Potential Applications and Functional Roles of Exosomes in Cardiometabolic Disease

Article Cardiac & Cardiovascular Systems

High miR-133a levels in the circulation anticipates presentation of clinical events in familial hypercholesterolaemia patients

Rafael Escate et al.

Summary: The study investigated the predictive role of miRNAs in atherosclerotic plaque progression and clinical event presentation in FH patients, identifying miR-133a as the best predictor for CVE.

CARDIOVASCULAR RESEARCH (2021)

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Article Cell Biology

RAB31 marks and controls an ESCRT-independent exosome pathway

Denghui Wei et al.

Summary: RAB31 plays a dual role in exosome biogenesis by driving ILVs formation and suppressing the fusion of MVEs with lysosomes, providing a better understanding of the exosome biogenesis process.

CELL RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Morphomolecular Characterization of Serum Nanovesicles From Microbiomes Differentiates Stable and Infarcted Atherosclerotic Patients

Camila Rodrigues Moreno et al.

Summary: Microbial communities play a crucial role in maintaining health or causing diseases, with pathogenic archaea potentially contributing to worse outcomes in atherosclerosis-related conditions like AMI. Different levels of protective extracellular vesicles, including exosomes, were found in stable atherosclerotic patients and healthy controls compared to groups with severe AMI, indicating their potential role in trapping and degrading harmful antigens and MMP9 to prevent plaque rupture. This research suggests that morphomolecular characterization and quantification of extracellular vesicles in serum could serve as a promising prognostic biomarker for CAD.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo

Elisa Lazaro-Ibanez et al.

Summary: The study evaluated the effects of five different tracers on the in vivo biodistribution of extracellular vesicles, finding that indium and DiR were the most sensitive tracers. Genetic modification of EVs may impact their physiological distribution in vivo.

ACS NANO (2021)

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Article Cell Biology

MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice

Wei Ying et al.

Summary: Insulin resistance is a significant issue in type 2 diabetes and obesity, while anti-inflammatory M2-like macrophages play a role in maintaining metabolic balance. Research has shown that exosomes secreted by M2 polarized macrophages contain miRNAs that can improve glucose tolerance and insulin sensitivity in obese mice. MiR-690, found in abundance in these exosomes, acts as an insulin sensitizer both in vivo and in vitro, suggesting it could be a potential therapeutic agent for metabolic diseases.

CELL METABOLISM (2021)

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Article Peripheral Vascular Disease

Urinary- and Plasma-Derived Exosomes Reveal a Distinct MicroRNA Signature Associated With Albuminuria in Hypertension

Javier Perez-Hernandez et al.

Summary: This study identified a signature of dysregulated circulating miRNAs associated with albuminuria in hypertension. In particular, miR-26a in exosomes seemed to play a key role in the regulation of TGF-beta, a relevant effector in kidney damage.

HYPERTENSION (2021)

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Article Nanoscience & Nanotechnology

Inhibition of Circulating Exosomal miRNA-20b-5p Accelerates Diabetic Wound Repair

Kai Chen et al.

Summary: Research found that exosome-derived miRNA from diabetic patients slows down wound healing process by suppressing vascular endothelial growth factor A expression.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Cell Biology

Circulating exosomes repair endothelial cell damage by delivering miR-193a-5p

Chang Cao et al.

Summary: Circulating exosomes shuttle between cells via dynamin and deliver miR-193a-5p to protect endothelial cells from oxidative stress damage via ACVR1, indicating a potential therapeutic target for cardiovascular diseases.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Multidisciplinary Sciences

High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance

Anil Kumar et al.

Summary: This study reveals that lean mice become insulin resistant after being administered exosomes isolated from the feces of obese mice fed a high-fat diet or from patients with type II diabetes. The altered lipid composition of exosomes from high-fat diet-fed mice affects the uptake by macrophages and hepatocytes, leading to inhibition of the insulin signaling pathway. Exosome-derived phosphatidylcholine activates AhR, inhibiting the expression of genes essential for activation of the insulin signaling pathway.

NATURE COMMUNICATIONS (2021)

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Article Biochemical Research Methods

Label-free proteomic analysis of serum exosomes from paroxysmal atrial fibrillation patients

Hanwen Ni et al.

Summary: Atrial fibrillation (AF) is a common cardiac rhythm disorder with complex mechanisms. This study analyzed the protein content of serum exosomes from AF patients and healthy donors, revealing changes in abundance and potential functions of exosomal proteins associated with AF. The results provide new insights into the complement system and protein folding in AF.

