期刊
PHARMACEUTICS
卷 13, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13101647
关键词
carbohydrates; glycosides; antibacterial; antibiofilm; MRSA; biocompatible; E. coli
资金
- Europaischer Fonds fur regionale Entwicklung (EFRE) in the program Interreg VOberrhein [5115/3.17]
- project CoHMed MS-Tox Test (BMBF) [FKZ: 13FH5E01IA]
- CoHMed-project FunktioMed (BMBF) [FKZ: 13FH5I02IA]
Improving medical implants with functional polymer coatings is an effective way to enhance medical care, especially in wound healing where antibacterial and biofilm-preventing properties are crucial. Specific polymers synthesized in this study showed a reduction in biofilm formation and antibacterial growth without cytotoxic effects on fibroblasts.
Improving medical implants with functional polymer coatings is an effective way to further improve the level of medical care. Antibacterial and biofilm-preventing properties are particularly desirable in the area of wound healing, since there is a generally high risk of infection, often with a chronic course in the case of biofilm formation. To prevent this we here report a polymeric design of polymer-bound N-acetyl-glucosamine-oligoethylene glycol residues that mimic a cationic, antibacterial, and biocompatible chitosan surface. The combination of easy to use, crosslinkable, thin, potentially 3D-printable polymethacrylate layering with antibacterial and biocompatible functional components will be particularly advantageous in the medical field to support a wide range of implants as well as wound dressings. Different polymers containing a N-acetylglucosamine-methacryloyl residue with oligoethylene glycol linkers and a methacryloyl benzophenone crosslinker were synthesized by free radical polymerization. The functional monomers and corresponding polymers were characterized by H-1, C-13 NMR, and infrared (IR) spectroscopy. The polymers showed no cytotoxic or antiadhesive effects on fibroblasts as demonstrated by extract and direct contact cell culture methods. Biofilm formation was reduced by up to 70% and antibacterial growth by 1.2 log, particularly for the 5% GlcNAc-4EG polymer, as observed for Escherichia coli and Staphylococcus aureus as clinically relevant Gram-negative and Gram-positive model pathogens.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据