4.7 Article

Oromucosal Alginate Films with Zein Nanoparticles as a Novel Delivery System for Digoxin

期刊

PHARMACEUTICS
卷 13, 期 12, 页码 -

出版社

MDPI
DOI: 10.3390/pharmaceutics13122030

关键词

oromucosal films; sodium alginate; nanoparticle drug carriers; digoxin; zein; heart failure

资金

  1. Portuguese Foundation for Science and Technology/MCTES [UIDB/00709/2020, UIDP/00709/2020]
  2. project APIMedOlder - FEDER, through COMPETE2020-Programa Operacional Competitividade e Internacionalizacao [PTDC/MEDFAR/31598/2017, POCI-01-0145FEDER-031598]
  3. project ZAPGO - FEDER, through COMPETE2020-Programa Operacional Competitividade e Internacionalizacao [POCI-01-0145FEDER-031598, PTDC/NAN-MAT/28989/2017]
  4. national funds (OE), through the Portuguese Foundation for Science and Technology (FCT/MCTES)
  5. European Union/ERDF, ESF, European Regional Development Fund ERDF under the Interreg V A SpainPortugal (POCTEP) 2014-2020 program [0633_BIOIMPACE_4_A]
  6. Fundação para a Ciência e a Tecnologia [PTDC/NAN-MAT/28989/2017] Funding Source: FCT

向作者/读者索取更多资源

The study demonstrated the potential of sodium alginate films with zein nanoparticles loaded with digoxin for buccal drug delivery, aiming to reduce dosing frequency and facilitate quick onset of action. The innovative formulation showed promising properties for drug delivery application and may offer a safer alternative for digoxin administration compared to existing dosage forms on the market.
Digoxin is a hydrophobic drug used for the treatment of heart failure that possesses a narrow therapeutic index, which raises safety concerns for toxicity. This is of utmost relevance in specific populations, such as the elderly. This study aimed to demonstrate the potential of the sodium alginate films as buccal drug delivery system containing zein nanoparticles incorporated with digoxin to reduce the number of doses, facilitating the administration with a quick onset of action. The film was prepared using the solvent casting method, whereas nanoparticles by the nanoprecipitation method. The nanoparticles incorporated with digoxin (0.25 mg/mL) exhibited a mean size of 87.20 +/- 0.88 nm, a polydispersity index of 0.23 +/- 0.00, and a zeta potential of 21.23 +/- 0.07 mV. Digoxin was successfully encapsulated into zein nanoparticles with an encapsulation efficiency of 91% (+/- 0.00). Films with/without glycerol and with different concentrations of ethanol were produced. The sodium alginate (SA) films with 10% ethanol demonstrated good performance for swelling (maximum of 1474%) and mechanical properties, with a mean tensile strength of 0.40 +/- 0.04 MPa and an elongation at break of 27.85% (+/- 0.58), compatible with drug delivery application into the buccal mucosa. The current study suggests that SA films with digoxin-loaded zein nanoparticles can be an effective alternative to the dosage forms available on the market for digoxin administration.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据