants as Sources of Active Molecules Against COVID-19

Bachir Benarba et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Chemistry, Multidisciplinary

The Potential of Silver Nanoparticles for Antiviral and Antibacterial Applications: A Mechanism of Action

Atiqah Salleh et al.

NANOMATERIALS (2020)

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Article Chemistry, Medicinal

Structure-Based Virtual Screening to Discover Potential Lead Molecules for the SARS-CoV-2 Main Protease

Anuj Gahlawat et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)

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Article Microbiology

A Prospective, Randomized, Open-Label Trial of Early versus Late Favipiravir Therapy in Hospitalized Patients with COVID-19

Yohei Doi et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Editorial Material Integrative & Complementary Medicine

Kaempferol: an encouraging flavonoid for COVID-19

Roohollah Ahmadian et al.

BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2020)

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Article Biochemistry & Molecular Biology

Potential of Flavonoid-Inspired Phytomedicines against COVID-19

Wilfred Ngwa et al.

MOLECULES (2020)

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Review Chemistry, Medicinal

Naringenin, a flavanone with antiviral and anti-inflammatory effects: A promising treatment strategy againstCOVID-19

Helda Tutunchi et al.

PHYTOTHERAPY RESEARCH (2020)

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Article Virology

Antiviral activity of lycorine against Zika virus in vivo and in vitro

Huini Chen et al.

VIROLOGY (2020)

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Article Multidisciplinary Sciences

Potential bioactive glycosylated flavonoids as SARS-CoV-2 main protease inhibitors: A molecular docking and simulation studies

Sabri Ahmed Cherrak et al.

PLOS ONE (2020)

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Article Multidisciplinary Sciences

Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

Michael K. Lo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Nutrition & Dietetics

Antiviral Properties of Flavonoids and Delivery Strategies

Paolino Ninfali et al.

NUTRIENTS (2020)

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Review Microbiology

The Potential Intermediate Hosts for SARS-CoV-2

Jie Zhao et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Chemistry, Physical

Antiviral Effect of Visible Light-Sensitive CuxO/TiO2 Photocatalyst

Masahiro Miyauchi et al.

CATALYSTS (2020)

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Review Biochemistry & Molecular Biology

Anthocyanin Pigments: Beyond Aesthetics

Bindhu Alappat et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

Alkaloids: Therapeutic Potential against Human Coronaviruses

Burtram C. Fielding et al.

MOLECULES (2020)

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Article Virology

Luteolin inhibits respiratory syncytial virus replication by regulating the MiR-155/SOCS1/STAT1 signaling pathway

Saisai Wang et al.

VIROLOGY JOURNAL (2020)

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Article Pharmacology & Pharmacy

Vigna radiata (L.) R. Wilczek Extract Inhibits Influenza A Virus by Targeting Viral Attachment, Penetration, Assembly, and Release

Chieh-Wen Lo et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Microbiology

Anti-Influenza Strategies Based on Nanoparticle Applications

Klaudia Wieczorek et al.

PATHOGENS (2020)

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Article Biochemistry & Molecular Biology

Preparation, characterization, and evaluation of antioxidant activity and bioavailability of a self-nanoemulsifying drug delivery system (SNEDDS) for buckwheat flavonoids

Zhijuan Zhao et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2020)

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Review Virology

Curcumin as an Antiviral Agent

Morgan R. Jennings et al.

VIRUSES-BASEL (2020)

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Article Medicine, Research & Experimental

Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?

Yusuf A. Haggag et al.

MEDICAL HYPOTHESES (2020)

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Review Respiratory System

From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses

Zhixing Zhu et al.

RESPIRATORY RESEARCH (2020)

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Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Inhibition of African swine fever virus protease by myricetin and myricitrin

Seri Jo et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

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Article Nutrition & Dietetics

Induction of a 5-lipoxygenase product by daidzein is involved in the regulation of influenza virus replication

Yuka Horio et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2020)

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Article Agronomy

Antiviral activity of titanium dioxide nanostructures as a control strategy for broad bean strain virus in faba bean

Mohsen M. Elsharkawy et al.