CLINICAL PROTEOMICS (2021)

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Article Biochemistry & Molecular Biology

Similarities and Differences in Extracellular Vesicle Profiles between Ischaemic Stroke and Myocardial Infarction

Laura Otero-Ortega et al.

Summary: The study analyzed the content of circulating EVs in patients with IS and MI, finding common proteins and miRNAs as well as differences between the two groups. The research suggests a relationship between circulating EV content and the patient's disease state, with certain proteins and miRNAs participating in both diseases while others are specific to IS patients.

BIOMEDICINES (2021)

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Review Pharmacology & Pharmacy

Clinical applications for exosomes: Are we there yet?

Dany Perocheau et al.

Summary: Exosomes, a subset of extracellular vesicles, play a crucial role in cell-cell communication and have shown promising potential as diagnostic biomarkers and therapeutic carriers. Their reduced immunogenicity and ability to cross physiological barriers make them an appealing option for clinical application.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

Dashuai Zhu et al.

Summary: Intrapericardial injection is established as a safe and effective method for delivering therapeutic-bearing hydrogels to the heart, promoting cardiac repair.

NATURE COMMUNICATIONS (2021)

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Review Cardiac & Cardiovascular Systems

Pathophysiology of heart failure

Robert H. G. Schwinger

Summary: Heart failure is a global epidemic disease that affects about 1% to 2% of the population worldwide, with varying etiology and phenotype. Various cellular, structural, and neurohumoral modulations occur after a cardiac injury, leading to a complex pathophysiology involving activation of different systems and the need for personalized diagnostic and therapeutic approaches.

CARDIOVASCULAR DIAGNOSIS AND THERAPY (2021)

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Article Medicine, Research & Experimental

Plasma exosomal miR-596: a novel biomarker predicts survival in patients with idiopathic pulmonary artery hypertension

Yang Huang et al.

Summary: High levels of plasma exosomal miR-596 were significantly associated with disease severity and poor prognosis of patients with idiopathic pulmonary arterial hypertension (IPAH).

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2021)

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Review Materials Science, Biomaterials

Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications

Md Nurul Huda et al.

Summary: Exosomes are cell-derived vesicles containing various active biomolecules, with potential for drug delivery and early disease diagnosis.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Pharmacology & Pharmacy

Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

Amin Mirzaaghasi et al.

Summary: Exosomes have potential as drug delivery vehicles due to their ability to selectively deliver therapeutic cargoes to disease sites. The in vivo behaviors of exosomes are affected by pathophysiological conditions, and exosomes exhibit specific behaviors in sepsis mice compared to liposomes. This suggests that exosome-based therapeutics may be effective in managing sepsis and septic shock.

PHARMACEUTICS (2021)

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Review Cell Biology

Exosomes and Obesity-Related Insulin Resistance

Li-Min Lei et al.

Summary: Exosomes are extracellular vesicles that play a crucial role in delivering signal molecules from donor cells to recipient cells, with a cargo that includes proteins, DNA, and RNA targeting recipient tissues and organs, influencing disease development. Research indicates that exosomes are significant in the development of insulin resistance caused by obesity, showing promise for diagnosis and therapy of insulin resistance.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

Jialu Yao et al.

Summary: Myocardial infarction is the most common cause of death worldwide, with heart failure becoming a major determinant of adverse prognosis in survivors. Exosome spray (EXOS) based on MSC exosomes and biomaterials shows promise in improving heart function, reducing fibrosis, and promoting angiomyogenesis for heart repair, making it a feasible and safe strategy for future therapeutic delivery.

ACS NANO (2021)

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Review Biochemistry & Molecular Biology

Exosomes as New Biomarkers and Drug Delivery Tools for the Prevention and Treatment of Various Diseases: Current Perspectives

Qi Liu et al.

Summary: Exosomes are nano-sized vesicles secreted by cells, containing various biological molecules and serving as important mediators for long-distance cell-to-cell communication. They are also utilized as effective drug delivery tools and clinical diagnostic biomarkers, playing a crucial role in the prevention and treatment of various diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers

Nika Kucuk et al.

Summary: Exosomes are emerging as important therapeutic biomaterials for delivering drugs and other therapeutic agents in various diseases. They are highly promising carriers with diverse preparation methods, emphasizing their importance and effectiveness in treating diseases such as cancer, cardiovascular, and neurodegenerative diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

The role of lipids in exosome biology and intercellular communication: Function, analytics and applications

Javier Donoso-Quezada et al.

