期刊
PHARMACEUTICS
卷 13, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13111837
关键词
hollow microneedles; transdermal drug delivery; 3D printing; additive manufacturing; digital light processing; emerging technologies
资金
- AstraZeneca
- DfE PhD scholarships at Queen's University Belfast
- MDPI
The study introduced a digital light processing (DLP) method for 3D printing hollow microneedle arrays using commercial UV curable resin, optimizing print quality by evaluating the effect of print angle on needle geometries and conducting mechanical testing.
3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin. However, there is a need for a faster fabrication process with potential for easily exploring different geometries of MNs. In the current study, a digital light processing (DLP) method of 3D printing for fabrication of hollow MN arrays using commercial UV curable resin was proposed. Print quality was optimised by assessing the effect of print angle on needle geometries. Mechanical testing of MN arrays was conducted using a texture analyser. Angled prints were found to produce prints with geometries closer to the CAD designs. Curing times were found to affect the mechanical strength of MNs, with arrays not breaking when subjected to 300 N of force but were bent. Overall, DLP process produced hollow MNs with good mechanical strength and depicts a viable, quick, and efficient method for the fabrication of hollow MN arrays.
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