PEST MANAGEMENT SCIENCE (2019)

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Article Infectious Diseases

Phloretin inhibits Zika virus infection by interfering with cellular glucose utilisation

Shih-Chao Lin et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2019)

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Article Biochemistry & Molecular Biology

Preparation and optimization of poly (lactic acid) nanoparticles loaded with fisetin to improve anti-cancer therapy

Chunlai Feng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Virology

An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method

Yingxian Yin et al.

JOURNAL OF MEDICAL VIROLOGY (2019)

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Article Chemistry, Medicinal

Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression

Haiyan Yan et al.

JOURNAL OF NATURAL MEDICINES (2019)

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Review Biochemistry & Molecular Biology

Isoflavones

Ludmila Krizova et al.

MOLECULES (2019)

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Article Chemistry, Multidisciplinary

Chalcones and Flavanones Bearing Hydroxyl and/or Methoxyl Groups: Synthesis and Biological Assessments

Goncalo P. Rosa et al.

APPLIED SCIENCES-BASEL (2019)

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Article Nanoscience & Nanotechnology

Antiviral potential of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea

Eman G. Haggag et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Immunology

Lycorine Derivative LY-55 Inhibits EV71 and CVA16 Replication Through Downregulating Autophagy

Huiqiang Wang et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

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Article Biochemistry & Molecular Biology

A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin

D. Benkerrou et al.

BIOPHYSICAL CHEMISTRY (2019)

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Review Pharmacology & Pharmacy

Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

Juanjuan Zhao et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Multidisciplinary Sciences

The citrus flavonoid naringenin impairs the in vitro infection of human cells by Zika virus

Allan Henrique Depieri Cataneo et al.

SCIENTIFIC REPORTS (2019)

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Review Pharmacology & Pharmacy

The Signaling Pathways, and Therapeutic Targets of Antiviral Agents: Focusing on the Antiviral Approaches and Clinical Perspectives of Anthocyanins in the Management of Viral Diseases

Pardis Mohammadi Pour et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Green synthesis of silver nanoparticles from medicinal plants and evaluation of their antiviral potential against chikungunya virus

Vikrant Sharma et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2019)

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Review Chemistry, Multidisciplinary

Calcium Phosphate Nanoparticles for Therapeutic Applications in Bone Regeneration

Tanya J. Levingstone et al.

NANOMATERIALS (2019)

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Article Multidisciplinary Sciences

Tandem mass tag-based quantitative proteomic analysis of lycorine treatment in highly pathogenic avian influenza H5N1 virus infection

Li Yang et al.

PEERJ (2019)

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Article Plant Sciences

Antiviral activity of ethanol extract of Lophatherum gracile against respiratory syncytial virus infection

Li-Feng Chen et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Article Immunology

Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells

Sujit Pujhari et al.

EMERGING MICROBES & INFECTIONS (2019)

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Article Pharmacology & Pharmacy

New micelle myricetin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment

Fengyuan Sun et al.

DRUG DELIVERY (2019)

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Review Pharmacology & Pharmacy

Baloxavir Marboxil

Danial E. Baker

HOSPITAL PHARMACY (2019)

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Article Medicine, General & Internal

Naringenin Ameliorates Renovascular Hypertensive Renal Damage by Normalizing the Balance of Renin-Angiotensin System Components in Rats

Zhizhi Wang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2019)

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Article Cell Biology

Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: another emerging application of nanomedicine

Hadi Ghaffari et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

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Article Biotechnology & Applied Microbiology

Larvicidal and pupicidal evaluation of silver nanoparticles synthesized using Aquilaria sinensis and Pogostemon cablin essential oils against dengue and zika viruses vector Aedes albopictus mosquito and its histopathological analysis

Hassan Ga'al et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Review Food Science & Technology

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Gary Williamson et al.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2018)

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Article Plant Sciences

Fabrication of surfactant-stabilized nanosuspension of naringenin to surpass its poor physiochemical properties and low oral bioavailability

Mayank Kumar Singh et al.