Summary: Exosomes are important extracellular vesicles with compositions related to the progression of various diseases. Lipids, as crucial components of exosomes, play significant roles in exosome biology and intercellular communication. Exosome lipidomics is an emerging discipline that offers insights into the discovery of new lipid species for biomedical applications.

TRAFFIC (2021)

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Article Biotechnology & Applied Microbiology

Hydrogel-load exosomes derived from dendritic cells improve cardiac function via Treg cells and the polarization of macrophages following myocardial infarction

Youming Zhang et al.

Summary: A novel drug delivery system incorporating alginate hydrogel was developed to continuously release DEXs, enhancing the therapeutic effects of DEXs in improving cardiac function after MI.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Cell Biology

The Micro-RNA Cargo of Extracellular Vesicles Released by Human Adipose Tissue-Derived Mesenchymal Stem Cells Is Modified by Obesity

Alfonso Eirin et al.

Summary: Obesity alters the miRNA expression profile and size of human adipose mesenchymal stem/stromal cell-derived extracellular vesicles (EVs), reducing their capacity to repair injured cells and modulate important injury pathways in recipient cells. These observations may guide the development of novel strategies to improve healing and repair in obese individuals.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Medicine, Research & Experimental

Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets

Chen Wang et al.

Summary: Exosomes, nanosized lipid vesicles originating from the endosomal system, have been intensively studied for their roles in intercellular communication and their potential impacts on atherosclerosis. Recent research has focused on exosomal changes associated with atherosclerosis, cellular origins, potential functional cargos, and their potential as biomarkers and drug carriers for managing atherosclerosis.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction

Xudong Zhang et al.

Summary: This study revealed that miR-320 functions differently in various cell types of the heart during the progression of heart failure, with overexpression in CMs exacerbating cardiac dysfunction, and in CFs alleviating cardiac fibrosis and hypertrophy. The effects of miR-320 were mediated through targeting different downstream signaling pathways in CMs and CFs, and could be influenced by upstream regulators such as Ago2 and cell-type-specific transcription factors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Medicine, Research & Experimental

Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model

Zhelong Li et al.

Summary: The study demonstrated that exosome-mediated delivery of Ldlr mRNA effectively restored receptor expression in Ldlr(-/-) mice, treating the disorders and reducing atherosclerotic plaque formation. Exo(Ldlr) treatment significantly decreased lipid deposition in the liver and lowered LDL-cholesterol levels in the treated mice, providing a new therapeutic approach for FH patients and managing atherosclerosis.

THERANOSTICS (2021)

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Article Nutrition & Dietetics

Comparative and functional analysis of plasma membrane-derived extracellular vesicles from obese vs. nonobese women

Fernando Santamaria-Martos et al.

CLINICAL NUTRITION (2020)

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Article Biochemistry & Molecular Biology

Knockout of beta-2 microglobulin enhances cardiac repair by modulating exosome imprinting and inhibiting stem cell-induced immune rejection

Lianbo Shao et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

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Review Cell & Tissue Engineering

Preclinical translation of exosomes derived from mesenchymal stem/stromal cells

Fanny M. Elahi et al.

STEM CELLS (2020)

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Article Endocrinology & Metabolism

Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

Baoyan Fan et al.

DIABETOLOGIA (2020)

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Review Medicine, Research & Experimental

MicroRNA expression signatures of atrial fibrillation: The critical systematic review and bioinformatics analysis

Nan-Nan Shen et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Exosomal miRNAs as potential biomarkers for acute myocardial infarction

Jia Su et al.

IUBMB LIFE (2020)

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Article Cell Biology

Quality and efficiency assessment of six extracellular vesicle isolation methods by nano-flow cytometry

Ye Tian et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Cardiac & Cardiovascular Systems

Interleukin-10 Deficiency Alters Endothelial Progenitor Cell-Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment

Yue Yujia et al.

CIRCULATION RESEARCH (2020)

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Article Biotechnology & Applied Microbiology

Exosome-Mediated Transfer of Anti-miR-33a-5p from Transduced Endothelial Cells Enhances Macrophage and Vascular Smooth Muscle Cell Cholesterol Efflux

Alexis Stamatikos et al.

HUMAN GENE THERAPY (2020)

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Review Biochemistry & Molecular Biology

Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging

Yong Weon Yi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes

Jorge Larios et al.

JOURNAL OF CELL BIOLOGY (2020)

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Article Multidisciplinary Sciences

Tetraspanin-6 negatively regulates exosome production

Rania Ghossoub et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Reproductive Biology

Proteomic and lipidomic analysis of exosomes derived from ovarian cancer cells and ovarian surface epithelial cells

Lin Cheng et al.

