☆ 4.7 Article

CHRNA5 Contributes to Hepatocellular Carcinoma Progression by Regulating YAP Activity

PHARMACEUTICS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Gastroenterology & Hepatology

Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes-Associated Protein 1 Activation and Transient Expansion of Stem-Like Cancer Cells

Darko Castven et al.

Summary: The induction of resistance to antiangiogenic therapy in hepatocellular carcinoma (HCC) may be driven by transient expansion of tumor-initiating cells (TICs) and activation of compensatory pro-oncogenic signaling pathways. Targeting TICs specifically could be an effective therapeutic strategy to overcome resistance in HCC.

HEPATOLOGY COMMUNICATIONS (2022)

添加到收藏夹

Article Environmental Sciences

Dichloroacetate attenuates the stemness of hepatocellular carcinoma cells via promoting nucleus-cytoplasm translocation of YAP

Duanyu Su et al.

Summary: The antitumor effects of dichloroacetate (DCA) in hepatocellular carcinoma (HCC) have been explored, showing that DCA may attenuate HCC cell stemness by activating the Hippo pathway and promoting nucleus-cytoplasm translocation of YAP. The inhibition of Hippo pathway partially abrogated DCA-induced effects on HCC cell stemness, suggesting DCA as a potential inhibitor for HCC progression.

ENVIRONMENTAL TOXICOLOGY (2021)

添加到收藏夹

Article Oncology

ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma

Qian Chen et al.

Summary: ACTN1 is significantly upregulated in HCC tissues and acts as a tumor promoter by suppressing Hippo signaling through physical interaction with MOB1. Therefore, ACTN1 may serve as a potential prognostic marker and therapeutic target for HCC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Article Medicine, Research & Experimental

YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

Ruize Gao et al.

Summary: The study reveals the critical role of YAP/TAZ in suppressing ferroptosis and establishing Sorafenib resistance in hepatocellular carcinoma (HCC). This highlights YAP/TAZ-based rewiring strategies as potential approaches to overcome HCC therapy resistance. The findings provide new insights into improving the efficacy of current therapies in cancer treatment.

EMBO MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Oncology

CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer

Huma Shehwana et al.

Summary: The study found that CHRNA5 expression in breast cancer cells was induced by E2 in a dose- and time-dependent manner, with higher levels in ER- tumors than ER+ tumors. Higher CHRNA5 expression was associated with a worse prognosis in untreated breast cancer patients, as well as with secondary E2 signaling. The study uncoupled primary and secondary target genes, revealing distinct clustering patterns in multiple public datasets.

CELLULAR ONCOLOGY (2021)

添加到收藏夹

Article Oncology

YAP promotes sorafenib resistance in hepatocellular carcinoma by upregulating survivin

Ting Sun et al.

Summary: Sorafenib resistance in HCC cells is promoted by YAP-induced survivin upregulation, while pharmacological inhibition of YAP can increase sensitivity to sorafenib. Targeting YAP may be a therapeutic strategy to enhance the antitumor effects of sorafenib in HCC.

CELLULAR ONCOLOGY (2021)

添加到收藏夹

Article Oncology

MiR-125b-5p Is Involved in Sorafenib Resistance through Ataxin-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma

Akihiro Hirao et al.

Summary: The study identified miR-125-5p as a key player in inducing sorafenib resistance in hepatocellular carcinoma by suppressing ataxin-1, inducing EMT, and promoting cancer stem cell properties, ultimately leading to a poor prognosis for patients.

CANCERS (2021)

添加到收藏夹

Article Oncology

E2F1 Maintains Gastric Cancer Stemness Properties by Regulating Stemness-Associated Genes

Yan Fu et al.

Summary: E2F1 plays a significant role in maintaining gastric cancer stemness properties and is closely associated with clinical characteristics and prognosis in gastric cancer patients. High expression of E2F1 is correlated with worse overall survival, suggesting its potential as a prognostic biomarker and therapeutic target in gastric cancer.

JOURNAL OF ONCOLOGY (2021)

添加到收藏夹

Article Oncology

Hippo pathway: Regulation, deregulation and potential therapeutic targets in cancer

Suman Mohajan et al.

Summary: The Hippo pathway serves as a master regulator of various cellular processes and its deregulation is associated with cancer. Despite the importance, the detailed functions of the components of the mammalian Hippo pathway in tumor biology are still unclear.

CANCER LETTERS (2021)

添加到收藏夹

Article Oncology

FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness

Jia-Jian Loh et al.

Summary: FSTL1 secreted by activated fibroblasts in the liver microenvironment enhances hepatocellular carcinoma malignancy, indicating it may be a potential diagnostic/prognostic biomarker and therapeutic target in HCC.

CANCER RESEARCH (2021)

添加到收藏夹

Review Cell Biology

Emerging Regulatory Mechanisms Involved in Liver Cancer Stem Cell Properties in Hepatocellular Carcinoma

Duoduo Lv et al.

Summary: Hepatocellular carcinoma (HCC) is mainly driven by liver cancer stem cells (LCSCs), which contribute to tumor progression, metastasis, and treatment resistance. However, the regulatory mechanisms of LCSCs in HCC are still unclear. Understanding the signaling pathways responsible for LCSC maintenance and survival may improve patient outcomes.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Tumor metastasis: Mechanistic insights and therapeutic interventions

Mengmeng Liu et al.

Summary: Cancer metastasis, responsible for the majority of cancer-related deaths worldwide, is a complex process involving various cellular and molecular mechanisms. In addition to traditional treatments, targeted therapy and immunotherapy have emerged as new options for the treatment of metastatic cancer, although there is still great room for improvement in cancer survival rates.

