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Immunotherapy for Triple-Negative Breast Cancer

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VISTA Expression on Immune Cells Correlates With Favorable Prognosis in Patients With Triple-Negative Breast Cancer

Xi Cao et al.

Summary: The study evaluated the expression of V-domain Ig suppressor of T-cell activation (VISTA) in triple-negative breast cancer patients and found that VISTA-positive immune cells were associated with better prognosis. It suggested that VISTA could be a potential therapeutic target for TNBC.

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Kai Tang et al.

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Targeting Triple-Negative Breast Cancer with Combination Therapy of EGFR CAR T Cells and CDK7 Inhibition

Lin Xia et al.

Summary: The study revealed that immunosuppressive genes induced by EGFR CAR T cells were sensitive to a CDK7 inhibitor THZ1, which can overcome resistance in TNBC tumors. Combination therapy with THZ1 and EGFR CAR T cells suppressed immune resistance, tumor growth, and metastasis in TNBC tumor models. This suggests that transcriptional modulation using epigenetic inhibitors could offer a potential avenue for treating TNBC in the clinic.

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Zheying Zhang et al.

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Synergistic Effect of Photothermally Targeted NIR-Responsive Nanomedicine-Induced Immunogenic Cell Death for Effective Triple Negative Breast Cancer Therapy

Vellingiri Yasothamani et al.

Summary: TNBC patients currently lack approved targeted therapy, leading to high mortality rates. Developing a new nanotherapeutic approach of combinational therapy, such as HA-PANi/R837 nanoparticles, shows promise in improving treatment outcomes.

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Asynchronous blockade of PD-L1 and CD155 by polymeric nanoparticles inhibits triple-negative breast cancer progression and metastasis

Chuanrong Chen et al.

Summary: PD-L1/PD-1 blockade therapy offers durable responses to triple-negative breast cancer (TNBC) with a low response rate. The coexpression of PD-L1 and CD155 on TNBC cells was verified and the use of P/PEALsiCD155 nanoparticles showed promising results in enhancing immune surveillance and preventing immune escape of TNBC tumors. This combination therapy also induced immunogenic cell death (ICD) and effectively inhibited TNBC progression and metastasis with superior safety in a preclinical model.

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Cancer Immunotherapies: From Efficacy to Resistance Mechanisms - Not Only Checkpoint Matters

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