JOURNAL OF OVARIAN RESEARCH (2020)

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Article Cell Biology

Anti-CD3 Antibody Treatment Reduces Scar Formation in a Rat Model of Myocardial Infarction

Bernhard Wernly et al.

CELLS (2020)

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Article Agriculture, Dairy & Animal Science

Expression of Serum Exosomal miRNA 122 and Lipoprotein Levels in Dogs Naturally Infected by Leishmania infantum: A Preliminary Study

Antonio Di Loria et al.

ANIMALS (2020)

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Article Cell Biology

Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy

Rongfeng Shi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

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Article Cell & Tissue Engineering

Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

Jin Chen et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Cardiac & Cardiovascular Systems

Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017

Simon Yadgir et al.

CIRCULATION (2020)

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Review Peripheral Vascular Disease

Microparticles (Exosomes) and Atherosclerosis

Ya-Ting Chen et al.

CURRENT ATHEROSCLEROSIS REPORTS (2020)

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Article Peripheral Vascular Disease

Hypertension

J. Radermacher

GEFASSCHIRURGIE (2020)

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Article Cell Biology

Differential expression of microRNA in serum fractions and association of Argonaute 1 microRNAs with heart failure

Eti Meiri et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Multidisciplinary Sciences

A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells

Bong Hwan Sung et al.

NATURE COMMUNICATIONS (2020)

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Article Biotechnology & Applied Microbiology

The Course of Circulating Small Extracellular Vesicles in Patients Undergoing Surgical Aortic Valve Replacement

Andreas Weber et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Review Cardiac & Cardiovascular Systems

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

Ricardo Cerqueira de Abreu et al.

NATURE REVIEWS CARDIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

State-of-the-art exosome loading and functionalization techniques for enhanced therapeutics: a review

Javier Donoso-Quezada et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2020)

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Review Peripheral Vascular Disease

Exosomes: Multifaceted Messengers in Atherosclerosis

Hongyun Wang et al.

CURRENT ATHEROSCLEROSIS REPORTS (2020)

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Review Developmental Biology

Mechanisms of heart valve development and disease

Anna O'Donnell et al.

DEVELOPMENT (2020)

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Review Cardiac & Cardiovascular Systems

Epidemiology of heart failure

Amy Groenewegen et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

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Article Biochemistry & Molecular Biology

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Ayuko Hoshino et al.

CELL (2020)

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Article Physiology

Serum Exosomal MicroRNA-21, MicroRNA-126, and PTEN Are Novel Biomarkers for Diagnosis of Acute Coronary Syndrome

Hao Ling et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Letter Medicine, General & Internal

Trends in the Prevalence of Metabolic Syndrome in the United States, 2011-2016

Grishma Hirode et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Cell Biology

Circulating exosomal long non-coding RNAs in patients with acute myocardial infarction

Mei-Li Zheng et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Cell Biology

Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles

Allaura S. Cone et al.

BMC MOLECULAR AND CELL BIOLOGY (2020)

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Article Engineering, Biomedical

Monocyte mimics improve mesenchymal stem cell-derived extracellular vesicle homing in a mouse MI/RI model

Ning Zhang et al.

BIOMATERIALS (2020)

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Article Biotechnology & Applied Microbiology

Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice

Yuto Nakamura et al.

MOLECULAR THERAPY (2020)

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Article Cell & Tissue Engineering

被撤回的出版物: Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy (Retracted article. See vol. 13, 2022)

Qin He et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Cell & Tissue Engineering

Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway

Muyu Yu et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Cell & Tissue Engineering

Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway

Wei Liu et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Biochemistry & Molecular Biology

Expression level and diagnostic value of exosomalNEAT1/miR-204/MMP-9 in acuteST-segment elevation myocardial infarction

Zhenzhen Chen et al.

IUBMB LIFE (2020)

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Article Cell Biology

The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation

Ann L. Wozniak et al.

JOURNAL OF CELL BIOLOGY (2020)

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Article Cell Biology

ECM deposition is driven by caveolin-1-dependent regulation of exosomal biogenesis and cargo sorting

Lucas Albacete-Albacete et al.

JOURNAL OF CELL BIOLOGY (2020)

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Review Chemistry, Multidisciplinary

Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance

Shubham Salunkhe et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Biochemistry & Molecular Biology

The crosstalk of ABCA1 and ANXA1: a potential mechanism for protection against atherosclerosis

Xin Shen et al.

MOLECULAR MEDICINE (2020)

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Review Pharmacology & Pharmacy

Extracellular vesicles and cardiovascular system: Biomarkers and Cardioprotective Effectors

Saveria Femmino et al.