MEDCOMM (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Molecular mechanisms of chemo- and radiotherapy resistance and the potential implications for cancer treatment

Ya-Ping Liu et al.

Summary: Cancer is a leading cause of death worldwide, with surgery being the primary treatment approach. Resistance to radiotherapy and chemotherapy may lead to treatment failure. Understanding the molecular mechanisms of resistance can potentially improve treatment outcomes.

MEDCOMM (2021)

添加到收藏夹

Article Cell Biology

α5-nAChR modulates melanoma growth through the Notch1 signaling pathway

NingNing Dang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

The microenvironmental and metabolic aspects of sorafenib resistance in hepatocellular carcinoma

Shunjie Xia et al.

EBIOMEDICINE (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

IL-6/STAT3 Signaling Contributes to Sorafenib Resistance in Hepatocellular Carcinoma Through Targeting Cancer Stem Cells

Yu Li et al.

ONCOTARGETS AND THERAPY (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Hepatic Hippo signaling inhibits development of hepatocellular carcinoma

Yuchen Liu et al.

CLINICAL AND MOLECULAR HEPATOLOGY (2020)

添加到收藏夹

Article Oncology

YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway

Yuan Zhou et al.

CANCER CELL INTERNATIONAL (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

A global view of hepatocellular carcinoma: trends, risk, prevention and management

Ju Dong Yang et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

添加到收藏夹

Article Medicine, General & Internal

Nicotinic Acetylcholine Receptor Subunit Alpha-5 Promotes Radioresistance via Recruiting E2F Activity in Oral Squamous Cell Carcinoma

Che-Hsuan Lin et al.

JOURNAL OF CLINICAL MEDICINE (2019)

添加到收藏夹

Article Oncology

Acetylcholine receptors: Key players in cancer development

Jiawei Chen et al.

SURGICAL ONCOLOGY-OXFORD (2019)

添加到收藏夹

Review Oncology

Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities

Philamer C. Calses et al.

TRENDS IN CANCER (2019)

添加到收藏夹

Review Oncology

Chemotherapy for hepatocellular carcinoma: current status and future perspectives

Masafumi Ikeda et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2018)

添加到收藏夹

Article Neurosciences

Molecular function of 7 nicotinic receptors as drug targets

Cecilia Bouzat et al.

JOURNAL OF PHYSIOLOGY-LONDON (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in breast cancer

Sahika Cingir Koker et al.

PLOS ONE (2018)

添加到收藏夹

Review Medicine, General & Internal

Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches

Yan Fu et al.

YONSEI MEDICAL JOURNAL (2018)

添加到收藏夹

Article Oncology

Starting Dose of Sorafenib for the Treatment of Hepatocellular Carcinoma: A Retrospective, Multi-Institutional Study

Kim A. Reiss et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

添加到收藏夹

Article Oncology

Yes-associated protein (YAP) expression is involved in epithelial-mesenchymal transition in hepatocellular carcinoma

S. Wang et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2016)

添加到收藏夹

Article Medicine, General & Internal

Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis

Li-Shiun Chen et al.

EBIOMEDICINE (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Disease implications of the Hippo/YAP pathway

Steven W. Plouffe et al.

TRENDS IN MOLECULAR MEDICINE (2015)

添加到收藏夹

Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease, obesity and the metabolic syndrome

Peter Dietrich et al.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2014)

添加到收藏夹

Article Medicine, Research & Experimental

Cholinergic Receptors as Target for Cancer Therapy in a Systems Medicine Perspective

P. Russo et al.

CURRENT MOLECULAR MEDICINE (2014)

添加到收藏夹

Article Medicine, General & Internal

The Diagnosis and Treatment of Hepatocellular Carcinoma

Nisar P. Malek et al.

DEUTSCHES ARZTEBLATT INTERNATIONAL (2014)

添加到收藏夹

Article Oncology

Acetylcholine receptor pathway in lung cancer: New twists to an old story

Xiao-Min Niu et al.

WORLD JOURNAL OF CLINICAL ONCOLOGY (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Population-Attributable Fractions of Risk Factors for Hepatocellular Carcinoma in the United States

Tania M. Welzel et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2013)

添加到收藏夹

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

添加到收藏夹

Article Biology

Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples

Gunter P. Wagner et al.

THEORY IN BIOSCIENCES (2012)

添加到收藏夹

Review Developmental Biology

Hippo signaling: growth control and beyond

Georg Halder et al.

DEVELOPMENT (2011)

添加到收藏夹

Review Medicine, General & Internal

Nicotine Addiction

Neal L. Benowitz

NEW ENGLAND JOURNAL OF MEDICINE (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

From smoking to lung cancer: the CHRNA5/A3/B4 connection

M. R. D. Improgo et al.

ONCOGENE (2010)

添加到收藏夹

Review Oncology

Epithelial-mesenchymal transition in hepatocellular carcinoma

Franziska van Zijl et al.

FUTURE ONCOLOGY (2009)

添加到收藏夹

Review Physiology

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

Edson X. Albuquerque et al.

PHYSIOLOGICAL REVIEWS (2009)

添加到收藏夹

Article Medicine, General & Internal

Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

添加到收藏夹

Article Pharmacology & Pharmacy

Neuronal nicotinic receptors: A perspective on two decades of drug discovery research

Stephen P. Arneric et al.

BIOCHEMICAL PHARMACOLOGY (2007)

添加到收藏夹

Review Chemistry, Medicinal

Central nicotinic receptors: Structure, function, ligands, and therapeutic potential

M. Novella Romanelli et al.

CHEMMEDCHEM (2007)

添加到收藏夹

Article Oncology

Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers

David Chi-Leung Lam et al.

CANCER RESEARCH (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.