PHYTOMEDICINE (2018)

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Article Virology

Herpes simplex virus virucidal activity of MST-312 and epigallocatechin gallate

Prajakta Pradhan et al.

VIRUS RESEARCH (2018)

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Article Multidisciplinary Sciences

Probiotic Lactobacillus paracasei A221 improves the functionality and bioavailability of kaempferol-glucoside in kale by its glucosidase activity

Yosuke Shimojo et al.

SCIENTIFIC REPORTS (2018)

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Article Cell Biology

NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system

Gihan S. Gunaratne et al.

CELL CALCIUM (2018)

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Article Pharmacology & Pharmacy

Self-assembled amphiphilic chitosan nanoparticles for quercetin delivery to breast cancer cells

Rafael de Oliveira Pedro et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

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Article Pharmacology & Pharmacy

Tangeretin, an extract from Citrus peels, blocks cellular entry of arenaviruses that cause viral hemorrhagic fever

Ke Tang et al.

ANTIVIRAL RESEARCH (2018)

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Article Biotechnology & Applied Microbiology

Polyethylene glycol-coated zinc oxide nanoparticle: an efficient nanoweapon to fight against herpes simplex virus type 1

Ahmad Tavakoli et al.

NANOMEDICINE (2018)

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Article Immunology

Naringenin Modifies the Development of Lineage-Specific Effector CD4+ T Cells

Junpeng Wang et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Proceedings Paper Materials Science, Multidisciplinary

Acute And Subchronic Toxicity Studies Of SNEDDS (Self Nanoemulsifying Drug Delivery Systems) From Ethyl Acetate Extract Of Bay Leaf (Eugenia polyantha W.) with Virgin Coconut Oil As Oil Phase

F. Prihapsara et al.

INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS FOR BETTER FUTURE 2017 (2018)

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Article Chemistry, Multidisciplinary

Naringin-Chalcone Bioflavonoid-Protected Nanocolloids: Mode of Flavonoid Adsorption, a Determinant for Protein Extraction

Divya Mandial et al.

ACS OMEGA (2018)

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Review Virology

Evolution and Emergence of Pathogenic Viruses: Past, Present, and Future

Mohammad K. Parvez et al.

INTERVIROLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Green Tea Polyphenol Epigallocatechin-3-gallate-Alleviated Coxsackievirus B3-induced Myocarditis Through Inhibiting Viral Replication but Not Through Inhibiting Inflammatory Responses

Xiran He et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2017)

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Article Biochemistry & Molecular Biology

Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

Ji-Young Park et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)

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Article Immunology

Naringenin Ameliorates Acute Inflammation by Regulating Intracellular Cytokine Degradation

Lingtao Jin et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Virology

GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells

Minu Nain et al.

JOURNAL OF VIROLOGY (2017)

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Article Nanoscience & Nanotechnology

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Tejabhiram Yadavalli et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Article Agriculture, Multidisciplinary

Anti-equine arteritis virus activity of ethanolic extract and compounds from Origanum vulgare

Daiane Einhardt Blank et al.

SEMINA-CIENCIAS AGRARIAS (2017)

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Article Medicine, Research & Experimental

Naringenin ameliorates LPS-induced acute lung injury through its anti-oxidative and anti-inflammatory activity and by inhibition of the PI3K/AKT pathway

Minghong Zhao et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

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Article Infectious Diseases

The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro

Joseph T. Ortega et al.

AIDS RESEARCH AND THERAPY (2017)

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Review Food Science & Technology

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Hock Eng Khoo et al.