VASCULAR PHARMACOLOGY (2020)

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Review Cell Biology

Uptake and Fate of Extracellular Membrane Vesicles: Nucleoplasmic Reticulum-Associated Late Endosomes as a New Gate to Intercellular Communication

Denis Corbeil et al.

CELLS (2020)

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Article Cell Biology

Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee

Felix Royo et al.

CELLS (2020)

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Article Endocrinology & Metabolism

Effect of diabetes on exosomal miRNA profile in patients with obesity

Hyoshik Kim et al.

BMJ OPEN DIABETES RESEARCH & CARE (2020)

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Review Chemistry, Medicinal

Exosomal miRNAs as Potential Diagnostic Biomarkers in Alzheimer's Disease

Ida Manna et al.

PHARMACEUTICALS (2020)

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Article Cell Biology

Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications

Xiaojuan Zhang et al.

DEVELOPMENTAL CELL (2020)

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Article Multidisciplinary Sciences

Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice

Carlos Castano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell Biology

Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy

Kenta Hirai et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Physiology

The Role(s) of Eicosanoids and Exosomes in Human Parturition

Eman Mosaad et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Cell Biology

MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1

Tsai-Chun Lai et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Medicine, General & Internal

Exosomes in Cardiovascular Diseases

Marta Zara et al.

DIAGNOSTICS (2020)

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Article Engineering, Biomedical

Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles

Shiyu Liu et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Article Cardiac & Cardiovascular Systems

M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment

Shaojun Liu et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

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Article Medicine, Research & Experimental

Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice

Xueying Zhou et al.

THERANOSTICS (2020)

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Review Pharmacology & Pharmacy

Exosomes in Therapy: Engineering, Pharmacokinetics and Future Applications

Claudia Arenaccio et al.

CURRENT DRUG TARGETS (2019)

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Article Cardiac & Cardiovascular Systems

miRNA Profiling of Exosomes from Spontaneous Hypertensive Rats Using Next-Generation Sequencing

Xiaoyan Liu et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2019)

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Review Cell Biology

MiR-214 is an important regulator of the musculoskeletal metabolism and disease

Youqiang Sun et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Mesenchymal stromal cell-derived exosomes attenuatemyocardial ischaemia-reperfusion injury throughmiR-182-regulated macrophage polarization

Jinxuan Zhao et al.

CARDIOVASCULAR RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration

Alessandra Ciullo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Regenerative Cardiovascular Therapies: Stem Cells and Beyond

Bernhard Wernly et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Cell Biology

Exosomes derived from SDF1-overexpressing mesenchymal stem cells inhibit ischemic myocardial cell apoptosis and promote cardiac endothelial microvascular regeneration in mice with myocardial infarction

Xu-He Gong et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Cell Biology

Adipose-derived exosomes: A novel adipokine in obesity-associated diabetes

Bo Zhang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Multidisciplinary Sciences

A lipase-independent pathway of lipid release and immune modulation by adipocytes

Stephen E. Flaherty et al.

SCIENCE (2019)

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Review Biochemistry & Molecular Biology

Exosomes: biogenesis, biologic function and clinical potential

Yuan Zhang et al.

CELL AND BIOSCIENCE (2019)

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Review Cell Biology

Exosome in Cardiovascular Diseases: A Complex World Full of Hope

Gloria Bellin et al.

CELLS (2019)

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Article Engineering, Biomedical

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

Peng Zhang et al.

NATURE BIOMEDICAL ENGINEERING (2019)

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Article Cardiac & Cardiovascular Systems

Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy

Tingsen Benson Lim et al.

CARDIOVASCULAR RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Reassessment of Exosome Composition

Dennis K. Jeppesen et al.

CELL (2019)

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Article Physiology

Skeletal muscle-derived exosomes regulate endothelial cell functions via reactive oxygen species-activated nuclear factor-κB signalling

Yaohui Nie et al.

EXPERIMENTAL PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Extra Purified Exosomes from Human Placenta Contain an Unpredictable Small Number of Different Major Proteins

Evgeniya E. Burkova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Effect of Ischemic Preconditioning and Postconditioning on Exosome-Rich Fraction microRNA Levels, in Relation with Electrophysiological Parameters and Ventricular Arrhythmia in Experimental Closed-Chest Reperfused Myocardial Infarction

Andreas Spannbauer et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Immunology

Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer

Payal Tiwari et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma

Liang Yang et al.

MOLECULAR CANCER (2019)

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Review Pharmacology & Pharmacy

miR-155 in the Resolution of Atherosclerosis

Robyn Bruen et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Review Medicine, Research & Experimental

Exosomes: An emerging factor in atherosclerosis

Wang Yanan et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Biochemistry & Molecular Biology

The microRNA in ventricular remodeling: the miR-30 family

Xiaonan Zhang et al.

BIOSCIENCE REPORTS (2019)

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Article Multidisciplinary Sciences

Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo

Kyle Mentkowski et al.

SCIENTIFIC REPORTS (2019)

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Article Cardiac & Cardiovascular Systems

Hypertension and Heart Failure

Jeremy Slivnick et al.

HEART FAILURE CLINICS (2019)

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Review Cell Biology

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

Laura M. Doyle et al.

CELLS (2019)

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Article Cell Biology

Extracellular vesicle measurements with nanoparticle tracking analysis - An accuracy and repeatability comparison between NanoSight NS300 and ZetaView

Daniel Bachurski et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Review Biochemical Research Methods

Recent advances and challenges in the recovery and purification of cellular exosomes

Sergio Ayala-Mar et al.

ELECTROPHORESIS (2019)

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Review Medicine, Research & Experimental

Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome

Shunbun Kita et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Medicine, Research & Experimental

Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging

Xiao Lin et al.

LIFE SCIENCES (2019)

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Article Medicine, Research & Experimental

miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury

Wei Zilun et al.

LIFE SCIENCES (2019)

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Article Endocrinology & Metabolism

Macrophage-Derived microRNA-155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator-Activated Receptor Gamma

Jeanie B. Tryggestad et al.

OBESITY (2019)

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Article Medicine, Research & Experimental

Bone marrow mesenchymal stem cell-derived exosomes protect against myocardial infarction by promoting autophagy

Liyuan Zou et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2019)

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Article Medicine, General & Internal

Atherosclerosis

Peter Libby et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

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Review Cell Biology

Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus

Wenguang Chang et al.

CELLS (2019)

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Article Chemistry, Analytical

Electrokinetically Driven Exosome Separation and Concentration Using Dielectrophoretic-Enhanced PDMS-Based Microfluidics

Sergio Ayala-Mar et al.

ANALYTICAL CHEMISTRY (2019)

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Review Medicine, Research & Experimental

Adipocyte dedifferentiation in health and diseases

Tongxing Song et al.

CLINICAL SCIENCE (2019)

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Review Engineering, Biomedical

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

Wen Liao et al.

ACTA BIOMATERIALIA (2019)

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Article Multidisciplinary Sciences

Mechanisms of nuclear content loading to exosomes

Akira Yokoi et al.

SCIENCE ADVANCES (2019)

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Article Cell Biology

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

Claudiane Guay et al.

CELL METABOLISM (2019)

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Review Cardiac & Cardiovascular Systems

Immunity and Inflammation in Atherosclerosis

Dennis Wolf et al.

CIRCULATION RESEARCH (2019)

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Article Endocrinology & Metabolism

Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle

Mutsumi Katayama et al.

DIABETES (2019)

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Review Endocrinology & Metabolism

Obesity and dyslipidemia

Jelena Vekic et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

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Article Biochemistry & Molecular Biology

EVmiRNA: a database of miRNA profiling in extracellular vesicles

Teng Liu et al.

NUCLEIC ACIDS RESEARCH (2019)

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Review Biochemistry & Molecular Biology

The MicroRNA miR-155 Is Essential in Fibrosis

Mousa G. Eissa et al.

NON-CODING RNA (2019)

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Article Materials Science, Biomaterials

Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair

Chaoshan Han et al.

BIOMATERIALS SCIENCE (2019)

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Review Immunology

Roles of Exosomes Derived From Immune Cells in Cardiovascular Diseases

Runda Wu et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Surgery

Bariatric Surgery Is Accompanied by Changes in Extracellular Vesicle-Associated and Plasma Fatty Acid Binding Protein 4

Justyna K. Witczak et al.

OBESITY SURGERY (2018)

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Article Cell Biology

Pathways of production and delivery of hepatocyte exosomes

Li Chen et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2018)

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Article Chemistry, Multidisciplinary

Protein Profiling and Sizing of Extracellular Vesicles from Colorectal Cancer Patients via Flow Cytometry

Ye Tian et al.

ACS NANO (2018)

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Review Chemistry, Multidisciplinary

Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools

Song-pei Li et al.

ACTA PHARMACOLOGICA SINICA (2018)

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Review Biochemistry & Molecular Biology

Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes

Mahesh Appari et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

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Article Oncology

Mechanism of recipient cell-dependent differences in exosome uptake

Sayo Horibe et al.