FOOD & NUTRITION RESEARCH (2017)

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Article Microbiology

Antiviral Properties of the Natural Polyphenols Delphinidin and Epigallocatechin Gallate against the Flaviviruses West Nile Virus, Zika Virus, and Dengue Virus

Angela Vazquez-Calvo et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Article Oncology

Nanoparticle Drones to Target Lung Cancer with Radiosensitizers and Cannabinoids

Wilfred Ngwa et al.

FRONTIERS IN ONCOLOGY (2017)

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Article Multidisciplinary Sciences

The citrus flavanone naringenin impairs dengue virus replication in human cells

Sandra Frabasile et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Identification of a flavonoid isolated from plum (Prunus domestica) as a potent inhibitor of Hepatitis C virus entry

Mihika Bose et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity

Aphinya Suroengrit et al.

SCIENTIFIC REPORTS (2017)

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Article Integrative & Complementary Medicine

Naringenin attenuates hepatitis B virus X protein-induced hepatic steatosis

Hung-Jen Lin et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

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Article Chemistry, Physical

Polymer type and molecular weight dictate the encapsulation efficiency and release of Quercetin from polymeric micelles

Suhair Sunoqrot et al.

COLLOID AND POLYMER SCIENCE (2017)

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Article Pharmacology & Pharmacy

Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists

Sergey A. Shiryaev et al.

ANTIVIRAL RESEARCH (2017)

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Article Pharmacology & Pharmacy

Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin

Minhua Peng et al.

ANTIVIRAL RESEARCH (2017)

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Article Medicine, Research & Experimental

Kaempferol ameliorates H9N2 swine influenza virus-induced acute lung injury by inactivation of TLR4/MyD88-mediated NF-κB and MAPK signaling pathways

Ruihua Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Article Cell Biology

Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin

Chung-Chun Wu et al.

JOURNAL OF BIOMEDICAL SCIENCE (2017)

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Article Pharmacology & Pharmacy

Antiviral activity of selected flavonoids against Chikungunya virus

Rafidah Lani et al.

ANTIVIRAL RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Production, Characterization and Evaluation of Kaempferol Nanosuspension for Improving Oral Bioavailability

Yew S. Qian et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2016)

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Article Pharmacology & Pharmacy

Quercetin-loaded poly (lactic-co-glycolic acid)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for the targeted treatment of liver cancer

Xin Guan et al.

DRUG DELIVERY (2016)

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Article Chemistry, Medicinal

Antiviral phenolics from the leaves of Cleistocalyx operculatus

Thi Kim Quy Ha et al.

FITOTERAPIA (2016)

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Article Biotechnology & Applied Microbiology

In Vitro Antiviral Activity of Cinnamomum cassia and Its Nanoparticles Against H7N3 Influenza A Virus

Munazza Fatima et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2016)

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Article Chemistry, Medicinal

Epigallocatechin gallate inhibits hepatitis B virus via farnesoid X receptor alpha

Jun Xu et al.

JOURNAL OF NATURAL MEDICINES (2016)

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Article Biochemistry & Molecular Biology

New Anti-HBV C-Boivinopyranosyl Flavones from Alternanthera philoxeroides

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MOLECULES (2016)

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(-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells

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Methylation of genistein and kaempferol improves their affinities for proteins

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Methylated flavonoids have greatly improved intestinal absorption and metabolic stability

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Methylation protects dietary flavonoids from rapid hepatic metabolism

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How can (-)-epigallocatechin gallate from green tea prevent HIV-1 infection? Mechanistic insights from computational modeling and the implication for rational design of anti-HIV-1 entry inhibitors

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Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: A randomized, double-blind, crossover trial.

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Human cytomegalovirus-inhibitory flavonoids: Studies on antiviral activity and mechanism of action

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Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in Moloney murine leukemia virus (PIM-1) kinase

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Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro

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Identification of natural compounds with antiviral activities against SARS-associated coronavirus

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Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41

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Inhibition of Epstein-Barr virus lytic cycle by (-)-epigallocatechin gallate

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A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro

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Inhibitory effects of (-)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1)

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Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits

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