BMC CANCER (2018)

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Review Cell Biology

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

Meng-yu Wu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Dermatology

Pathophysiology of the metabolic syndrome

Emma McCracken et al.

CLINICS IN DERMATOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

Extracellular vesicles in cardiovascular homeostasis and disease

Joshua D. Hutcheson et al.

CURRENT OPINION IN CARDIOLOGY (2018)

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Article Medicine, Research & Experimental

Reduced exosome miR-425 and miR-744 in the plasma represents the progression of fibrosis and heart failure

Lu Wang et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2018)

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Article Biotechnology & Applied Microbiology

The Impact of the CD9 Tetraspanin on Lentivirus Infectivity and Exosome Secretion

Kai O. Boker et al.

MOLECULAR THERAPY (2018)

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Article Multidisciplinary Sciences

Exosome purification based on PEG-coated Fe3O4 nanoparticles

Ming Chang et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

Exosome isolation from distinct biofluids using precipitation and column-based approaches

Tania Soares Martins et al.

PLOS ONE (2018)

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Review Medical Laboratory Technology

Macrophages under pressure: the role of macrophage polarization in hypertension

Sailesh C. Harwani

TRANSLATIONAL RESEARCH (2018)

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Article Cardiac & Cardiovascular Systems

Adipose-Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization

Zulong Xie et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

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Article Medicine, General & Internal

Hypertension

Suzanne Oparil et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

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Article Chemistry, Analytical

Magnetic-Based Microfluidic Device for On-Chip Isolation and Detection of Tumor-Derived Exosomes

Huiying Xu et al.

ANALYTICAL CHEMISTRY (2018)

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Article Medicine, Research & Experimental

Urinary exosome miR-146a is a potential marker of albuminuria in essential hypertension

Javier Perez-Hernandez et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

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Article Cardiac & Cardiovascular Systems

Exosome-Derived Dystrophin from Allograft Myogenic Progenitors Improves Cardiac Function in Duchenne Muscular Dystrophic Mice

Xuan Su et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2018)

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Article Nutrition & Dietetics

Bariatric surgery reduces CD36-bearing microvesicles of endothelial and monocyte origin

Jaco Botha et al.

NUTRITION & METABOLISM (2018)

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Article Multidisciplinary Sciences

Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice

Carlos Castano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Cardiac & Cardiovascular Systems

Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes for Angiogenesis

Chengwei Ju et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2018)

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Article Respiratory System

Circulating exosomal miR-92b-5p is a promising diagnostic biomarker of heart failure with reduced ejection fraction patients hospitalized for acute heart failure

Tao Wu et al.

JOURNAL OF THORACIC DISEASE (2018)

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Article Multidisciplinary Sciences

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Farid N. Faruqu et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2018)

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Article Cell Biology

Immunoaffinity-based isolation of melanoma cell-derived exosomes from plasma of patients with melanoma

Priyanka Sharma et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Biotechnology & Applied Microbiology

Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury

Chunxiao Wang et al.

MOLECULAR THERAPY (2017)

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Article Endocrinology & Metabolism

miRNA Signatures of Insulin Resistance in Obesity

Angela Jones et al.

OBESITY (2017)

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Article Endocrinology & Metabolism

Immunoaffinity based methods are superior to kits for purification of prostate derived extracellular vesicles from plasma samples

Sabine I. Brett et al.

PROSTATE (2017)

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Article Oncology

Urinary exosomes reveal protein signatures in hypertensive patients with albuminuria

Laura Gonzalez-Calero et al.

ONCOTARGET (2017)

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Review Oncology

Emerging role of exosome-mediated intercellular communication in vascular remodeling

Sheng-An Su et al.

ONCOTARGET (2017)

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Review Physiology

Exosomes: A Rising Star in Falling Hearts

Jun-Yan Xu et al.

FRONTIERS IN PHYSIOLOGY (2017)

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Article Multidisciplinary Sciences

A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents

Inas Helwa et al.

PLOS ONE (2017)

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Article Biochemistry & Molecular Biology

Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity

Wei Ying et al.

CELL (2017)

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Review Cardiac & Cardiovascular Systems

Extracellular Vesicles in Metabolic Syndrome

M. Carmen Martinez et al.

CIRCULATION RESEARCH (2017)

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Article Urology & Nephrology

Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion

Ying Qi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

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Article Oncology

MicroRNAs modulating angiogenesis: miR-129-1 and miR-133 act as angio-miR in HUVECs

Mina Soufi-Zomorrod et al.

TUMOR BIOLOGY (2016)

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Review Cardiac & Cardiovascular Systems

Tiny Shuttles for Information Transfer: Exosomes in Cardiac Health and Disease

Raj Kishore et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2016)

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Article Multidisciplinary Sciences

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Kateena Addae Konadu et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2016)

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Article Multidisciplinary Sciences

Urinary Exosomal miRNA Signature in Type II Diabetic Nephropathy Patients

Denis Delic et al.

PLOS ONE (2016)

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Article Cell Biology

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

Reka A. Haraszti et al.

JOURNAL OF EXTRACELLULAR VESICLES (2016)

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Article Chemistry, Analytical

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers

Yueting Wu et al.

ANALYST (2015)

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Article Medicine, Research & Experimental

Effects of miRNA-455 on cardiac hypertrophy induced by pressure overload

Chuntao Wu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)

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Meeting Abstract Cardiac & Cardiovascular Systems

MicroRNA Expression Pattern in Patients with Ventricular Tachycardia and End-Stage Heart Failure

T. Calway et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2015)

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Article Cardiac & Cardiovascular Systems

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

Jose M. Vicencio et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

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Article Biochemical Research Methods

Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches

Natasa Zarovni et al.

METHODS (2015)

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Article Cardiac & Cardiovascular Systems

miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8

Mengwen Yan et al.

CARDIOVASCULAR RESEARCH (2015)

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Article Cell Biology

Optimized exosome isolation protocol for cell culture supernatant and human plasma

Richard J. Lobb et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Article Peripheral Vascular Disease

Increased Mean Platelet Volume in Hypertrophic Cardiomyopathy

Atilla Icli et al.

ANGIOLOGY (2014)

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Editorial Material Medicine, Research & Experimental

Stargazing microRNA maps a new miR-21 star for cardiac hypertrophy

Ciro Indolfi et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Article Medicine, Research & Experimental

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

Claudia Bang et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Review Cardiac & Cardiovascular Systems

Fibroblast-mediated pathways in cardiac hypertrophy

Katsuhito Fujiu et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)

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Article Surgery

Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease

Emily S. Koeck et al.

JOURNAL OF SURGICAL RESEARCH (2014)

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Article Biotechnology & Applied Microbiology

miR-29b as a Therapeutic Agent for Angiotensin II-induced Cardiac Fibrosis by Targeting TGF-β/Smad3 signaling

Yang Zhang et al.

MOLECULAR THERAPY (2014)

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Review Cardiac & Cardiovascular Systems

Epidemiological studies of CHD and the evolution of preventive cardiology

Nathan D. Wong

NATURE REVIEWS CARDIOLOGY (2014)

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Review Biochemistry & Molecular Biology

Exosomes as Intercellular Signaling Organelles Involved in Health and Disease: Basic Science and Clinical Applications

Chiara Corrado et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

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Meeting Abstract Cardiac & Cardiovascular Systems

PROTEOMIC CHARACTERIZATION OF THE CARDIAC FIBROBLAST EXOSOME

J. Cosme et al.

CANADIAN JOURNAL OF CARDIOLOGY (2012)

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Article Biochemical Research Methods

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

Bow J. Tauro et al.

METHODS (2012)

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Article Multidisciplinary Sciences

miR-1 Exacerbates Cardiac Ischemia-Reperfusion Injury in Mouse Models

Zhenwei Pan et al.

PLOS ONE (2012)

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Article Cell Biology

Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes

Olivier G. de Jong et al.

JOURNAL OF EXTRACELLULAR VESICLES (2012)

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Article Medicine, General & Internal

Circulating MicroRNAs are Promising Novel Biomarkers of Acute Myocardial Infarction

Rongrong Wang et al.

INTERNAL MEDICINE (2011)

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Review Chemistry, Applied

Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges

Francois Berthiaume et al.

ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 2 (2011)

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Article Cardiac & Cardiovascular Systems

MicroRNA-328 Contributes to Adverse Electrical Remodeling in Atrial Fibrillation

Yanjie Lu et al.

CIRCULATION (2010)

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Article Cell & Tissue Engineering

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

Ruenn Chai Lai et al.

STEM CELL RESEARCH (2010)

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Article Endocrinology & Metabolism

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

Zhong-bin Deng et al.

DIABETES (2009)

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Article Multidisciplinary Sciences

Mechanisms linking obesity to insulin resistance and type 2 diabetes

Steven E. Kahn et al.

NATURE (2006)

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Potential Applications and Functional Roles of Exosomes in Cardiometabolic Disease

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